Article(id=1242117687531339854, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242117680468131883, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1252857600000, receivedDateStr=2009-09-14, revisedDate=1255881600000, revisedDateStr=2009-10-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1258041600000, onlineDateStr=2009-11-13, pubDate=1258041600000, pubDateStr=2009-11-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1258041600000, onlineIssueDateStr=2009-11-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073534134, creator=sys-migrate, updateTime=1774073534134, updator=sys-migrate, issue=Issue{id=1242117680468131883, tenantId=1146029695717560320, journalId=1146031591421210625, year='2009', volume='27', issue='0921', pageStart='1', pageEnd='140', issueExtLink='null', onlineDate='null', pubDate='1258041600000', pubDateStr='2009-11-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073532452, creator='sys-migrate', updateTime=1774073532452, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=24, endPage=31, ext={EN=ArticleExt(id=1242117690421215339, articleId=1242117687531339854, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Preparation and Self-assembly of Biocompatible Polyrotaxane and Hemolysis Evaluation of Amphotericin B After Being Loaded by the Self-assembly, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=A kind of novel amphiphilic triblock copolymers containing polyrotaxane (PR) as a central block was synthesized via the ATRP of poly(ethylene glycol) methyl ether methacrylate (PEGMA) initiated with polypseudorotaxanes made from a distal 2-bromopropionyl end-capped Pluronic F127 with a varying amount of β-CDs in the presence of CuCl/N,N,N',N'',N''- pentamethyldiethylenetriamine(PMDETA) at 25℃ in an aqueous medium. The structure of the resulting copolymers was characterized in detail by 1H-NMR, GPC and DSC analyses. As a typical sample, F-30β-CD-60 was found to be self-assembled into nano-sized aggregates in water. Its critical aggregation concentration was estimated by the fluorescence probe technique. The transmission electron microscopy images further revealed that the sizes of the polymeric micelles of this selected copolymer were in nano-scale and smaller than those of the blank brush-like block copolymer. These nano-sized particles showed a great potential to be used as carrier for the controlled release of Amphotericin B(AmB) with 8.7% drug-loading content and 87 % drug-loading efficiency. And it is also true that the hemolysis of AmB has been significantly decreased after being loaded by the self-assembly., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=3E5d43FO4ni6Iwi+YjclnA==, pdfFileSize=1228356, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242117689385226660, articleId=1242117687531339854, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=生物相容性聚轮烷合成、自组装和对两性霉素B的溶血性能降低作用研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=利用经典原子转移自由基聚合法（ATRP）合成了一系列以PluronicF127-β-环糊精（β-CD）包合物为中心，聚端甲基多缩乙二醇甲基丙烯酸酯（PPEGMA）为大的封端基团的主链型三嵌段聚轮烷。实验过程中，利用2-溴异丙酰化的Pluronic F127-β-CDs自组装所得到的聚准轮烷为大分子引发剂，用CuCl/PMDETA作为催化剂，在水相体系中，室温（25℃）下引发大分子单体端甲基多缩乙二醇甲基丙烯酸酯（PEGMA）在准轮烷两端进行聚合，成功合成了具有管道结晶疏水的中间链段和亲水聚合物端基的聚轮烷。文中分别用1H-NMR，GPC和DSC对合成的聚轮烷的性质进行了表征。由于其特殊亲疏水的嵌段结构，本文中制备的聚轮烷能够在水中自组装形成聚集体，以F-30β-CD-60样品为例，对其自组装性能以及对两性霉素B（AmB）的溶血性能降低作用进行了研究。结果表明，经F-30β-CD-60自组装体对AmB有很高的药物包覆量（8.7%）及药物包覆率（87%），且经包覆的AmB溶血性能明显降低，表明自组装体能够有效降低AmB的溶血毒性。其临界聚集浓度（CAC）利用荧光探针法进行了测定，同时用透射电镜（TEM）对聚集体的形貌进行了观察。, authors=张晓雯,冯增国, authorsList=张晓雯;冯增国, authorCompany=北京理工大学材料科学与工程学院, correspAuthors=null, authorNote=null, correspAuthorsNote=张晓雯, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=kmxPKk43DKR+qkSmA0JFmA==, pdfFileSize=1228356, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, 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