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风湿免疫性疾病是继心血管病和癌症之后威胁人类健康的第3大杀手。2025年6月24日,海军军医大学徐沪济教授团队联合企业,在全球首创“现货型、低毒性、广谱靶向”的细胞治疗新产品(QN?139b),成功攻克被视为“不治之症”的系统性硬皮病(SSc),标志着自身免疫病精准治疗迈入新时代。该项成果发表在《Cell》。

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风湿免疫性疾病是继心血管病和癌症之后威胁人类健康的第3大杀手。2025年6月24日,海军军医大学徐沪济教授团队联合企业,在全球首创“现货型、低毒性、广谱靶向”的细胞治疗新产品(QN?139b),成功攻克被视为“不治之症”的系统性硬皮病(SSc),标志着自身免疫病精准治疗迈入新时代。该项成果发表在《Cell》。

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    风湿免疫性疾病是继心血管病和癌症之后威胁人类健康的第3大杀手。2025年6月24日,海军军医大学徐沪济教授团队联合企业,在全球首创“现货型、低毒性、广谱靶向”的细胞治疗新产品(QN?139b),成功攻克被视为“不治之症”的系统性硬皮病(SSc),标志着自身免疫病精准治疗迈入新时代。该项成果发表在《Cell》。

    风湿免疫性疾病是继心血管病和癌症之后威胁人类健康的第3大杀手。2025年6月24日,海军军医大学徐沪济教授团队联合企业,在全球首创“现货型、低毒性、广谱靶向”的细胞治疗新产品(QN?139b),成功攻克被视为“不治之症”的系统性硬皮病(SSc),标志着自身免疫病精准治疗迈入新时代。该项成果发表在《Cell》。

    . 通用性细胞疗法突破硬皮病难题. 科技导报, 2025 , 43 (14) : 11 -11 .
    . Science & Technology Review, 2025 , 43 (14) : 11 -11 .
    硬皮病是一种以免疫系统紊乱、广泛组织纤维化为特征的自身免疫性疾病,长期缺乏有效治疗手段。传统嵌合抗原受体T细胞免疫疗法(CAR-T)虽有精准杀伤异常免疫细胞的潜力,但因毒性大、成本高、依赖患者自体细胞,难以广泛应用。此次团队构建的新型嵌合抗原受体自然杀伤细胞免疫疗法(CAR-NK)细胞产品则以诱导多能干细胞(iPSC)为起点,结合多基因工程改造与双靶点设计,不仅解决了免疫排斥和安全性问题,还具备工业化批量生产能力。
    该疗法的核心在于用基因改造的NK细胞替代传统T细胞,赋予其CAR“导航系统”,精准清除病理性B细胞。研究显示,该CAR-NK细胞可同时靶向CD19和BCMA 2个免疫细胞标志物,几乎覆盖所有致病B细胞谱系,有效逆转硬皮病的免疫异常和纤维化过程。
    这种细胞还可预制为“通用型”产品,无需依赖患者细胞,治疗流程从过去的数月缩短为1 d内即可实施。在临床试验中,首位重症患者治疗后皮肤硬化大幅改善,肺功能提升超过25%,且无严重副作用发生。
    除了清除致病细胞,该疗法还具备“重编程免疫系统”和“修复受损组织”的双重功效。研究团队通过单细胞测序等技术发现,治疗后患者体内免疫平衡显著恢复,血管新生和组织修复同步发生,呈现出“功能性治愈”的趋势。
    相比传统CAR-T治疗动辄百万元的高昂成本,此项疗法预计可将费用降至20万元以内,真正实现安全、普惠、可复制的治疗路径。专家指出,这一技术不仅填补了CAR-NK在硬皮病治疗领域的空白,更为红斑狼疮、类风湿关节炎等多种自身免疫病的根本性治疗提供了新范式。
    (综合《Cell》、中国新闻网、澎湃新闻)

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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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