Article(id=1242118072035771002, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242117794456732041, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1241452800000, receivedDateStr=2009-05-05, revisedDate=-2209017600000, revisedDateStr=1900-01-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1144598400000, onlineDateStr=2006-04-10, pubDate=1144598400000, pubDateStr=2006-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1144598400000, onlineIssueDateStr=2006-04-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073625809, creator=sys-migrate, updateTime=1774073625809, updator=sys-migrate, issue=Issue{id=1242117794456732041, tenantId=1146029695717560320, journalId=1146031591421210625, year='2006', volume='24', issue='0604', pageStart='1', pageEnd='94', issueExtLink='null', onlineDate='null', pubDate='1144598400000', pubDateStr='2006-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073559629, creator='sys-migrate', updateTime=1774073559629, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=48, endPage=50, ext={EN=ArticleExt(id=1242118076259435167, articleId=1242118072035771002, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Preliminary Study on the Apoptosis by Treating Human Osteosarcome MG-63 with As2O3 Combined with FP99, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=FP99 is an active substance from nightshade. We found the proliferation of MG-63 cells was inhibited by FP99 combined with As2O3 through MTT assay. In addition, the results indicated that the percent of apoptosis was elevated after treated by As2O3 combined with FP99 in MG-63 cells. To account for the mechanism of apoptosis in MG-63 cell, the detection of Caspase-3 activity was performed. The results indicated that the activity of Caspase-3 was increased after treated with As2O3 combined with FP99. We conclude that As2O3 combined with FP99 elevated apoptosis in MG-63 cell through increasing activation of Caspase-3., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=3TRmuSuZdNRzi7nzjSKtnA==, pdfFileSize=429182, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242118074640437257, articleId=1242118072035771002, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=As2O3联合FP99诱导骨肉瘤细胞MG-63凋亡的初步研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=采用噻唑蓝(MTT)法发现FP99能够协同三氧化二砷(As2O3)抑制人骨肉瘤细胞MG-63的生长,并采用流式细胞计数进一步证实FP99加强As2O3对MG-63细胞凋亡的诱导作用;进而检测了Caspase-3的活性,发现As2O3联合FP99作用MG-63细胞后,Caspase-3的活性显著提高,提示我们As2O3联合FP99增加MG-63细胞的凋亡率的机制可能是通过提高Caspase-3激酶活性,从而促进了整个凋亡通路的激活,最终导致细胞凋亡的增加。, authors=肖涛^1，2,李康华³,方建珍²,王万春²,李桂源 ¹, authorsList=肖涛;李康华;方建珍;王万春;李桂源, authorCompany=1. 中南大学湘雅医学院 长沙2. 中南大学湘雅二医院 长沙3. 中南大学湘雅医院 长沙, correspAuthors=null, authorNote=null, correspAuthorsNote=肖涛, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=vvXYDZYvTZvanq9W8T4x2Q==, pdfFileSize=429182, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242118073747047055, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242118072035771002, 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