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中国科学院遗传与发育生物学研究所高彩霞团队与中国科学院微生物研究所邱金龙团队合作，对双生病毒复制子进行工程化改造，首次在植物底盘中构建了快速且通用的体内定向进化系统GRAPE，并利用该系统实现了植物免疫受体NRC3和Pikm-1的体内定向进化，为植物基因和蛋白的工程化改造提供了性能强大的高通量技术平台。2025年10月2日，相关研究成果发表于《Science》。

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（图片来源：《Science》）

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