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There are around one-third of the world's population is latently infected. In recent years, the tuberculosis control situation is even grimmer along with the multi-drug resistant MTB and HIV epidemic. MTB is a highly adapted human pathogen that has evolved with multiple strategies in its attempt to avoid an efficient host immune response. Apoptosis is an ancient immune defense response to intracellular pathogens in both plant and animal kingdoms. This paper reviews the current progresses in the field of interaction between mycobacteria and host cells regarding the induction of host cell death by apoptosis. It is believed that MTB can modulate macrophage apoptosis through a variety of ways, by either inducing or inhibiting apoptosis after infection. However, the molecular mechanisms of host cell apoptosis induction or inhibition are still not well understood. Therefore, the identification of apoptosis-related genes in the genome of MTB is necessary to investigate the details of this host-pathogen interaction and may be useful for the development of new drug targets and/or vaccine candidates., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=TVSI/IyFHHOEjCD9swMtCQ==, pdfFileSize=424454, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242118485799670473, articleId=1242118483073368434, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=结核分枝杆菌对宿主细胞凋亡效应的调控研究, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=由结核分枝杆菌（MTB）引起的结核病是严重危害人类健康的重大传染病，全世界约有1/3的人口潜伏感染MTB。近几年随着耐多药MTB和HIV混合感染的流行，使结核病控制形势更加严峻。细胞凋亡是生物有机体一种古老的免疫防御反应，在帮助机体清除胞内菌过程中发挥关键作用。已有研究结果表明，结核分枝杆菌对宿主细胞凋亡的调控过程非常复杂，即表现为有双重性：有些基因能促进凋亡，而有些则表现为抑制效应，且本研究组初步的研究结果表明细菌的毒力与凋亡有一定的内在联系，但是相关的分子机制还很不清楚。因此，鉴定MTB基因组中与凋亡相关的基因可以为研究细菌和宿主细胞之间的相互作用奠定基础，并且有助于研发新的药物靶标和候选疫苗。, authors=黄新华，何思为，李晨潇，王德成, authorsList=黄新华;何思为;李晨潇;王德成, authorCompany=复旦大学上海医学院；医学分子病毒学教育部/卫生部重点实验室，上海 200032, correspAuthors=null, authorNote=null, correspAuthorsNote=王德成, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=8a3gUZfsn7pbqtDz7TnjOg==, pdfFileSize=424454, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242118484985971062, 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