Article(id=1242130077257896765, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242130071817880438, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2013.09.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1357315200000, receivedDateStr=2013-01-05, revisedDate=1359993600000, revisedDateStr=2013-02-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1364400000000, onlineDateStr=2013-03-28, pubDate=1364400000000, pubDateStr=2013-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1364400000000, onlineIssueDateStr=2013-03-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076488074, creator=sys-migrate, updateTime=1774076488074, updator=sys-migrate, issue=Issue{id=1242130071817880438, tenantId=1146029695717560320, journalId=1146031591421210625, year='2013', volume='31', issue='9', pageStart='3', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1364400000000', pubDateStr='2013-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076486779, creator='sys-migrate', updateTime=1774076486779, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=23, endPage=26, ext={EN=ArticleExt(id=1242130081699664716, articleId=1242130077257896765, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Functionalization of Multi-walled Carbon Nanotubes for Sustained-releasing Ofloxacin, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=As the third generation of synthetic flouroquinolone antibacterials, the ofloxacin is a potent antifungal agent with a broad antifungal spectrum, a strong antibacterial activity, the ability of completely oral absorption,a wide distribution in tissue and a high bioavailability. By using the nitric acid to treat multi-walled carbon nanotubes (MWNTs) under the microwave irradiation, the carboxyl groups were introduced onto the MWNTs and the oxidized MWNTs (MWNTs-COOH) were prepared. Catalized by the p-toluenesulfonic acid, the poly(ethylene glycol) modified MWNTs (PEG-g-MWNTs) with good dispersivity were synthesized. The PEG-g-MWNTs composites were used as the drug delivery for drug loading/releasing of the ofloxacin. It is indicated that the PEG-g-MWNTs has a great load rate (92.8%) for the ofloxacin, which can be sustained, controlled and released in the phosphate buffer solution (pH=7.4) in 24h., authors=LI Sanqing¹, LIU Yaochi², YU Jingang², authorsList=LI Sanqing;LIU Yaochi;YU Jingang, authorCompany=1. Infectious Diseases Department, the PLA 425 Hospital, Sanya 572000, Hainan Province, China;2. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=o1OfwYtB7yuw9gxSJTNvZg==, pdfFileSize=1282275, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242130080512672673, articleId=1242130077257896765, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=多壁碳纳米管——聚乙二醇复合材料缓释氧氟沙星, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=作为第3代氟诺酮类合成抗菌药,氧氟沙星的抗菌谱广、抗菌活性强、口服吸收完全、体内分布广、生物利用度高.但氧氟沙星有效抑菌浓度低,对多数致病菌的MIC₉₀在1μg·mL^-1内,因此制备更为安全有效的氧氟沙星缓释制剂十分必要.本文采用微波辅助硝酸氧化法修饰了多壁碳纳米管引入羧基,制备了氧化多壁碳纳米管.在对甲苯磺酸催化下,以聚乙二醇修饰了氧化多壁碳纳米管,制备了分散性能较好的多壁碳纳米管-聚乙二醇复合材料.以多壁碳纳米管-聚乙二醇复合材料为药物载体、氧氟沙星为模型药物,考查了多壁碳纳米管-聚乙二醇复合材料的载药释药性能.研究结果表明：多壁碳纳米管-聚乙二醇复合材料具有较大的载药率,达92.8%;在磷酸缓冲溶液(pH=7.4)中,24h内可持续稳定缓慢释放氧氟沙星., authors=李三清¹, 刘耀驰², 于金刚², authorsList=李三清;刘耀驰;于金刚, authorCompany=1. 解放军第425医院感染科,海南三亚 572000;2. 中南大学化学化工学院,长沙 410083, correspAuthors=null, authorNote=null, correspAuthorsNote=于金刚,副教授,研究方向为纳米复合材料制备及其应用领域,电子信箱：yujg_zhoufl@yahoo.com, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=rpxxhUGHbllZoLNn12busA==, pdfFileSize=1282275, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, 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