Article(id=1207707603120005635, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, articleNumber=null, orderNo=5, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1765869530706, onlineDateStr=2025-12-16, pubDate=1753632000000, pubDateStr=2025-07-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1755532800000, onlineIssueDateStr=2025-08-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1765869530706, creator=13701087609, updateTime=1774079802576, updator=sys-migrate, issue=Issue{id=1207707597713547639, tenantId=1146029695717560320, journalId=1146031591421210625, year='2025', volume='43', issue='14', pageStart='1', pageEnd='104', issueExtLink='null', onlineDate='null', pubDate='1753632000000', pubDateStr='2025-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1765869529417, creator='13701087609', updateTime=1774330911654, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1243197207160144113, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1243197207160144114, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1207707597713547639, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4, endPage=9, ext={EN=ArticleExt(id=1207707603459744275, articleId=1207707603120005635, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=null, columnId=1157710593001177623, journalTitle=Science & Technology Review, columnName=Science and Technology News, runingTitle=null, highlight=null, articleAbstract=

细胞凋亡是生物体发育、组织稳态维持及免疫防御的关键机制，对维持健康至关重要。BCL-2蛋白家族通过精细调控线粒体凋亡通路，成为细胞生死决策的“开关”。在这个家族中，一个名为BAX的蛋白质扮演着至关重要的角色——堪称细胞内的“死神”。2025年6月26日，西湖大学校长、中国科学院院士施一公团队在《Science》上发表研究，解析了BAX不同类型聚合物共享的结构单元，解答了BAX究竟如何让细胞走上死亡的不归路。

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细胞凋亡是生物体发育、组织稳态维持及免疫防御的关键机制，对维持健康至关重要。BCL-2蛋白家族通过精细调控线粒体凋亡通路，成为细胞生死决策的“开关”。在这个家族中，一个名为BAX的蛋白质扮演着至关重要的角色——堪称细胞内的“死神”。2025年6月26日，西湖大学校长、中国科学院院士施一公团队在《Science》上发表研究，解析了BAX不同类型聚合物共享的结构单元，解答了BAX究竟如何让细胞走上死亡的不归路。

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（图片来源：《Science》）

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