Article(id=1242129955434332651, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242129934576058746, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2013.h1.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1342108800000, receivedDateStr=2012-07-13, revisedDate=1354291200000, revisedDateStr=2012-12-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1361980800000, onlineDateStr=2013-02-28, pubDate=1361980800000, pubDateStr=2013-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1361980800000, onlineIssueDateStr=2013-02-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076459030, creator=sys-migrate, updateTime=1774076459030, updator=sys-migrate, issue=Issue{id=1242129934576058746, tenantId=1146029695717560320, journalId=1146031591421210625, year='2013', volume='31', issue='5-6', pageStart='3', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1361980800000', pubDateStr='2013-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076454059, creator='sys-migrate', updateTime=1774076454059, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=87, endPage=91, ext={EN=ArticleExt(id=1242129958550704520, articleId=1242129955434332651, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Relationship between Asthma Patients with Abnormal Savda and the Gene Polymorphism of IL-13, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=According to the body fluid theory of Uygur Medicine, 76 cases of asthmatic patients were diagnosed. Among them, there were 30 cases of asthmatic patients with abnormal savda and 46 cases of asthmatic patients with normal savda. The gene polymorphism of IL-13 on loci intron3+1923 and loci +2044 of these patients are tested by using PCR-RFLP, the results are compared with that of the 89 normal individuals in order to explore the relationship between asthmatic Xinjiang Uygur patients with abnormal savda and the gene polymorphism of IL-13. There is significant difference of gene polymorphism of IL-13 on loci intron3+1923 in all three groups(P＜0.01). The distribution rate of genotype TT and TC in asthmatic patients with abnormal savda is significantly higher than that of the asthmatic patients with normal savda and the normal control group(P＜0.01). The distribution rate of genotype TT and TC in asthmatic patients with normal savda is significantly higher than that of the normal control group (P＜0.05). The distribution rate of genotype CC in normal control group is significantly higher than that of the asthmatic patients with abnormal savda(P＜0.01) and higher than that of the asthmatic patients with abnormal savda (P＜0.05). The distribution rate of genotype CC in asthmatic patients with normal savda is significantly higher than that of the asthmatic patients with abnormal savda(P＜0.05). There is significant difference in the distribution rate of allele C and T in all three groups(P＜0.01). The distribution rate of allele T in asthmatic patients with abnormal savda is significantly higher than that of the normal control group(P＜0.01). The distribution rate of allele C in asthmatic patients with abnormal savda is significantly lower than that of the normal control group(P＜0.05). There is insignificant difference in the distribution rate of IL-13 on loci +2044 and the distribution rate of its alleles in all three groups(P＞0.05). In short, Asthma in Xinjiang Uygur Patients with abnormal savda might be related to the gene polymorphism of IL-13 loci intron3+1923, but is not related to the gene polymorphism of IL-13 on loci+ 2044., authors=TUERXUN Kelibiena1, SIMAY Mihereguli1, AIZEZI Renaguli2, WUFUER Dilinuer1, UPUR Halmurat2, authorsList=TUERXUN Kelibiena;SIMAY Mihereguli;AIZEZI Renaguli;WUFUER Dilinuer;UPUR Halmurat, authorCompany=1. Department of ResPiratory, The First Affiliated Hospital, Xinjiang Medical University, Urimqi 830011, China;2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=RrCiJvbepewu5NMh8rDj0Q==, pdfFileSize=1156313, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242129957757981057, articleId=1242129955434332651, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=异常黑胆质性哮喘与白细胞介素-13基因多态性的关系, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=本文通过对76例哮喘患者按维医体液论进行辨证分型,其中异常黑胆质性哮喘组30例、非异常黑胆质性哮喘组46例、正常对照组89例,采用聚合酶联反应——限制性片段长度多态性(PCR-RFLP)技术检测各组IL-13基因intron3+1923位点及IL-13基因+2044位点的多态性,来探讨新疆维吾尔族异常黑胆质性哮喘与白细胞介素-13(IL-13)基因多态性间的关系.结果发现IL-13基因intron3+1923位点多态性,在三组间有显著性差异(P＜0.01),基因型频率异常黑胆质性哮喘组TT、TC基因型分布频率明显高于非异常黑胆质性哮喘组和正常对照组(P＜0.01),非异常黑胆质性哮喘组TT、TC基因型分布频率高于正常对照组(P＜0.05),而正常对照组CC基因型分布频率明显高于异常黑胆质性哮喘组(P＜0.01)和非异常黑胆质性哮喘组(P＜0.05),非异常黑胆质性哮喘组CC基因型分布频率高于异常黑胆质性哮喘组(P＜0.05),等位基因T、C的频率分布在三组人群中有差异(P＜0.01).T等位基因频率分布异常黑胆质性哮喘组高于正常对照组(P＜0.01).C等位基因分布频率异常黑胆质性哮喘组低于正常对照组(P＜0.05).IL-13基因+2044位点基因型频率及等位基因频率分布在各组间比较无差异(P＞0.05).结果表明,新疆维吾尔族异常黑胆质性哮喘可能与IL-13基因intron3+1923位点多态性有关,而与IL-13基因+2044位点无关., authors=克丽别娜·吐尔逊1, 米合热古力·司马义1, 热娜古丽·艾则孜2, 迪丽努尔·乌甫尔1, 哈木拉提·吾甫尔2, authorsList=克丽别娜·吐尔逊;米合热古力·司马义;热娜古丽·艾则孜;迪丽努尔·乌甫尔;哈木拉提·吾甫尔, authorCompany=1. 新疆医科大学第一附属医院呼吸一科,乌鲁木齐 830011;2. 新疆医科大学维吾尔医学院,乌鲁木齐 830011, correspAuthors=null, authorNote=null, correspAuthorsNote=哈木拉提·吾甫尔(通讯作者),教授,研究方向为新疆重大疾病的维吾尔医干预研究,电子信箱：halmurat@263.net, copyrightStatement=null, 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1. Department of ResPiratory, The First Affiliated Hospital, Xinjiang Medical University, Urimqi 830011, China;2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China
According to the body fluid theory of Uygur Medicine, 76 cases of asthmatic patients were diagnosed. Among them, there were 30 cases of asthmatic patients with abnormal savda and 46 cases of asthmatic patients with normal savda. The gene polymorphism of IL-13 on loci intron3+1923 and loci +2044 of these patients are tested by using PCR-RFLP, the results are compared with that of the 89 normal individuals in order to explore the relationship between asthmatic Xinjiang Uygur patients with abnormal savda and the gene polymorphism of IL-13. There is significant difference of gene polymorphism of IL-13 on loci intron3+1923 in all three groups(P＜0.01). The distribution rate of genotype TT and TC in asthmatic patients with abnormal savda is significantly higher than that of the asthmatic patients with normal savda and the normal control group(P＜0.01). The distribution rate of genotype TT and TC in asthmatic patients with normal savda is significantly higher than that of the normal control group (P＜0.05). The distribution rate of genotype CC in normal control group is significantly higher than that of the asthmatic patients with abnormal savda(P＜0.01) and higher than that of the asthmatic patients with abnormal savda (P＜0.05). The distribution rate of genotype CC in asthmatic patients with normal savda is significantly higher than that of the asthmatic patients with abnormal savda(P＜0.05). There is significant difference in the distribution rate of allele C and T in all three groups(P＜0.01). The distribution rate of allele T in asthmatic patients with abnormal savda is significantly higher than that of the normal control group(P＜0.01). The distribution rate of allele C in asthmatic patients with abnormal savda is significantly lower than that of the normal control group(P＜0.05). There is insignificant difference in the distribution rate of IL-13 on loci +2044 and the distribution rate of its alleles in all three groups(P＞0.05). In short, Asthma in Xinjiang Uygur Patients with abnormal savda might be related to the gene polymorphism of IL-13 loci intron3+1923, but is not related to the gene polymorphism of IL-13 on loci+ 2044.
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