科技导报

围绝经期综合征患者舌苔脱落细胞凋亡调控基因与肝郁病理的关系研究

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科技导报 | 研究论文 2011,29(11-10): 24-28

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科技导报 | 研究论文 2011, 29(11-10): 24-28

围绝经期综合征患者舌苔脱落细胞凋亡调控基因与肝郁病理的关系研究

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^{梁文娜 1，李灿东1，高碧珍2，廖凌虹1，张凌媛1，林雪娟1，李红3}

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通讯作者:

梁文娜

Study on the interrelationship of tongue epithelial cell apoptosis regulation of gene and pathological changes of liver depression in perimenopausal syndrome

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出版时间: 2011-04-08 doi: 10.3981/j.issn.1000-7857.2011.10.002

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通过研究围绝经期综合征舌苔脱落细胞调控蛋白与肝郁病理的相关性，为临床诊疗提供实验依据。本研究采用随机数字表法，选取50例健康妇女作为对照组，150例围绝经期综合征患者作为观察组，证素辨证计算肝郁积分，巴氏染色检测舌苔脱落细胞的成熟指数（MI）和成熟价值（MV），流式细胞仪检测舌苔脱落细胞凋亡指数，免疫组化检测舌苔脱落细胞调控蛋白。结果显示，围绝经期综合征肝郁积分明显高于健康妇女；肝郁病理改变，与舌苔脱落细胞MI的中层细胞数量呈正相关，与舌苔脱落细胞MI的表层细胞数量及MV呈负相关；肝郁病理改变，与舌苔脱落细胞凋亡指数、Fas、Bax的阳性率呈正相关，与舌苔脱落细胞中Bcl-2的阳性率呈负相关。提示肝郁病理是围绝经期综合征的核心病机之一，肝郁病理与舌苔脱落细胞的成熟度、凋亡指数及凋亡调控蛋白相关。

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围绝经期综合征 / 肝郁病理 / 脱落细胞 / 凋亡

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The interrelationship between tongue epithelial cell apoptosis regulation of portein and pathological changes of liver depression in perimenopausal syndrome is investigated to provide a solid experimental basis for related clinical diagnosis and treatment. 50 cases of healthy women and 150 cases of perimenopausal syndrome patients were randomly divided into the control group and experimental groups. Liver depression points were evaluated by syndrome element differentiation; Maturation Index (MI) and Maturation Value (MV) of tongue epithelial cells were determined by Papanicolaou staining; the apoptotic rate of tongue epithelial cells was measured by flow cytometric; and the apoptosis regulation of portein was determined by immunohistochemical. The results show that liver depression points of syndrome patients are significantly higher than those of healthy women; pathological changes of liver depression, and the middle cells MI of tongue epithelial cells are positively correlated, and the surface cells MI and MV of tongue epithelial cells are negatively correlated; pathological changes of liver depression, and apoptotic rate, Fas, Bax of tongue epithelial cells are positively correlated, and Bcl-2 of tongue epithelial cells are negatively correlated. It is concluded that the liver depression is one of the cores of pathogenesisa in the perimenopausal syndrome, and the tongue epithelial cells maturity, apoptotic rate and apoptosis related regulation of gene are interrelated.

Key words

perimenopausal syndrome / liver depression / tongue epithelial cell / apoptosis

引用本文

梁文娜;李灿东;高碧珍;廖凌虹;张凌媛;林雪娟;李红. 围绝经期综合征患者舌苔脱落细胞凋亡调控基因与肝郁病理的关系研究. 科技导报, 2011 , 29 (11-10) : 24 -28 . DOI: 10.3981/j.issn.1000-7857.2011.10.002

. Study on the interrelationship of tongue epithelial cell apoptosis regulation of gene and pathological changes of liver depression in perimenopausal syndrome[J]. Science & Technology Review, 2011 , 29 (11-10) : 24 -28 . DOI: 10.3981/j.issn.1000-7857.2011.10.002

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2011年第29卷第11-10期

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doi: 10.3981/j.issn.1000-7857.2011.10.002

接收时间：2010-10-07
首发时间：2011-04-08
出版时间：2011-04-08

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收稿日期：2010-10-07
修回日期：2011-03-16

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梁文娜

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https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2011.10.002

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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