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科技导报 |专题论文 2014 , 32 (26) : 27 -36
肿瘤生物免疫治疗研究进展
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吴艳红, 王慧茹, 邓振领, 葛科立, 张叔人
作者信息
    中国医学科学院北京协和医学院肿瘤医院肿瘤研究所免疫室, 北京 100021
通讯作者:
张叔人,研究员,研究方向为肿瘤免疫与生物治疗,电子信箱:zhangsr@cicams.ac.cn
作者简介:
吴艳红,博士研究生,研究方向为肿瘤免疫与生物治疗,电子信箱:wuyanhong849@126.com
Progress in Cancer Bio-immunotherapy
  • WU Yanhong, WANG Huiru, DENG Zhenling, GE Keli, ZHANG Shuren
  • Affiliations
      Department of Immunology, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China
      Corresponding Author:
      10.3981/j.issn.1000-7857.2014.26.003
    出版时间: 2014-09-18 doi: 10.3981/j.issn.1000-7857.2014.26.003
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    肿瘤免疫编辑理论的提出阐述了免疫系统在肿瘤发生发展中不可忽视的作用。靶向肿瘤免疫负调控的单克隆抗体在临床的成功应用,更确定了调控免疫系统对有效治疗肿瘤的重要性。未来大有发展潜力的联合免疫治疗手段主要有抗体、细胞因子、肿瘤疫苗、过继免疫细胞治疗和溶瘤病毒等。免疫治疗联合传统的肿瘤治疗包括手术、放疗和化疗,是今后提高肿瘤治疗效果的重要研究和应用方向。本文主要综述抗体治疗、肿瘤疫苗治疗、细胞过继免疫治疗、溶瘤病毒治疗的研究进展,提出相关研究中存在的问题,并对其进行展望。
    肿瘤免疫治疗  /  抗体  /  肿瘤疫苗  /  免疫细胞过继治疗  /  溶瘤病毒
    The cancer immunoediting theory dipicts the significance of immune system in cancer development and progression. The success of antibodies targeting the suppressive immune component has emphasized the importance and effectiveness of immunotherapy in cancer treatment. Combined with surgery, radiotherapy and chemotherapy, immunotherapy including antibody therapy, cytokine, cancer vaccine, adoptive immune cell transfer and oncolytic virus is a potential and promising treatment for cancer. This review will mainly introduce the progress in antibody therapy, cancer vaccine, adoptive cellular immunotherapy and oncolytic virus, as well as point out the problems and future development in cancer bio-immunotherapy.
    cancer immunotherapy  /  antibody  /  cancer vaccine  /  adoptive immune cell transfer  /  oncolytic virus
    吴艳红, 王慧茹, 邓振领, 葛科立, 张叔人. 肿瘤生物免疫治疗研究进展. 科技导报, 2014 , 32 (26) : 27 -36 . DOI: 10.3981/j.issn.1000-7857.2014.26.003
    WU Yanhong, WANG Huiru, DENG Zhenling, GE Keli, ZHANG Shuren. Progress in Cancer Bio-immunotherapy[J]. Science & Technology Review, 2014 , 32 (26) : 27 -36 . DOI: 10.3981/j.issn.1000-7857.2014.26.003

      国家重点基础研究发展计划(973计划)项目(2012CB917104)

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    doi: 10.3981/j.issn.1000-7857.2014.26.003
    • 接收时间:2014-08-12
    • 首发时间:2014-09-26
    • 出版时间:2014-09-18
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    • 收稿日期:2014-08-12
    • 修回日期:2014-08-15
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    通讯作者:

    张叔人,研究员,研究方向为肿瘤免疫与生物治疗,电子信箱:zhangsr@cicams.ac.cn
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    Family
    属数
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    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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