Article(id=1242116072363594244, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242116071021416959, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1240156800000, receivedDateStr=2009-04-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1247414400000, onlineDateStr=2009-07-13, pubDate=1247414400000, pubDateStr=2009-07-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1247414400000, onlineIssueDateStr=2009-07-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774073149046, creator=sys-migrate, updateTime=1774073149046, updator=sys-migrate, issue=Issue{id=1242116071021416959, tenantId=1146029695717560320, journalId=1146031591421210625, year='2009', volume='27', issue='0913', pageStart='1', pageEnd='140', issueExtLink='null', onlineDate='null', pubDate='1247414400000', pubDateStr='2009-07-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774073148726, creator='sys-migrate', updateTime=1774073148726, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=7, endPage=6, ext={EN=ArticleExt(id=1242116081981128905, articleId=1242116072363594244, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Metabonomic Studies on Abnormal Savda Syndrome Patients with Neoplasm Using NMR Spectroscopy, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=This paper studies metabonomic changes in plasma of Abnormal Savda syndrome patients with neoplasm based on the theory of Traditional Uighur Medicine. A 1H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed on plasma samples obtained from 223 cases of Abnormal Savda syndrome patients with neoplasm and 50 healthy volunteers, and the data were analyzed using Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA). The results show that in plasma of Abnormal Savda syndrome patients with neoplasm, a wide range of amino acids including Leucine, Alanin, Citruline, Tyrosine, Histidine, Glycine, Methionine, Isoleucine, Valine, Acetylcysteine see a significant decrease(P<0.05) and Glycoprotein, Glutamine, Myo-inositol, Lactic acid, Choline Creatine are also decreased (P<0.05). Formic acid, Acetone, Acetic acid, Acetoacetate, Pyruvate, β-Hydrocxy butyrate, Carnitine, Malonic acid are increased as compared with healthy plasma metabolites (P<0.05). It is concluded that in Abnormal Savda syndrome patients with neoplasm, lipid metabolism-related metabolites are increased, with abnormal amino acid metabolism, cytoplasm membrane defects, oxidative damage due to abnormal antioxidation ability. These findings indicate that the Abnormal Savda syndrome may be accompanied with imbalance of endocrine dysfunction of the body, low immune function, structural changes of protein, carbohydrates, nucleic acid, biological macromolecules, membrane lipid peroxidation, membrane protein and receptor variability, which will be followed by various diseases such as neoplasm., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=tNTMrinS+wvEEBuL7g+/AQ==, pdfFileSize=627388, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242116080974500391, articleId=1242116072363594244, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=基于NMR的维吾尔医异常黑胆质型肿瘤患者血浆代谢组学分析, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=探讨了异常黑胆质型体液引起肿瘤过程中体内代谢变化的机理。对223例异常黑胆质型肿瘤患者和50例健康人血浆进行核磁共振氢谱检测，分段积分后采用正交偏最小二乘判别（ＯPLS-DA）分析。结果表明，异常黑胆质型肿瘤患者血浆中多种氨基酸显著下降，包括亮氨酸、丙氨酸、瓜氨酸、酪氨酸、组氨酸、甘氨酸、蛋氨酸、异亮氨酸、缬氨酸等，与健康人比较差异有统计学意义（P<0.05）。此外，糖蛋白、谷氨酰胺、肌醇、乳酸、胆碱、肌酸也显著下降，与健康人比较差异有统计学意义（P<0.05）。同时，异常黑胆质型肿瘤患者血浆中甲酸、丙酮、乙酸、乙酰乙酸、丙酮酸、β-羟丁酸、肉碱、丙二酸，以及脂肪分解产物多不饱和脂肪酸、极低密度脂蛋白、低密度脂蛋白等显著增加，与健康人比较差异有统计学意义（P<0.05）。由此表明，异常黑胆质型肿瘤患者体内脂肪动员加强，同时氨基酸代谢出现异常，细胞膜的完整性降低，机体抗氧化能力下降，使氧化损伤加剧。机体形成异常黑胆质时，很可能出现机体内分泌功能紊乱，免疫功能低下，膜蛋白和受体变性，从而引起肿瘤等各种疾病。, authors=艾斯克尔·吐拉洪¹,哈木拉提·吾甫尔²,豪富华³,巴吐尔·买买提明⁴, authorsList=艾斯克尔·吐拉洪;哈木拉提·吾甫尔;豪富华;巴吐尔·买买提明, authorCompany=1. 新疆医科大学第五附属医院2. 新疆医科大学维吾尔医药系3. 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室4. 新疆医科大学药学院, correspAuthors=null, authorNote=null, correspAuthorsNote=巴吐尔·买买提明, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, 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