Article(id=1208356304016491278, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1208356297246879939, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1766024193052, onlineDateStr=2025-12-18, pubDate=1756310400000, pubDateStr=2025-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1758297600000, onlineIssueDateStr=2025-09-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766024193052, creator=13701087609, updateTime=1774079862146, updator=sys-migrate, issue=Issue{id=1208356297246879939, tenantId=1146029695717560320, journalId=1146031591421210625, year='2025', volume='43', issue='16', pageStart='1', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1756310400000', pubDateStr='2025-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1766024191437, creator='13701087609', updateTime=1774330854827, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1243196968781070575, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1208356297246879939, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1243196968781070576, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1208356297246879939, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=8, endPage=8, ext={EN=ArticleExt(id=1208356304423338790, articleId=1208356304016491278, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=null, columnId=1157710593001177623, journalTitle=Science & Technology Review, columnName=Science and Technology News, runingTitle=null, highlight=null, articleAbstract=

做血检时，通常每测一种分子就要用一种酶；混在一起就“串台”。澳大利亚新南威尔士大学的团队把这个“不成文规定”改写了，他们设计出一支“会挑活儿”的纳米酶：在未经处理的全血里，只靠改变电极的电位脉冲顺序，就能先后选择性地检测葡萄糖与多巴胺2种截然不同的分子，而且都在同一滴样品里完成。核心做法是用金纳米核做活性中心，外面包一层惰性的碳壳，壳体里开出独立纳米通道，把底物像“分车道”一样引向活性位；再用电位把通道内的微环境（pH/离子/局部势场）调到最适合某一反应的状态，从而实现择一而反、按需切换。2025年8月22日，相关研究成果发表于《Chemical Science》。

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做血检时，通常每测一种分子就要用一种酶；混在一起就“串台”。澳大利亚新南威尔士大学的团队把这个“不成文规定”改写了，他们设计出一支“会挑活儿”的纳米酶：在未经处理的全血里，只靠改变电极的电位脉冲顺序，就能先后选择性地检测葡萄糖与多巴胺2种截然不同的分子，而且都在同一滴样品里完成。核心做法是用金纳米核做活性中心，外面包一层惰性的碳壳，壳体里开出独立纳米通道，把底物像“分车道”一样引向活性位；再用电位把通道内的微环境（pH/离子/局部势场）调到最适合某一反应的状态，从而实现择一而反、按需切换。2025年8月22日，相关研究成果发表于《Chemical Science》。

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（图片来源：《Chmical Science》）

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