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科技导报
|研究论文
2010
, 28
(06) :
46
-49
5'-核苷酸对小鼠获得性免疫调节作用研究
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赵 明1，杨睿悦1,2，张召锋1，梁 江1，李 琼1，王军波1，李 勇1
作者信息
1. 北京大学医学部公共卫生学院营养与食品卫生学系，北京 1001912. 卫生部北京医院/卫生部北京老年医学研究所；卫生部老年医学重点实验室，北京 100730
通讯作者:
赵明
Effects of 5’-nucleotides on Modulation of Adaptive Immunity of Mice
Affiliations
出版时间: 2010-03-28
文章导航
为了评价5’-核苷酸对小鼠获得性免疫功能的影响，将健康雌性BALB/c小鼠以普通饲料、无核苷酸饲料（NF）及不同剂量5’-核苷酸的饲料（0.0025%，0.01%，0.04%，0.16%）喂养4周后，观察小鼠细胞免疫功能、体液免疫功能、血清免疫球蛋白水平以及脾脏淋巴细胞亚群的改变。结果显示无核苷酸饮食可以显著减弱淋巴细胞增殖能力（OD差值0.06±0.03）和足跖肿胀度（0.12±0.06）mm；CD4+/CD8+（1.90±0.12）显著下降，T调节细胞比例（5.56±0.11）%显著升高；溶血空斑数（1.48±0.21）有减弱趋势。饲料中添加5’-核苷酸后，免疫水平有所回升。当添加到0.04%时，小鼠的各项免疫水平均比NF组有显著提高，达到正常对照组水平。总之，无核苷酸饲料喂养小鼠免疫功能降低。在无核苷酸饲料中添加5’-核苷酸能恢复小鼠免疫功能，当饲料中核苷酸含量为0.04%时小鼠免疫功能恢复到最佳水平。
核苷酸
/
免疫调节
/
免疫球蛋白
/
T细胞亚群
/
小鼠
To study the effects of 5'-nucleotides on modulation of adaptive immunity of mice and to determine the best dosage, female BALB/c mice were administered with common control diet, Nucleotides-Free(NF) diet and NF diet with 0.0025%, 0.01%, 0.04%, 0.16% 5'-nucleotides for 4 weeks. Cellular immune functions, humoral immune functions, the level of immunoglobulin in serum and splenic T cell subpopulations of the spleen tissue by the flow cytometer were examined. The results show that with the NF diet, the capacity of lymphocyte proliferation induced by ConA (0.06±0.03) and DTH response (0.12±0.06)mm are significantly reduced; the ratio of CD4+/CD8+ is decreased (1.90±0.12) while Tr percentage is increased (5.56±0.11). A decrease trend of B lymphocytes antibody response was observed. The NF diet with 5'-nucleotides can prevent these decreases. At the dose of 0.04%, the immunological functions are increased significantly as compared with those of NF group, reaching normal values. The results indicate that the NF diet can impair the immunological function of mice, while the NF diet with 5'-nucleotides can prevent the decrease, and 0.04% is the best dose.
nucleotides
/
immunomodulate
/
immunoglobulin
/
T subset
/
mice
赵 明;杨睿悦;张召锋;梁 江;李 琼;王军波;李 勇.
5'-核苷酸对小鼠获得性免疫调节作用研究.
科技导报,
2010
, 28
(06)
: 46
-49
.
.
Effects of 5’-nucleotides on Modulation of Adaptive Immunity of Mice[J].
Science & Technology Review ,
2010
, 28
(06)
: 46
-49
.
2010年第28卷第06期
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接收时间：2010-01-06
首发时间：2010-03-28
出版时间：2010-03-28
收稿日期：2010-01-06
修回日期：2010-01-29
https://castjournals.cast.org.cn/joweb/kjdb/CN/1242119759144227025
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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