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Except for the normal control group, mice in all other groups were made immune suppression models by using cyclophosphamide(75mg/kg, OD). Abnormal savda munziq granular was orally administered for 14 days, once a day. The mononuclear phagocyte englobement function, the quantity of T cell subpopulation in peripheral blood, NK cyto-active, interleukin-1 and interleukin-2 activity, TNF-α activity, serum hemolysin(CH50), delayed allergy were monitored. Three groups of abnormal savda munziq granular were found to have made remarkable improvement in the mononuclear phagocyte englobement function, the quantity of T cell subpopulation in peripheral blood, serum hemolysin, delayed allergy (P<0.05). The IgM and IgG values were also improved remarkably(P<0.05). In the groups of abnormal savda munziq granular, the NK cyto-active, and TNF-α, activities were remarkably improved for the medium dose and the high dose groups. There was a tendency in abnormal savda munziq granular groups of increasing the activities of IL-1 in lower dose group and those of IL-2 in medium dose group (P<0.05). 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articleAbstract=为研究异黑成熟颗粒对环磷酰胺诱导免疫抑制小鼠的非特异性免疫功能、体液免疫功能、细胞免疫功能的影响,将84只小鼠随机分为6组:正常对照组,环磷酰胺模型组,阳性对照组,异黑成熟颗粒低、中、高剂量组,每组14只。除正常对照组外,其他组小鼠均用75mg/kg环磷酰胺腹腔注射诱导免疫抑制小鼠模型,阳性对照组和异黑成熟颗粒组连续灌胃给药14d,1次/d。测定小鼠单核巨噬细胞吞噬功能、外周血T细胞亚群、NK细胞活性、白介素-1(IL-1)活性、白介素-2(IL-2)活性、肿瘤坏死因子-α(TNF-α)活性、血清溶血素抗体生成(CH50)、迟发型变态反应等。结果表明,异黑成熟颗粒3个剂量组对环磷酰胺诱导的免疫抑制小鼠的单核巨噬细胞吞噬功能、外周血T细胞亚群数量、对2,4-二硝基氯苯(DNCB)诱导的迟发性变态反应、免疫器官重量和IgM、IgG值等均具有明显增强作用(P<0.05);异黑成熟颗粒中、高剂量组明显增强小鼠NK细胞和TNF-α活性(P<0.05);异黑成熟颗粒能提高小鼠IL-1和IL-2的活性(P<0.05)。异黑成熟颗粒对免疫抑制小鼠的免疫功能具有改善作用。, authors=阿不都热依木·玉苏甫1,古孜力努尔·依马木1,努尔江·肉孜1,艾尼娃尔·艾克木2,哈木拉提·吾甫尔1 , authorsList=阿不都热依木·玉苏甫;古孜力努尔·依马木;努尔江·肉孜;艾尼娃尔·艾克木;哈木拉提·吾甫尔, authorCompany=1. 新疆医科大学维吾尔医药系,乌鲁木齐 8300112. 新疆医科大学药学院,乌鲁木齐 830011, correspAuthors=null, authorNote=null, correspAuthorsNote=哈木拉提·吾甫尔, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=CNYgKcCE9tn66MznNYdFWg==, pdfFileSize=2988346, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, 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科技导报
|研究论文
2010
, 28
(03) :
82
-86
异黑成熟颗粒对免疫抑制小鼠免疫功能的调节作用
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阿不都热依木·玉苏甫1,古孜力努尔·依马木1,努尔江·肉孜1,艾尼娃尔·艾克木2,哈木拉提·吾甫尔1
作者信息
1. 新疆医科大学维吾尔医药系,乌鲁木齐 8300112. 新疆医科大学药学院,乌鲁木齐 830011
通讯作者:
哈木拉提·吾甫尔
Effects of Immune Regulation of Abnormal Savda Munziq Granular on Immune Suppressed Mice
Affiliations
出版时间: 2010-02-13
文章导航
为研究异黑成熟颗粒对环磷酰胺诱导免疫抑制小鼠的非特异性免疫功能、体液免疫功能、细胞免疫功能的影响,将84只小鼠随机分为6组:正常对照组,环磷酰胺模型组,阳性对照组,异黑成熟颗粒低、中、高剂量组,每组14只。除正常对照组外,其他组小鼠均用75mg/kg环磷酰胺腹腔注射诱导免疫抑制小鼠模型,阳性对照组和异黑成熟颗粒组连续灌胃给药14d,1次/d。测定小鼠单核巨噬细胞吞噬功能、外周血T细胞亚群、NK细胞活性、白介素-1(IL-1)活性、白介素-2(IL-2)活性、肿瘤坏死因子-α(TNF-α)活性、血清溶血素抗体生成(CH50)、迟发型变态反应等。结果表明,异黑成熟颗粒3个剂量组对环磷酰胺诱导的免疫抑制小鼠的单核巨噬细胞吞噬功能、外周血T细胞亚群数量、对2,4-二硝基氯苯(DNCB)诱导的迟发性变态反应、免疫器官重量和IgM、IgG值等均具有明显增强作用(P<0.05);异黑成熟颗粒中、高剂量组明显增强小鼠NK细胞和TNF-α活性(P<0.05);异黑成熟颗粒能提高小鼠IL-1和IL-2的活性(P<0.05)。异黑成熟颗粒对免疫抑制小鼠的免疫功能具有改善作用。
This paper investigates the effects of abnormal savda munziq granular on nonspecific immunity, humeral immunity, cell immunity functions of cyclophosphamide induced immune suppressed mice. 84 qualified mice were randomly divided into 6 groups with 14 in each group: normal control group, model group, groups of abnormal savda munziq granular for high, medium, low dosages and the control group. Except for the normal control group, mice in all other groups were made immune suppression models by using cyclophosphamide(75mg/kg, OD). Abnormal savda munziq granular was orally administered for 14 days, once a day. The mononuclear phagocyte englobement function, the quantity of T cell subpopulation in peripheral blood, NK cyto-active, interleukin-1 and interleukin-2 activity, TNF-α activity, serum hemolysin(CH50), delayed allergy were monitored. Three groups of abnormal savda munziq granular were found to have made remarkable improvement in the mononuclear phagocyte englobement function, the quantity of T cell subpopulation in peripheral blood, serum hemolysin, delayed allergy (P<0.05). The IgM and IgG values were also improved remarkably(P<0.05). In the groups of abnormal savda munziq granular, the NK cyto-active, and TNF-α, activities were remarkably improved for the medium dose and the high dose groups. There was a tendency in abnormal savda munziq granular groups of increasing the activities of IL-1 in lower dose group and those of IL-2 in medium dose group (P<0.05). Abnormal savda munziq granular could improve the immunological function of immune suppressed mice.
Abnormal Savda Munziq granular
/
immune suppression
/
immune function
阿不都热依木·玉苏甫;古孜力努尔·依马木;努尔江·肉孜;艾尼娃尔·艾克木;哈木拉提·吾甫尔.
异黑成熟颗粒对免疫抑制小鼠免疫功能的调节作用.
科技导报,
2010
, 28
(03)
: 82
-86
.
.
Effects of Immune Regulation of Abnormal Savda Munziq Granular on Immune Suppressed Mice[J].
Science & Technology Review ,
2010
, 28
(03)
: 82
-86
.
2010年第28卷第03期
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接收时间:2009-10-30
首发时间:2010-02-13
出版时间:2010-02-13
收稿日期:2009-10-30
修回日期:2010-01-19
https://castjournals.cast.org.cn/joweb/kjdb/CN/1242119550892835202
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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