Article(id=1242131943140176746, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242131927474446936, articleNumber=null, orderNo=12, doi=10.3981/j.issn.1000-7857.2014.13.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1381334400000, receivedDateStr=2013-10-10, revisedDate=1394812800000, revisedDateStr=2014-03-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1400464338377, onlineDateStr=2014-05-19, pubDate=1399478400000, pubDateStr=2014-05-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1400464338377, onlineIssueDateStr=2014-05-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076932935, creator=sys-migrate, updateTime=1774076932935, updator=sys-migrate, issue=Issue{id=1242131927474446936, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='13', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076929202, creator=sys-migrate, updateTime=1774076929202, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=58, endPage=63, ext={EN=ArticleExt(id=1242131946680165008, articleId=1242131943140176746, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Metabonomics Studies on Plasma and Urine of Patients with Breast Cancer Using NMR Spectroscopy, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=Metabonomics studies on plasma and urine of patients with breast cancer using NMR spectroscopy are to establish metabolic markers correlated with breast cancer to guide clinic diagnosis and provide the new ideas and methods. In this study, a total of 45 patients with breast cancer were enrolled and 50 healthy volunteers as controls. Meanwhile, blood and urine samples from the subjects were collected by the researchers for testing. For each sample, the 1H nuclear magnetic resonance (NMR) based metabonomic analysis was performed, the subsection integral of the free attenuation signal was computed, and the obtained data were analyzed by the orthogonal partial least-squares discriminant analysis (OPLS-DA). The results of the study show that compared with the healthy people, leucine, valine, phenylalanine, tyrosine, alanine, histidine, and glycine are significantly decreased (P<0.05); lipid (LDL), beta glucose，lactic acid, choline, inositol and creatine are significantly reduced (P<0.05); glycoprotein, malonic acid, acetoacetic acid, beta hydroxybutyric acid, and acetone are increased significantly (P<0.05) in the plasma of patients with breast cancer. Moreover, isoleucine, valine, glutamic acid, histidine, dimethylamine, hippuric acid, betaine, taurine, succinic acid, citric acid,creatine, and creatinine are decreased (P<0.05) and Lactic acid increased (P<0.05) in urine of patients with breast cancer. Through this study, metabolic markers correlated with breast cancer using changes of metabonomics in plasma and urine have been established., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=eOyEXRmsG9C0GkXzF271aA==, pdfFileSize=1741868, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410013, China;
2. Department of Oncology, the Fourth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China;
3. School of Pharmaceutical Sciences, Xinjiang Medical University, Urumqi 830011, China, fund=null, authors=CHEN Yin^1,2, ZHONG Meizuo¹, UPUR Halmurat³, MAMTIMIN Batur³, DENG Wanli², ZHANG Hongliang², WANG Rui², authorsList=CHEN Yin, ZHONG Meizuo, UPUR Halmurat, MAMTIMIN Batur, DENG Wanli, ZHANG Hongliang, WANG Rui), CN=ArticleExt(id=1242131945753228150, articleId=1242131943140176746, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=乳腺癌患者血浆和尿液的1H-NMR代谢组学, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为探讨乳腺癌患者血浆、尿液代谢组学变化，建立早期诊断的代谢标志物体系。选取乳腺癌患者45例，健康对照30例，获得血浆1H-NMR谱图，对所得自由衰减信号进行分段积分、数据归一化后用正交偏最小二乘法判别分析（OPLS-DA）进行模式识别。与健康人群相比，乳腺癌患者血浆中多种氨基酸含量下降，包括亮氨酸、缬氨酸、苯丙氨酸、酪氨酸、丙氨酸、组氨酸、甘氨酸、脂类（LDL）、β-葡萄糖、乳酸、胆碱、肉碱、肌醇显著减少，差异具有统计学意义（P<0.05）；血浆糖蛋白、丙二酸、乙酰乙酸、β-羟丁酸、丙酮显著增多，差异具有统计学意义（P<0.05）。与健康人相比，乳腺癌患者尿液中异亮氨酸、缬氨酸、谷氨酸、组氨酸、二甲胺、马尿酸、甜菜碱、牛磺酸、琥珀酸、柠檬酸、肌酸、肌酸酐减少，差异具有统计学意义（P<0.05）；乳酸增多，差异具有统计学意义（P<0.05）。通过乳腺癌患者的代谢组学的变化，建立可以用于乳腺癌早期诊断的血浆、尿液代谢标志物体系。, correspAuthors=null, authorNote=陈音，副主任医师，研究方向为肿瘤临床治疗，电子信箱：chenyin713@163.com, correspAuthorsNote=哈木拉提·吾甫尔（通信作者），教授，研究方向为中维西医干预，电子信箱：halmurat@126.com, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=yd9cByFavJRRcNUjqNvp3Q==, pdfFileSize=1741868, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 中南大学湘雅医院肿瘤科, 长沙 410013;
2. 新疆医科大学第四附属医院肿瘤科, 乌鲁木齐 830011;
3. 新疆医科大学药学院, 乌鲁木齐 830011, fund=国家重点基础研究发展计划（973计划）前期研究专项（2011CB512004）, authors=陈音^1,2, 钟美佐¹, 哈木拉提·吾甫尔³, 巴吐尔·买买提明³, 邓皖利², 张洪亮², 王锐², authorsList=陈音, 钟美佐, 哈木拉提·吾甫尔, 巴吐尔·买买提明, 邓皖利, 张洪亮, 王锐)}, authors=null, keywords=[Keyword(id=1242131945367352178, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242131943140176746, language=CN, orderNo=1, keyword=乳腺癌), Keyword(id=1242131945468015475, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242131943140176746, language=CN, orderNo=1, keyword=代谢组学), Keyword(id=1242131945568678771, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242131943140176746, language=CN, orderNo=1, keyword=代谢标志物体系), Keyword(id=1242131946382373753, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242131943140176746, language=EN, orderNo=1, keyword=breast cancer), Keyword(id=1242131946462065530, tenantId=1146029695717560320, journalId=1146031591421210625, 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