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科技导报
|2004年诺贝尔奖成果介绍专题
2005
, 23
(0502) :
22
-25
泛素调节的蛋白质降解——2004年诺贝尔化学奖成果简介
全屏
焦姣,姚祝军
作者信息
UBIQUITIN-MEDIATED PROTEOLYSIS——INTRODUCTION OF ACHIEVEMENTS OF THE NOBEL PRIZE IN CHEMISTRY 2004
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出版时间: 2005-02-10
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以色列科学家阿龙·切哈诺沃( Aaron Ciechanover)、阿夫拉姆·赫什科( Avram Hershko)和美国科学家欧文·罗斯( Irwin Rose)因发现泛素调节的蛋白质降解被授予 2004 年诺贝尔化学奖。泛素是一种含 76 个氨基酸的多肽,存在于除细菌外的许多不同组织和器官中,具有标记待降解蛋白质的作用。被泛素标记的蛋白质在蛋白酶体中被降解。泛素控制的蛋白质降解具有重要的生理意义,它不仅能够清除错误蛋白质,对细胞生长周期、 DNA 复制以及染色体结构都有重要的调控作用。
诺贝尔化学奖
/
泛素
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蛋白质降解
/
基因
/
癌症
The Nobel Prize in Chemistry 2004 is shared among three scientists who have madefundamental discoveries concerning how cells regulate the breakdown of intracellular proteins with extreme specificity as to target, time and space. Aaron Ciechanover, Avram Hershko and Irwin Rose together discovered ubiquitin-mediated proteolysis, a process where an enzyme system tags unwanted proteins with many molecules of the 76-amino acid residue protein ubiquitin. The tagged proteins are then transported to the proteasome, a large multisubunit protease complex, where they are degraded. Numerous cellular processes regulated by ubiquitin-mediated proteolysis include the cell cycle, DNA repair and transcription, protein quality control and the immune response. Defects in this proteolysis have a causal role in many human diseases, including a variety of cancers.
Nobel Prize in Chemistry
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ubiquitin
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proteolysis
/
gene
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cancer CLC Numbers: O629.72 Q519
焦姣;姚祝军.
泛素调节的蛋白质降解——2004年诺贝尔化学奖成果简介.
科技导报,
2005
, 23
(0502)
: 22
-25
.
.
UBIQUITIN-MEDIATED PROTEOLYSIS——INTRODUCTION OF ACHIEVEMENTS OF THE NOBEL PRIZE IN CHEMISTRY 2004[J].
Science & Technology Review ,
2005
, 23
(0502)
: 22
-25
.
2005年第23卷第0502期
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接收时间：2009-08-19
首发时间：2005-02-10
出版时间：2005-02-10
收稿日期：2009-08-19
修回日期：1900-01-01
https://castjournals.cast.org.cn/joweb/kjdb/CN/1242118180777295966
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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