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像制导导弹般锁定癌细胞的工程化免疫细胞，能为患者带来生机——前提是他们能及时获得治疗。目前，T细胞需从患者体内采集，通过基因编辑添加嵌合抗原受体（CAR），这一实验室过程耗时长、费用高。直接在患者体内制造这些细胞将更快，早期临床数据表明，这一策略可行。在首批试验之一中，这种所谓体内CAR-T细胞在4例多发性骨髓瘤（一种血液癌）患者体内生成，并将恶性细胞从骨髓中清除。

, authors=null, authorsList=Mitch Leslie, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=版权所有，未经授权，不得转载。, copyrightOwner=《科技导报》编辑部, extLink=null, articleAbsUrl=null, sourceXml=5LezLOlZ9IYp2C1WVb/tqw==, magXml=5LezLOlZ9IYp2C1WVb/tqw==, pdfUrl=null, pdf=hLf9rw3rtiq/8wYoYq9S1g==, pdfFileSize=1596056, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=JVjAzke1zUYX/s/AR77TQw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=tIZcMvJGC03xU2JN4TG7tQ==, mapNumber=null, fund=null)}, authors=[Author(id=1242146593277817326, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1218130671223095322, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={CN=AuthorExt(id=1242146593340731888, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1218130671223095322, authorId=1242146593277817326, language=CN, stringName=Mitch Leslie, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)], keywords=null, refs=null, funds=null, companyList=null, figs=[ArticleFig(id=1242146593487532530, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1218130671223095322, language=EN, label=null, caption=null, figureFileSmall=DDnGZuk74r+Isnw7W0zytg==, figureFileBig=cpQkYRsEjv6L/K9f3hJQEQ==, tableContent=null), ArticleFig(id=1242146593550447091, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1218130671223095322, language=CN, label=null, caption=利用体内基因疗法生成带有受体（红色）的T细胞，精准锁定癌细胞

（图片来源：《Science》）

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