Article(id=1242120318370775302, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242120303908815076, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1271779200000, receivedDateStr=2010-04-21, revisedDate=1279468800000, revisedDateStr=2010-07-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1278950400000, onlineDateStr=2010-07-13, pubDate=1278950400000, pubDateStr=2010-07-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1278950400000, onlineIssueDateStr=2010-07-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774074161376, creator=sys-migrate, updateTime=1774074161376, updator=sys-migrate, issue=Issue{id=1242120303908815076, tenantId=1146029695717560320, journalId=1146031591421210625, year='2010', volume='28', issue='15', pageStart='3', pageEnd='140', issueExtLink='null', onlineDate='null', pubDate='1278950400000', pubDateStr='2010-07-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774074157929, creator='sys-migrate', updateTime=1774074157929, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=21, endPage=25, ext={EN=ArticleExt(id=1242120321306788125, articleId=1242120318370775302, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Dynamic Imaging of Mild Cognitive Impairment with 11C-PIB, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=The early diagnosis and treatment is very important for patients with Alzheimer's Disease (AD), which can be progressed from Mild Cognitive Impairment (MCI). The aims of this study include: (1) to determine the localization and the load of the beta-amyloid protein in the brains of MCI patients in vivo using 11C-PIB PET dynamic imaging; (2) to evaluate the clinical value of 11C-PIB PET imaging in MCI. 21 subjects, which were divided into three groups: 8 patients with MCI, 6 with AD, and 7 as Health Control (HC). All patients underwent sequential emission PET scans of brain after 11C-PIB administration. All 11C-PIB PET images were visually interpreted and analyzed by the Region of Interest (ROI) method. The attenuation-corrected PET images were semi-quantitatively analyzed using Standardized Uptake Value (SUV). Dynamic SUV data and curves were obtained as a function of time from 0 to 55 minutes of post-injection time. The ratio of radioactivity clearance and ratio of SUV of targeted brain regions vs cerebellum at 45min were calculated for statistical analysis. The dynamic images show that 11C-PIB passes cross the blood-brain barrier very rapidly, and clears rapidly in healthy brain. The results of applying the visual and ROI method indicate that AD patients typically show marked retention of 11C-PIB in related cortex where a large amount of amyloid is deposited. In MCI patients, the PET image of some patients are HC-like, and others are AD-like. Therefore, the MCI patients can be divided into 2 groups (HC-like group and AD-like group) for analysis, and the visual interpretations are consistent with the statistical analysis results. There are no significant difference observed in the data between HC-like group and HC group, and between AD-like group and AD group, respectively. It is concluded that 11C-PIB PET imaging can provide reliable quantitative information about beta-amyloid protein in living AD and MCI patients, and 11C-PIB PET imaging is a promising method to evaluate the prognosis of MCI., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2UVado8MA9h0KipEzCNg/w==, pdfFileSize=2450104, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242120320283377943, articleId=1242120318370775302, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=轻度认知功能障碍11C-PIB PET连续动态显像结果分析, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为探讨轻度认知功能障碍（MCI）患者碳-11标记的匹兹堡化合物B（11C-PIB）正电子放射断层摄影术（PET）显像的特点，评价MCI患者11C-PIB PET脑显像的临床价值，严格筛选3组受试者：MCI患者8例，阿尔茨海默病（AD）对照组6例，健康对照（HC）组7例。每位受试者均采用连续动态采集程序采集脑PET图像。通过视觉分析各组受试者的图像，总结成像特点。采用感兴趣区域（ROI）方法划取大脑皮层各叶和皮层下核团，得出各个脑区不同时间点的标准吸收值（SUV），根据SUV绘出时间-放射性曲线。并选取45min时间点的SUV，计算出45min时各脑区与小脑的SUV比值并进行统计分析。结果发现，MCI组中一部分受试者PET图像特点与HC组相似；脑内放射性清除较快，而另外一部分受试者的脑内放射性清除则较慢。将MCI按照显像结果分为AD类似组及HC类似组进行分析后发现，AD类似组与AD组之间的清除率及脑区/小脑比值相比差异无统计学意义，而AD类似组与HC组之间的结果比较类似于AD组与HC组的比较结果。HC类似组与HC组之间的清除率及脑区/小脑比值相比差异无统计学意义，而HC类似组与AD组之间的结果比较则类似于HC组与AD组的比较结果。11C-PIB PET脑显像在不同MCI患者脑内的显像特点不同，因而有可能成为判断MCI预后的一种方法。, authors=^{郭 喆1，姚树林2，张锦明2，尹大一2，田嘉禾2，冯惠茹1，贾建军3，孙彬彬3}, authorsList=郭 喆;姚树林;张锦明;尹大一;田嘉禾;冯惠茹;贾建军;孙彬彬, authorCompany=1. 北京军区总医院核医学科，北京 1007002. 解放军总医院核医学科，北京 1008533. 解放军总医院神经内科，北京 100853, correspAuthors=null, authorNote=null, correspAuthorsNote=郭喆, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, 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