Article(id=1229061626989572467, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1229061621834772825, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1770960726735, onlineDateStr=2026-02-13, pubDate=1770912000000, pubDateStr=2026-02-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1770825600000, onlineIssueDateStr=2026-02-12, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1770960726735, creator=13701087609, updateTime=1774080661420, updator=sys-migrate, issue=Issue{id=1229061621834772825, tenantId=1146029695717560320, journalId=1146031591421210625, year='2026', volume='44', issue='3', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='1770912000000', pubDateStr='2026-02-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1770960725506, creator='13701087609', updateTime=1774331256482, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1243198653456826622, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1229061621834772825, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1243198653456826623, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1229061621834772825, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4, endPage=4, ext={EN=ArticleExt(id=1229061627425780087, articleId=1229061626989572467, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=null, columnId=1157710593001177623, journalTitle=Science & Technology Review, columnName=Science and Technology News, runingTitle=null, highlight=null, articleAbstract=null, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=All rights reserved. Unauthorized reproduction is prohibited., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1229061627807461758, articleId=1229061626989572467, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=抗体人源化迎来“精准导航”, columnId=1157710593177338394, journalTitle=科技导报, columnName=科技新闻, runingTitle=null, highlight=null, articleAbstract=

治疗性抗体药物研发中，长期存在一个关键难题：若抗体来源于非人生物（如小鼠），进入人体后可能被免疫系统识别为“外来物”，从而引发免疫反应，导致药效下降，甚至出现不良反应。因此，抗体必须经过“人源化”改造，以降低其免疫原性、提升安全性。然而，传统方法往往依赖全局序列比对，难以精准定位导致免疫原性的具体氨基酸位点，改造过程犹如“大海捞针”，耗时耗力。

, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=版权所有，未经授权，不得转载。, copyrightOwner=《科技导报》编辑部, extLink=null, articleAbsUrl=null, sourceXml=YRveavLXXXKf8wSrHKLjdg==, magXml=YRveavLXXXKf8wSrHKLjdg==, pdfUrl=null, pdf=7F2oRpZ6QOSCKoF+70QCWw==, pdfFileSize=983821, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ZRCeI08B4k0jdr/QENCtdw==, mapNumber=null, fund=null)}, authors=null, keywords=null, refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1788948767789, createdBy=null, updatedBy=13041195026, firstLetterCn=K, firstLetterEn=K, subjectCode=Multidisciplinary, subjectName=null, subjectCodeEn=Multidisciplinary, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1304508939635282786, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1788948767813, updatedTime=1788948767813, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1304508939694003043, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1788948767827, updatedTime=1788948767827, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""}), JournalExt(id=1304508939635282786, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1788948767813, updatedTime=1788948767813, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1304508939694003043, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1788948767827, updatedTime=1788948767827, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdbold/CN, language=CHT, createTime=1751182263881, createBy=18614031015, updateTime=1778563538782, updateBy=18614031015, name=科技导报, tplId=1260949628132966587, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdbold/EN, language=CHT, createTime=1751182386363, createBy=18614031015, updateTime=1776048495217, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)]), Website(id=1242135128537874442, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1774077692406, createBy=18614031015, updateTime=1776048481053, updateBy=18614031015, name=科技导报other, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1242918134445884174, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=articleTextType, value=kx, createTime=1774264375554, updateTime=1774264375554, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134424912651, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=banner, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=DdYjdDiJ8taFWepWGZ5jQw==, createTime=1774264375549, updateTime=1774264375549, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134466855697, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=grayFlag, value=0, createTime=1774264375559, updateTime=1774264375559, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134412329738, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=SJqiJew4WTXky9kn2Wushw==, createTime=1774264375546, updateTime=1774264375546, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134479438611, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=minRunFlag, value=0, createTime=1774264375562, updateTime=1774264375562, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134441689869, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1774264375553, updateTime=1774264375553, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134471050002, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=silenceFlag, value=0, createTime=1774264375560, updateTime=1774264375560, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134433301260, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1774264375551, updateTime=1774264375551, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134454272783, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=themeColor, value=null, createTime=1774264375556, updateTime=1774264375556, creator=18614031015, updator=18614031015), WebsiteProps(id=1242918134458467088, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242135128537874442, code=themeStyle, value=null, createTime=1774264375557, updateTime=1774264375557, creator=18614031015, updator=18614031015)]), Website(id=1242172063583088667, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1774086498408, createBy=18614031015, updateTime=1776333765238, updateBy=18614031015, name=科技导报others, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1242176044736803639, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=articleTextType, value=kx, createTime=1774087447580, updateTime=1774087447580, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044715832116, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=banner, value=null, createTime=1774087447575, updateTime=1774087447575, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044766163770, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=grayFlag, value=0, createTime=1774087447587, updateTime=1774087447587, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044703249203, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1774087447572, updateTime=1774087447572, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044778746684, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=minRunFlag, value=0, createTime=1774087447590, updateTime=1774087447590, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044728415030, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1774087447578, updateTime=1774087447578, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044770358075, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=silenceFlag, value=0, createTime=1774087447588, updateTime=1774087447588, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044724220725, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1774087447577, updateTime=1774087447577, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044749386552, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=themeColor, value=null, createTime=1774087447583, updateTime=1774087447583, creator=18614031015, updator=18614031015), WebsiteProps(id=1242176044757775161, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1242172063583088667, code=themeStyle, value=null, createTime=1774087447585, updateTime=1774087447585, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=K, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/Y2026/V44/I3/4, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/Y2026/V44/I3/4, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/Y2026/V44/I3/4, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/Y2026/V44/I3/4, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1770912000000, fullTextJson=null, articleText=null, reference=null)