Article(id=1242116798183707245, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242116066525118632, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1240156800000, receivedDateStr=2009-04-20, revisedDate=1244563200000, revisedDateStr=2009-06-10, acceptedDate=null, acceptedDateStr=null, onlineDate=1246118400000, onlineDateStr=2009-06-28, pubDate=1246118400000, pubDateStr=2009-06-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1246118400000, onlineIssueDateStr=2009-06-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073322095, creator=sys-migrate, updateTime=1774073322095, updator=sys-migrate, issue=Issue{id=1242116066525118632, tenantId=1146029695717560320, journalId=1146031591421210625, year='2009', volume='27', issue='0912', pageStart='3', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1246118400000', pubDateStr='2009-06-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073147655, creator='sys-migrate', updateTime=1774073147655, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=28, endPage=33, ext={EN=ArticleExt(id=1242116803556610700, articleId=1242116798183707245, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Establishment of the Model of Co-effect of Multi-factor and Abnormal Savda Syndrome in Uighur Medicine, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=Objective: Study the relationship between co-effect of multi-factor and establishment of the model of abnormal savda syndrome in Uighur medicine, observe the immunological indicators and the changes of functional indicators of Hypothalamus - pituitary - adrenal axis. Methods:45 healthy male ICR mice were randomly divided into normal control group, twi-factor group, and tri- factor group. Twi-factor group was stressed with intermittent foot shock, the output voltage 40 ± 5V, changing the voltage from time to time, interval 0.2 ~ 0.5s, continuous stimulation 20mins everyday, and placed in cold Phytotron (temperature 10 ± 1 ℃, relative humidity 36 ~ 40%) for 10 hours/day ,and finally made it produce chronic stress.Tri- factor group was stressed with intermittent foot shock in cold Phytotron (temperature 10 ± 1 ℃, relative humidity 36 ~ 40%),and were fed dry and cool food, and the period lasted 21 days. We observed the change of biological characterization of each group, and the cell percentages of CD4 + and CD8 + in experimental mice's peripheral blood were measured by flow cytometry ,and the contents of IL-2, IL-6, IFN-γ, TNF-α, IgM, IgG, IgA in the miceˊs serum were examined by ELISA on the 21th day. Results: Compared to control group, tri-factor group showed petechiae, small moss, dark purple of tongue; fur lackluster，curled，reduced sensitivity to stimulation，slow response; lassitude somnolence ,frequent arousals; more diet,more drink，forming stool，cervine urine on the 21th day. The percentage of CD4+ and the percentage of CD8+decreased (P＜0.01), the CD4+/CD8+ratio decreased (P＜0.05) in peripheral blood; the contents of IFN-γ and IL-2 decreased significantly in serum (P <0.01),TNF-α and IL-6 increased significantly ( P <0.01), IgM and IgG increased significantly ( P <0.01),however,IgA decreased significantly ( P <0.01) ,. Twi-factor group showed lavender apex of tongue; fur lackluster, curled,tiredness indifferent, reduced sensitivity to stimulation, slow to react, more diet,more drink, forming and stool wet, pale colour of urine on the 21th day . The percentage of CD4+decreased (P＜0.01), The percentage of CD8+ had no significant difference (P＞0.05), CD4+/CD8+ratio decreased (P＜0.01) in peripheral blood; compared to normal control group,the content of IL-2 in serum decreased significantly (P <0.01), IL-6 had no significant difference（P＞0.05） , INF-γdecreased significantly（P＜0.01） , TNF-αincreased significantly（P＜0.01）, IgM, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=JBdMZUFRBAL8wdDOqQrmow==, pdfFileSize=582304, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242116801329435263, articleId=1242116798183707245, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=多因素复合作用与维医异常黑胆质证候模型建立的关系研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=目的：研究多因素复合作用与维医异常黑胆质证侯模型建立的关系，并观察其免疫功能的变化。方法：选用健康雄性ICR小鼠45只，随机分成正常对照组、双因素组和三因素组。双因素组采用间断足底电击作为应激源，输出电压40±5V ，不定时改变电压，间隔0.2～0.5s，每天连续刺激20min，并置于人工气候箱（温度10±1℃，相对湿度36～40%）干寒的饲养环境10小时/天，产生慢性应激共21天。三因素组采用间断足底电击作为应激源，置于人工气候箱干寒（温度10±1℃，相对湿度36～40%），并给予干寒属性饲料喂养，共21天。第21天观察各组小鼠生物表征的变化并取实验动物外周血，应用流式细胞仪测定小鼠外周血CD4+、CD8+细胞百分比含量， ELISA法测定小鼠血清IL-2、IL-6、IFN-γ、TNF-α、IgM、IgG和IgA含量。结果：与正常组相比，三因素组实验动物第21天出现舌干暗紫，有瘀斑，少苔；皮毛黯淡无光泽，蜷缩少动，对刺激敏感度降低，反应迟缓；倦怠嗜睡，易惊；争食饮水，大便成形，小便色浅黄。外周血T淋巴细胞亚群CD4+与CD8+细胞百分比明显下降（P＜0.01），CD4+/CD8+比值下降（P＜0.05）；血清中IL-2与INF-γ含量明显降低（P＜0.01），IL-6与TNF-α的含量明显升高（P＜0.01）；血清中IgM与IgG的含量明显升高(P＜0.01）；而血清中IgA含量明显降低(P＜0.01）。双因素组实验动物第21天出现舌有瘀苔滑；皮毛暗淡无光泽、蜷缩少动，扎堆眯眼，倦怠淡漠，对刺激敏感度降低，反应迟缓，争食饮水，大便成形而湿，小便色清。外周血T淋巴细胞亚群CD4+细胞百分比下降（P＜0.01），CD8+细胞百分比未见明显差异（P＞0.05），CD4+/CD8+比值下降（P＜0.01）；血清中IL-2的含量明显降低（P＜0.01），血清中IL-6的含量未见明显差异（P＞0.05），血清中INF-γ含量明显降低（P＜0.01），血清中TNF-α的含量明显升高（P＜0.01）。血清中IgM的含量明显升高 (P＜0.01），IgG的含量明显高于正常对照组(P＜0.01），IgA含量明显低于正常对照组(P＜0.01）。与三因素组相比，双因素组实验动物外周血T淋巴细胞亚群CD4+细胞百分比未见显著差异，CD8+细胞百分比上升（P＜0.01），CD4+/CD8+比值下降（P＜0.05）。血清中IL-2含量升高(P＜0.05）；IL-6含量明显降低(P＜0.01）； IFN-γ与TNF-α的含量未见显著性差异（P＞0.05）；血清中IgM的含量明显降低(P＜0.01）；IgG与IgA含量未见明显差异(P＞0.05）；结论：⑴与正常对照组比较，三因素复合作用后模型动物表现出的生物表征变化更加符合人体异常黑胆质证侯临床表现，三因素复合作用组不仅有生物表征的改变，同时有免疫功能的紊乱。⑵双因素复合作用模型动物在相同时间段表现出的生物表征、免疫功能紊乱与三因素复合作用组相比有程度上的差异，且尚不完全符合人体异常黑胆质证侯临床表现。⑶结合干寒环境、不良精神刺激、干寒属性食物等多因素复合作用所建立的异常黑胆质证侯动物模型不仅符合人体异常黑胆质证侯临床表现，而且具有稳定性和可靠性。, authors=罗玲娟¹,哈木拉提·吾甫尔²,阿地里江·阿布力米提², authorsList=罗玲娟;哈木拉提·吾甫尔;阿地里江·阿布力米提, authorCompany=1. 新疆医科大学中医学院2. 新疆医科大学维吾尔医药系, correspAuthors=null, authorNote=null, correspAuthorsNote=罗玲娟, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2BV8/QiFYwtX+B6YH07KtQ==, pdfFileSize=582304, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242116800742228227, tenantId=1146029695717560320, 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