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拉曼光谱是材料科学、半导体工业、环境测试、考古学和生物医学的重要工具,但其应用的一个重要限制是荧光背景。由于拉曼信号和荧光信号同属光致发光现象,且光谱波长范围存在重叠,而荧光信号强度通常比拉曼信号强数个数量级,这使得荧光干扰问题尤为突出。时间门控拉曼光谱技术是区分微弱拉曼信号与强荧光背景的关键工具,但由于单光子雪崩二极管(SPAD)技术瓶颈,难以同时满足高光谱分辨率、宽光谱范围和高时间分辨率的需求。

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光子矩阵技术让拉曼信号从荧光背景中“显形”
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    拉曼光谱是材料科学、半导体工业、环境测试、考古学和生物医学的重要工具,但其应用的一个重要限制是荧光背景。由于拉曼信号和荧光信号同属光致发光现象,且光谱波长范围存在重叠,而荧光信号强度通常比拉曼信号强数个数量级,这使得荧光干扰问题尤为突出。时间门控拉曼光谱技术是区分微弱拉曼信号与强荧光背景的关键工具,但由于单光子雪崩二极管(SPAD)技术瓶颈,难以同时满足高光谱分辨率、宽光谱范围和高时间分辨率的需求。

    . 光子矩阵技术让拉曼信号从荧光背景中“显形”. 科技导报, 2025 , 43 (21) : 4 -4 .
    . Science & Technology Review, 2025 , 43 (21) : 4 -4 .
    拉曼光谱是材料科学、半导体工业、环境测试、考古学和生物医学的重要工具,但其应用的一个重要限制是荧光背景。由于拉曼信号和荧光信号同属光致发光现象,且光谱波长范围存在重叠,而荧光信号强度通常比拉曼信号强数个数量级,这使得荧光干扰问题尤为突出。时间门控拉曼光谱技术是区分微弱拉曼信号与强荧光背景的关键工具,但由于单光子雪崩二极管(SPAD)技术瓶颈,难以同时满足高光谱分辨率、宽光谱范围和高时间分辨率的需求。
    长春光机所李备团队与卡迪夫大学WolfgangLangbein团队报道称,将单光子时间计数与傅里叶变换结合,利用光子矩阵的方法,通过在庞大的光子事件中对数据进行重新排列,组成存储有光谱数据的二维矩阵。将光子强度与时间关系的二维矩阵经过高精度位移台的校正,转换为光子强度与光程差(位移台干涉距离)的矩阵。通过设计高精度的校正算法,能够在超长光程差的情况下实现高信噪比的拉曼光谱。
    实测结果表明,该系统可实现547 ps时间分辨率、-1000~10000 cm-1光谱范围、最大0.05cm-1的光谱分辨率,在拥有时间分辨率的同时,其他参数表现要优于现有商用拉曼系统2~4 cm-1,300~2000 cm-1光谱范围。团队设计了检验系统,证实了在时间尺度上拉曼信号的发生时刻要早于荧光信号。同时通过设置合适的时间门,该系统能够在复杂荧光背景环境下,滤除荧光信号,进而获取更加纯净的拉曼信号。
    该工作成功突破了传统时间门控拉曼光谱在光谱范围窄和分辨率低方面的核心限制,为生物细胞检测、微塑料分选、材料学表征等领域提供了新途径。
    (来源于中国科技期刊卓越行动计划入选期刊:《Light: Science&Applications》,2025,14,378)

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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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