Article(id=1207707603568796185, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, articleNumber=null, orderNo=6, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1765869530812, onlineDateStr=2025-12-16, pubDate=1753632000000, pubDateStr=2025-07-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1755532800000, onlineIssueDateStr=2025-08-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1765869530812, creator=13701087609, updateTime=1774079802466, updator=sys-migrate, issue=Issue{id=1207707597713547639, tenantId=1146029695717560320, journalId=1146031591421210625, year='2025', volume='43', issue='14', pageStart='1', pageEnd='104', issueExtLink='null', onlineDate='null', pubDate='1753632000000', pubDateStr='2025-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1765869529417, creator='13701087609', updateTime=1774330911654, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1243197207160144113, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1243197207160144114, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=9, endPage=10, ext={EN=ArticleExt(id=1207707603858203175, articleId=1207707603568796185, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=null, columnId=1157710593001177623, journalTitle=Science & Technology Review, columnName=Science and Technology News, runingTitle=null, highlight=null, articleAbstract=

为何人类等哺乳动物器官受损后无法通过再生自我修复？这是再生医学领域的重大科学难题之一。北京生命科学研究所、清华大学生物医学交叉研究院王伟团队在小鼠“耳朵”上找到了关键线索。耳廓大约在1.6亿年前随哺乳动物出现，并由皮肤、软骨与外周神经等多种组织共同构成。不同物种在耳廓受损后的修复能力迥异：家兔可形成芽基并最终实现完整再生，而小鼠则仅能形成瘢痕。两者细胞行为的显著差异为解析再生能力的分子基础提供了天然模型。团队首次发现维生素A的代谢产物视黄酸，可以调控哺乳动物的再生能力，并实现器官的完全再生。2025年6月26日，相关研究发表于《Science》。

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为何人类等哺乳动物器官受损后无法通过再生自我修复？这是再生医学领域的重大科学难题之一。北京生命科学研究所、清华大学生物医学交叉研究院王伟团队在小鼠“耳朵”上找到了关键线索。耳廓大约在1.6亿年前随哺乳动物出现，并由皮肤、软骨与外周神经等多种组织共同构成。不同物种在耳廓受损后的修复能力迥异：家兔可形成芽基并最终实现完整再生，而小鼠则仅能形成瘢痕。两者细胞行为的显著差异为解析再生能力的分子基础提供了天然模型。团队首次发现维生素A的代谢产物视黄酸，可以调控哺乳动物的再生能力，并实现器官的完全再生。2025年6月26日，相关研究发表于《Science》。

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（图片来源：《Science》）

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