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细胞抵御外来病原体的第一道防线是先天免疫反应。环状GMP-AMP合成酶（cGAS）在此过程中发挥关键作用，它能识别宿主细胞质中病原体来源的DNA或RNA，并启动信号级联反应，诱导Ⅰ型干扰素编码基因的转录。炎症加剧是衰老的一个典型特征，而衰老过程中cGAS信号的失调会引发导致机体功能衰退的炎症反应。因此，cGAS被视为潜在的治疗靶点。然而，尽管cGAS存在于细胞质中，但它主要与染色质结合，且其在细胞核内的功能尚不明确。Chen等在《Sci‐ence》报道称，裸鼹鼠的cGAS在其N端存在一组独特的4个突变，可促进DNA修复——这一机制对该物种的超长寿命至关重要。

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（图片来源：《Science》）

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