Article(id=1242119333946655218, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242119332617060839, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1259769600000, receivedDateStr=2009-12-03, revisedDate=-2209017600000, revisedDateStr=1900-01-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1261929600000, onlineDateStr=2009-12-28, pubDate=1261929600000, pubDateStr=2009-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1261929600000, onlineIssueDateStr=2009-12-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073926671, creator=sys-migrate, updateTime=1774073926671, updator=sys-migrate, issue=Issue{id=1242119332617060839, tenantId=1146029695717560320, journalId=1146031591421210625, year='2009', volume='27', issue='0924', pageStart='1', pageEnd='140', issueExtLink='null', onlineDate='null', pubDate='1261929600000', pubDateStr='2009-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073926355, creator='sys-migrate', updateTime=1774073926355, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=29, endPage=33, ext={EN=ArticleExt(id=1242119337419543252, articleId=1242119333946655218, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Discovery of Telomeres and Telomerase: Brief Introduction of the 2009 Nobel Prize in Physiology or Medicine, columnId=1150494642224591153, journalTitle=Science & Technology Review, columnName=Exclusive, runingTitle=null, highlight=null, articleAbstract=The 2009 Nobel Prize in Physiology or Medicine is awarded to Dr. Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak for their discovery of how chromosomes are protected by telomeres and the enzyme telomerase. Telomere is a specific structure of chromosomal termini composed of a series of DNA repeats, to protect the stability and integrity of chromosome. Depending on an intrinsic RNA template, telomerase synthesizes telomere DNA, and maintains the length of telomere. The discovery of telomere and telomerase has solved a long-standing fundamental problem in biology: how can the end of chromosomes be maintained and spared from erosion during repeated cellular divisions. The discovery has a deep influence on biological and biochemical research, and has provided insights into our understanding of the molecular mechanisms of aging, aging related diseases and cancers., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=SxfAdv389xzuNtdi1l8nKg==, pdfFileSize=470014, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242119335569850883, articleId=1242119333946655218, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=端粒和端粒酶的发现——2009年度诺贝尔生理学或医学奖成果介绍, columnId=1150494644438708440, journalTitle=科技导报, columnName=本刊专稿, runingTitle=null, highlight=null, articleAbstract=2009年度诺贝尔生理学或医学奖在瑞典卡罗林斯卡医学院揭晓，美国加利福尼亚旧金山大学的Elizabeth H. Blackburn、美国巴尔的摩约翰·霍普金斯医学院的Carol W. Greider和美国哈佛医学院的Jack W. Szostak获得该奖，以表彰他们发现了端粒和端粒酶保护染色体的机制。端粒是染色体末端由DNA重复序列组成的一种特殊结构，具有维持染色体结构稳定性的功能，会随染色体复制与细胞分裂而缩短。端粒酶作用于端粒，依靠自身RNA模板合成端粒DNA，维持端粒的长度与结构完整。端粒和端粒酶的发现解释了生物学中长期未解决的染色体末端复制问题，推动了生物学和生物医学相关领域的发展，为研究衰老、与衰老相关的疾病和肿瘤发生发展的分子机制提供了新的思路。, authors=郗鹏, authorsList=郗鹏, authorCompany=北京师范大学生命科学学院， 北京 100875, correspAuthors=null, authorNote=null, correspAuthorsNote=郗鹏, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=MyHW4jY8kPiJgcP3WRruqw==, pdfFileSize=470014, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242119334747767291, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242119333946655218, language=CN, orderNo=1, keyword=端粒), Keyword(id=1242119334827459068, 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