Article(id=1242132139530072411, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242132120861220912, articleNumber=null, orderNo=12, doi=10.3981/j.issn.1000-7857.2014.17.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1368979200000, receivedDateStr=2013-05-20, revisedDate=1395158400000, revisedDateStr=2014-03-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1403241865217, onlineDateStr=2014-06-20, pubDate=1403020800000, pubDateStr=2014-06-18, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1403241865217, onlineIssueDateStr=2014-06-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076979759, creator=sys-migrate, updateTime=1774076979759, updator=sys-migrate, issue=Issue{id=1242132120861220912, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='17', pageStart='1', pageEnd='95', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076975308, creator=sys-migrate, updateTime=1774076975308, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=64, endPage=70, ext={EN=ArticleExt(id=1242132142952620191, articleId=1242132139530072411, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Prethrombotic Seate in Bronchial Asthmatic Patients with Abnormal Savda, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=This paper discusses the changes of CD41, CD62P, ET-1, t-PA, PAI-1, FIB, APTT, PT, and TT in asthma patients with abnormal Savda. Totally 76 asthmatic patients were syndrome typed according to the body fluid theory of Uygur medicine. Among them, there were 30 asthmatic patients with abnormal Savda and 46 asthmatic patients without abnormal Savda. A comparison study was performed with 89 normal individuals (as the healthy control group). The expression of CD62P on platelets, the level of plasma tissue plasminogen activator (t-PA) and its inhibiter (PAI-1), the level of endothelin-1 (ET-1), activated partial thromboplastin time (APTT), fibrinogen (FIB), prothrombin time (PT) and thrombin time (TT) were tested by using flow cytometer, ELASA method, radioimmunoassay method and auto coagulometer. Finally, we found the followings. Compared to the normal control group, there was no significance between the expressions of the asthma with abnormal Savda group and the asthma without abnormal Savda group (P> 0.05); For the expression of CD62P in all the three groups (P<0.05), the expression of CD62P in the asthma with abnormal Savda group was significantly higher than that of the asthma without abnormal Savda group (P<0.05); The level of serum ET-1 was significantly higher in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of ET-1 was significantly higher in the asthma with abnormal Savda group than those of the asthma without abnormal Savda group and the normal control group (P<0.01); The level of plasma t-PA was significantly lower in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of serum PAI-1 was significantly higher in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of plasma FIB was significantly higher in the asthma with abnormal Savda and asthma without abnormal Savda groups (P<0.05), the level of plasma FIB was significantly higher in the asthma with abnormal Savda group than those of the asthma without abnormal Savda group and the normal control group; The level of APTT and PT were significantly shortened in the asthma with abnormal Savda and asthma without abnormal Savda groups (P<0.05). There was no significance on TT between these three groups., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=vJGhxRxUjnB0/A9e/s4Bog==, pdfFileSize=949865, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. Department of Respiratory Disease, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China;
2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China, fund=null, authors=TUERXUN Kelibiena¹, SIMAYI Mihereguli¹, WUFUE Dilinuer¹, AIZEZI Renaguli², UPUR Halmurat², authorsList=TUERXUN Kelibiena, SIMAYI Mihereguli, WUFUE Dilinuer, AIZEZI Renaguli, UPUR Halmurat), CN=ArticleExt(id=1242132142151508118, articleId=1242132139530072411, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=异常黑胆质性哮喘血栓前状态的变化特点, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为探讨新疆维吾尔族异常黑胆质型哮喘患者血栓前状态的变化特点，对76 例哮喘患者按维医体液论进行辨证分型（其中异常黑胆质型哮喘组30 例，非异常黑胆质型哮喘组46 例），并与健康对照组89 名进行对照，检测血小板膜表面糖蛋白CD41 和CD62P、内皮素（ET-1）、组织型纤溶酶原激活物（t-PA）、组织型纤溶酶原激活物抑制剂-1（PAI-1）和凝血4 项指标，即血浆纤维蛋白原（FIB）水平、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）。研究发现，与正常对照组相比，异常黑胆质性哮喘组和非异常黑胆质性哮喘组CD62P、ET-1、PAI-1 水平均升高，差异有统计学意义（P<0.05），且异常黑胆质性哮喘组CD62P、ET-1、PAI-1 水平高于非异常黑胆质性哮喘组，差异有统计学意义（P<0.05）。与正常对照组相比，异常黑胆质性哮喘组和非异常黑胆质性哮喘组t-PA 含量均降低，差异有统计学意义（P<0.05），且以异常黑胆质性哮喘组下降较明显，差异有统计学意义（P<0.05）。与正常对照组相比，异常黑胆质性哮喘组和非异常黑胆质性哮喘组FIB 含量明显升高，差异有统计学意义（P<0.01），且异常黑胆质性哮喘组FIB 含量高于非异常黑胆质性哮喘组，差异有统计学意义（P<0.05）。APTT、PT 时间较正常对照组偏短，差异有统计学意义（P<0.05），APTT、PT 时间在异常黑胆质性哮喘组最短，其次为非异常黑胆质性哮喘组。研究表明，异常黑胆质性哮喘患者的血管内皮细胞、血小板、凝血和纤溶功能都发生紊乱，提示异常黑蛋质性哮喘处于血栓前状态，且这种状态较非异常黑胆质性哮喘更为突出。, correspAuthors=null, authorNote=克丽别娜·吐尔逊，副教授，研究方向为呼吸系统疾病，电子信箱：kelbinur@yeah.net, correspAuthorsNote=哈木拉提·吾甫尔，教授，研究方向为新疆重大疾病的维吾尔医干预，电子信箱：halmurat@263.net, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Z2h4NrxTWObwB0QmUpYyhg==, pdfFileSize=949865, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 新疆医科大学第一附属医院呼吸科, 乌鲁木齐 830011;
2. 新疆医科大学维吾尔医学院, 乌鲁木齐 830011, fund=国家重点基础研究发展计划（973计划）项目（2011CB512004）；长江学者和创新团队发展计划项目（IRT0977）, authors=克丽别娜·吐尔逊¹, 米合热古力·司马义¹, 迪丽努尔·乌甫尔¹, 热娜古丽·艾则孜², 哈木拉提·吾甫尔², authorsList=克丽别娜·吐尔逊, 米合热古力·司马义, 迪丽努尔·乌甫尔, 热娜古丽·艾则孜, 哈木拉提·吾甫尔)}, authors=null, keywords=[Keyword(id=1242132141824352404, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132139530072411, language=CN, orderNo=1, keyword=异常黑胆质型), Keyword(id=1242132141916627092, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132139530072411, language=CN, orderNo=1, keyword=支气管哮喘), Keyword(id=1242132141996318869, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132139530072411, language=CN, orderNo=1, keyword=血栓前状态), Keyword(id=1242132142667411815, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132139530072411, language=EN, orderNo=1, keyword=abnormal Savda), Keyword(id=1242132142747103592, tenantId=1146029695717560320, 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