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articleAbstract=通过观察PTEN在哈萨克族食管癌癌组织及相应正常组织中的表达，探讨PTEN基因在哈萨克族食管癌发生中的作用。采用RT-PCR方法检测PTEN基因mRNA在36例哈萨克族食管癌及相应正常组织标本中的表达，选取mRNA水平差异组织标本，采用Western-bolt方法检测其蛋白水平的表达情况。结果显示，PTEN基因mRNA在36例癌组织中有30例表达，阳性率为83.33%。其中癌组织表达量高于相应正常组织（T>N）21例，占70%；癌组织表达量等于相应正常组织（T=N）4例，占13.33%；癌组织表达量低于相应正常组织（T<N）5例，占16.67%。PTEN基因mRNA在正常组织中表达仅有9例。癌组织与相应正常组织相比，PTEN基因的表达量明显增高。PTEN蛋白的表达在癌组织与相应正常组织中无明显差异。结果表明，PTEN基因的异常表达主要在转录水平，可能不是哈萨克族食管癌发生发展中的主导基因，其对哈萨克族食管癌发生发展过程中的具体作用有待进一步研究。, authors=郭文佳1,王洪江2,李卉1,庞作良2,陈艳1,刘玲1,李秀梅1,李惠武1, authorsList=郭文佳;王洪江;李卉;庞作良;陈艳;刘玲;李秀梅;李惠武, authorCompany=1. 新疆医科大学基础医学院，乌鲁木齐 8300002. 新疆医科大学附属肿瘤医院，乌鲁木齐 830000, correspAuthors=null, authorNote=null, correspAuthorsNote=李惠武, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=8csNle2n6M4diZfn1HznAA==, pdfFileSize=315197, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, 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科技导报
|研究论文
2010
, 28
(1001) :
48
-50
PTEN基因在哈萨克族食管癌组织中的表达及意义
全屏
郭文佳1,王洪江2,李卉1,庞作良2,陈艳1,刘玲1,李秀梅1,李惠武1
作者信息
1. 新疆医科大学基础医学院，乌鲁木齐 8300002. 新疆医科大学附属肿瘤医院，乌鲁木齐 830000
通讯作者:
李惠武
Affiliations
出版时间: 2010-01-13
文章导航
通过观察PTEN在哈萨克族食管癌癌组织及相应正常组织中的表达，探讨PTEN基因在哈萨克族食管癌发生中的作用。采用RT-PCR方法检测PTEN基因mRNA在36例哈萨克族食管癌及相应正常组织标本中的表达，选取mRNA水平差异组织标本，采用Western-bolt方法检测其蛋白水平的表达情况。结果显示，PTEN基因mRNA在36例癌组织中有30例表达，阳性率为83.33%。其中癌组织表达量高于相应正常组织（T>N）21例，占70%；癌组织表达量等于相应正常组织（T=N）4例，占13.33%；癌组织表达量低于相应正常组织（T<N）5例，占16.67%。PTEN基因mRNA在正常组织中表达仅有9例。癌组织与相应正常组织相比，PTEN基因的表达量明显增高。PTEN蛋白的表达在癌组织与相应正常组织中无明显差异。结果表明，PTEN基因的异常表达主要在转录水平，可能不是哈萨克族食管癌发生发展中的主导基因，其对哈萨克族食管癌发生发展过程中的具体作用有待进一步研究。
哈萨克族食管癌
/
PTEN基因
/
RT-PCR
/
Western-bolt
郭文佳;王洪江;李卉;庞作良;陈艳;刘玲;李秀梅;李惠武.
PTEN基因在哈萨克族食管癌组织中的表达及意义.
科技导报,
2010
, 28
(1001)
: 48
-50
.
2010年第28卷第1001期
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文章信息
- 接收时间：2009-11-09
- 首发时间：2010-01-13
- 出版时间：2010-01-13
- 收稿日期：2009-11-09
- 修回日期：2009-07-27
https://castjournals.cast.org.cn/joweb/kjdb/CN/1242119405950276506
引用本文
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2种不同金属材料的力学参数
科
Family | 属数
Number of
genus | 种数
Number of
species | 占总种数比例
Percentage of
total species (%) | 属
Genus | 种数
Number of
species | 占总种数比例
Percentage of total
species (%) |
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| | | | | 小菇属 Mycena | 11 | 5.26 |
| | | | | 光柄菇属 Pluteus | 5 | 2.39 |
| | | | | 红菇属 Russula | 17 | 8.13 |
| | | | | 栓菌属 Trametes | 5 | 2.39 |
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