Article(id=1242118893293077235, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242118891057513199, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1251043200000, receivedDateStr=2009-08-24, revisedDate=-2209017600000, revisedDateStr=1900-01-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1126281600000, onlineDateStr=2005-09-10, pubDate=1126281600000, pubDateStr=2005-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1126281600000, onlineIssueDateStr=2005-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073821612, creator=sys-migrate, updateTime=1774073821612, updator=sys-migrate, issue=Issue{id=1242118891057513199, tenantId=1146029695717560320, journalId=1146031591421210625, year='2005', volume='23', issue='0509', pageStart='1', pageEnd='79', issueExtLink='null', onlineDate='null', pubDate='1126281600000', pubDateStr='2005-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073821079, creator='sys-migrate', updateTime=1774073821079, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=23, endPage=25, ext={EN=ArticleExt(id=1242118899144131342, articleId=1242118893293077235, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Role of Human Heart Developmental Candidate Gene hole in MAPK Signaling Pathway, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of eukaryotic cell regulation, and MAPK has a close relationship with cardiovascular development and diseases such as cardiomyotrophy. Overexpression of hole in the COS-7 cells inhibits strongly the transcriptional activities of AP-1 and SRE. Hole functions as a inhibitor probably through its ERK D-domian in N-terminal and proline-rich region in C-terminal. The results suggest that hole might be involved in heart development through MAPK signaling pathway., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Ez3yIf8LIU/PnhPZNVrWzw==, pdfFileSize=297705, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242118897978114822, articleId=1242118893293077235, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=人心脏发育候选基因hole在MAPK信号传导途径中的作用, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=MAPK信号传导途径是存在于真核细胞中的最广泛的一种调节机制,它与心血管的发育、心肌肥大等心脏疾病的发生有着密切的关系。利用荧光素酶的活性分析讨论人hole基因在MAPK信号途径中的作用。实验表明,COS-7细胞中过表达hole蛋白能够强烈抑制MAPK信号途径的2个下游转录因子AP-1和SRE的转录活性。hole的突变体报道基因分析表明,hole基因可能是通过其N′端的ERK结合区和C′端的多聚脯氨酸序列来行使其抑制作用的。研究表明,该基因可能通过参与MAPK信号途径而在心脏发育的过程中起作用。, authors=周军媚¹,吴秀山², authorsList=周军媚;吴秀山, authorCompany=1. 南华大学生命科学与技术学院生物教研室 湖南衡阳2. 湖南师范大学生命科学学院心脏发育研究中心 长沙, correspAuthors=null, authorNote=null, correspAuthorsNote=吴秀山, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=w+E3+w5WldERtdzpehEfJA==, pdfFileSize=297705, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=[Author(id=1299702773621215453, tenantId=1146029695717560320, journalId=null, articleId=1242118893293077235, orderNo=null, firstName=null, 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