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Sixty ASA I or II patients aged 25~55 years undergoing elective laparoscopic cholecystectomy under TIVA were randomly divided into 4 groups (n=15 for each group): group A propofol; group B propofol + (the target plasma concentration of) 2 ng/mL remifentanil; group C propofol + 4 ng/mL remifentanil; group D propofol + 6 ng/mL remifentanil. Propofol was delivered by TCI at the target plasma concentration of 3 ?滋g/mL during introduction of anesthesia, and was adjusted according to BIS maintained between 40 and 60 during surgery. Rocuronium 0.6 mg/kg was given intravenous. to facilitate tracheal intubation. N-M function was monitored and recorded using acceleromyography (TOF-GUARD, Organon Teknika B.V.). The force of thrum adduction in response to single and TOF stimulation of ulnar nerve was recorded. The onset time of N-M block was compared among the four groups ranging from 54 to 57 seconds. The duration of N-M block, the 75% recovery time and the recovery indexes among groups saw no significant difference. The results show that TCI different concentration of remifentanil has no synergistic effect on rocuronium induced N-M block. It is suggested that the mechanism of remifentanil reducing the requirements of rocuronium in total intravenous anesthesia is due to the effect on CNS., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=3iWB3zlrfAM2KC6s544ovQ==, pdfFileSize=460856, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242117249528565833, articleId=1242117245481062429, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=全凭静脉麻醉下不同效应室浓度瑞芬太尼对罗库溴铵肌松作用的影响, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=评价瑞芬太尼对全凭静脉麻醉病人罗库溴铵肌松作用起效、维持和恢复时间的影响。选择60例腹腔镜胆囊切除术病人,年龄25~55岁,ASA I或II级。随机分为4组(每组n=15),A组:不用瑞芬太尼;B组:瑞芬太尼效应室浓度2 ng/mL;C组:瑞芬太尼效应室浓度4 ng/mL;D组:瑞芬太尼效应室浓度6 ng/mL。每组靶控输注异丙酚全麻诱导的血药浓度均为3 ?滋g/mL。术中根据脑电双频谱指数BIS值调整异丙酚的效应室浓度,麻醉深度维持在BIS值为40~60。观察并记录静脉注射插管剂量(2×ED95)的罗库溴铵后各组病人肌松起效、维持和恢复时间。结果显示,4组病人的罗库溴铵的肌松作用起效、维持和恢复时间的比较差异无统计学意义(P>0.05)。故得出结论:全凭静脉麻醉中靶控输注瑞芬太尼与罗库溴铵没有协同作用,瑞芬太尼减少静脉全麻中肌松药用量的作用机制是中枢性的。, authors=赵秋华,朱俊峰,赵立波,郑侃, authorsList=赵秋华;朱俊峰;赵立波;郑侃, authorCompany=北京市石景山医院麻醉科, correspAuthors=null, authorNote=null, correspAuthorsNote=赵秋华, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=LYOJjiBPXJoJexYRRO8y+w==, pdfFileSize=460856, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, 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科技导报 |研究论文 2009 , 27 (0918) : 101 -103
全凭静脉麻醉下不同效应室浓度瑞芬太尼对罗库溴铵肌松作用的影响
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赵秋华,朱俊峰,赵立波,郑侃
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    北京市石景山医院麻醉科
通讯作者:
赵秋华
Effects of Remifentanil on Rocuronium-induced Neuromuscular Block
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    出版时间: 2009-09-28
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    评价瑞芬太尼对全凭静脉麻醉病人罗库溴铵肌松作用起效、维持和恢复时间的影响。选择60例腹腔镜胆囊切除术病人,年龄25~55岁,ASA I或II级。随机分为4组(每组n=15),A组:不用瑞芬太尼;B组:瑞芬太尼效应室浓度2 ng/mL;C组:瑞芬太尼效应室浓度4 ng/mL;D组:瑞芬太尼效应室浓度6 ng/mL。每组靶控输注异丙酚全麻诱导的血药浓度均为3 ?滋g/mL。术中根据脑电双频谱指数BIS值调整异丙酚的效应室浓度,麻醉深度维持在BIS值为40~60。观察并记录静脉注射插管剂量(2×ED95)的罗库溴铵后各组病人肌松起效、维持和恢复时间。结果显示,4组病人的罗库溴铵的肌松作用起效、维持和恢复时间的比较差异无统计学意义(P>0.05)。故得出结论:全凭静脉麻醉中靶控输注瑞芬太尼与罗库溴铵没有协同作用,瑞芬太尼减少静脉全麻中肌松药用量的作用机制是中枢性的。
    哌啶类  /  雄甾烷醇类  /  二异丙酚  /  神经肌肉阻滞
    The effect of remifentanil given by Target-Controlled Infusion (TCI) on rocuronium-induced neuromuscular (N-M) block during Total Intravenous Anesthesia (TIVA) is investigated. Sixty ASA I or II patients aged 25~55 years undergoing elective laparoscopic cholecystectomy under TIVA were randomly divided into 4 groups (n=15 for each group): group A propofol; group B propofol + (the target plasma concentration of) 2 ng/mL remifentanil; group C propofol + 4 ng/mL remifentanil; group D propofol + 6 ng/mL remifentanil. Propofol was delivered by TCI at the target plasma concentration of 3 ?滋g/mL during introduction of anesthesia, and was adjusted according to BIS maintained between 40 and 60 during surgery. Rocuronium 0.6 mg/kg was given intravenous. to facilitate tracheal intubation. N-M function was monitored and recorded using acceleromyography (TOF-GUARD, Organon Teknika B.V.). The force of thrum adduction in response to single and TOF stimulation of ulnar nerve was recorded. The onset time of N-M block was compared among the four groups ranging from 54 to 57 seconds. The duration of N-M block, the 75% recovery time and the recovery indexes among groups saw no significant difference. The results show that TCI different concentration of remifentanil has no synergistic effect on rocuronium induced N-M block. It is suggested that the mechanism of remifentanil reducing the requirements of rocuronium in total intravenous anesthesia is due to the effect on CNS.
    piperidines  /  androstanols  /  propofol  /  neuromuscular blockade
    赵秋华;朱俊峰;赵立波;郑侃. 全凭静脉麻醉下不同效应室浓度瑞芬太尼对罗库溴铵肌松作用的影响. 科技导报, 2009 , 27 (0918) : 101 -103 .
    . Effects of Remifentanil on Rocuronium-induced Neuromuscular Block[J]. Science & Technology Review, 2009 , 27 (0918) : 101 -103 .

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    2种不同金属材料的力学参数

    Family
    属数
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    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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