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科技导报
|研究论文
2009
, 27
(0923) :
82
-85
葛花对酒后血中乙醇浓度和肝中乙醇脱氢酶活性的影响
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李萍1 ,钟赣生2
作者信息
1. 艾美仕市场调研咨询(上海)有限公司北京分公司,北京 1000202. 北京中医药大学基础医学院,北京 100029
通讯作者:
钟赣生
Effects of Pueraria lobata (Willd.) Ohwi on Alcohol Content in Blood and Activity of Alcohol Dehydrogenase (ADH) of Animals After Drinking Alcohol
Affiliations
出版时间: 2009-12-13
文章导航
为了探讨葛花对急性酒精中毒的防治作用,将雄性小鼠随机分为空白组、模型组、葛花提取物组。给药30 min后,模型组与葛花组灌酒0.10 mL/10 g-1,在灌酒后0.5,1,1.5,2,2.5,3 h分别摘眼球取血和取肝组织。采用生化酶法测定小鼠酒后不同时间内血中乙醇浓度和肝中乙醇脱氢酶(ADH)活性。结果显示,小鼠血中乙醇浓度在酒后0.5~2 h达到高峰,与模型组相比,葛花提取物组0.5~3 h内的血中乙醇浓度数值降低。葛花提取物组对小鼠酒后0.5~1 h肝中ADH的影响较为明显,使其活性增加;酒后1.5~3 h肝中ADH活性虽然也增强,但与模型组比较无显著差异。结果显示,葛花提取物可降低酒后血中乙醇浓度,增强肝中ADH活性,其机制可能是通过抑制消化道对乙醇的吸收,从而起到有效的降醇解酒作用。
葛花
/
酒精中毒
/
解酒
/
乙醇浓度
/
乙醇脱氢酶活性
To observe the effect of Pueraria lobata (Willd.) Ohwi on relief of alcohol toxicity by animal experiments, female NIH mice were ovariectomized and randomly divided into 5 groups. The animal models of acute alcoholism were duplicated by force-feeding them with liquor "er guo tou". The influence of aqueous extract of Pueraria lobata (Willd.) Ohwion on the alcohol concentration in blood within 0.5~3 hours was studied by methods of biochemistry. The alcohol concentration in blood took the highest value in 0.5~1.5 hours. Compared to the model group, the alcohol concentration in blood for the group of aqueous extract of Pueraria lobata (Willd.) Ohwi is decreased in 0.5~3 hours; the activity of ADH in the liver is increased in 2~3 hours (P>0.05), while it is significantly increased in the first 0.5~1 hours (P<0.05). The aqueous extract of Pueraria lobata (Willd.) Ohwi could reduce the alcohol concentration in blood of animals after being fed with alcohol and increase the activity of ADH. It relieves alcohol toxicity and prevents drunkenness by restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the liver.
Pueraria lobata (Willd.) Ohwion
/
alcoholism
/
relieving alcohol
/
alcohol concentration
/
activity of alcohol dehydrogenase
李萍;钟赣生.
葛花对酒后血中乙醇浓度和肝中乙醇脱氢酶活性的影响.
科技导报,
2009
, 27
(0923)
: 82
-85
.
.
Effects of Pueraria lobata (Willd.) Ohwi on Alcohol Content in Blood and Activity of Alcohol Dehydrogenase (ADH) of Animals After Drinking Alcohol[J].
Science & Technology Review ,
2009
, 27
(0923)
: 82
-85
.
2009年第27卷第0923期
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接收时间:2009-09-23
首发时间:2009-12-13
出版时间:2009-12-13
收稿日期:2009-09-23
修回日期:2009-11-22
https://castjournals.cast.org.cn/joweb/kjdb/CN/1242118475263578786
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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