Article(id=1242117893199037299, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242117870927286391, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1250524800000, receivedDateStr=2009-08-18, revisedDate=-2209017600000, revisedDateStr=1900-01-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1160409600000, onlineDateStr=2006-10-10, pubDate=1160409600000, pubDateStr=2006-10-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1160409600000, onlineIssueDateStr=2006-10-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073583170, creator=sys-migrate, updateTime=1774073583170, updator=sys-migrate, issue=Issue{id=1242117870927286391, tenantId=1146029695717560320, journalId=1146031591421210625, year='2006', volume='24', issue='0610', pageStart='1', pageEnd='86', issueExtLink='null', onlineDate='null', pubDate='1160409600000', pubDateStr='2006-10-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073577858, creator='sys-migrate', updateTime=1774073577858, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=37, endPage=41, ext={EN=ArticleExt(id=1242117896076333326, articleId=1242117893199037299, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Experimental Investigation of Suppressive Effect of Saikosaponin-d on the Progression of Glomerulosclerosis, columnId=1242117841617489931, journalTitle=Science & Technology Review, columnName=实验技术, runingTitle=null, highlight=null, articleAbstract=Objective: The preventive effects of Saikosaponin-d (Ssd ) on the progression of mesangioproliferation and glomerulosclorosis, induced by intravenous injection of anti-Thy1 monoclonal antibody (mAb) 1-22-3 into uninephrectomized rats, were evaluated. Methods: Eighteen rats were divided into three groups of six. One group was treated with phosphate buffered saline (PBS) as a control. The other two groups were treated with Ssd 1.8 mg/kg body weight (BW)./day or 0.6mg/kg BW/day respectively. Urine samples were collected from the rats in metabolic cages on days 1, 4, 8, 14 and 21 after the injection of mAb 1-22-3. Systolic BP(SBP) was tested on days 1, 5, 10, 14 and 18 after the injection. All rats were sacrificed 21 days after the injection of mAb 1-22-3 for blood biochemistry, and immunofluorescent and light microscopy of the kidneys. Results: Ssd suppressed proteinuria, extracellular matrix expansion, crescentic formation as well as inflammatory cell infiltration. Especially, Ssd was sh...更多own to have highly significant suppressive effect on CD8+T cells infiltration into the periglomerular and tubulointerstitial areas and on expression of TGF-a type I collagen in the kidneys and α-SMA along Bowman's capsule. Conclusions: Our study indicates that Ssd could prevent initiation and progression of mesangioproliferative glomerulonephritis in rats through inhibition of CD8+ T cell infiltration, macrophage accumulation and activation, and expression of TGF- and type I collagen in the kidneys., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=IMYprhyTciMkgLs7DuFgZw==, pdfFileSize=1704603, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242117894767707010, articleId=1242117893199037299, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=柴胡皂苷-d防治大鼠肾小球硬化的实验研究, columnId=1242117840715714561, journalTitle=科技导报, columnName=实验技术, runingTitle=null, highlight=null, articleAbstract=目的:观察柴胡皂苷-d对一侧肾切除加单克隆抗体1-22-3注射造成进行性大鼠肾小球硬化的防治作用。方法:18只大鼠一侧肾切除1d后,尾静脉注射单克隆抗体1-22-3造成大鼠进行性肾小球硬化。随机分为3组,每组6只。第一组给生理盐水作对照,另外两组分别腹腔注射柴胡皂苷-d1.8mg和0.6mg/kg体重/d。在代谢笼内取大鼠造模后第1、4、8、14和21d尿液,并动态观察造模后第1、5、10、14和18d收缩压变化。21d后处死全部大鼠,进行血生化和肾组织光学显微镜检查,并利用RT-PCR和免疫荧光的方法分析了药物对炎症硬化因子TGF-β、I型胶原、"-平滑肌肌动蛋白("-SMA)和炎症细胞在肾小球和肾小管间质表达与分布的影响。结果:柴胡皂苷-d在减轻肾小球病理损害的同时,抑制了TGF-β在肾小球内的表达和a-SMA沿鲍曼氏囊的分布。柴胡皂苷-d治疗组CD8+T细胞和巨噬细胞在肾小球周围和肾小管间质的浸润也明显减轻。结论:柴胡皂苷-d能够有效地防治大鼠肾小球硬化,可能与抑制了TGF-β在肾小球内的表达和炎症细胞在肾小球和肾小管间质浸润有关。, authors=李平¹,巩跃文²,赵世萍¹,李克明¹,陈玉武¹,付桂香¹,郭景珍¹,李忻¹,张韫¹, authorsList=李平;巩跃文;赵世萍;李克明;陈玉武;付桂香;郭景珍;李忻;张韫, authorCompany=1. 中日友好医院 北京2. 加拿大马尼托巴大学药学院 温尼伯格, correspAuthors=null, authorNote=null, correspAuthorsNote=李平, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=wu6RplzgWfodbGO4lWYdJw==, pdfFileSize=1704603, pdfExtLink=null, 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