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马铃薯Y病毒(PVY)作为全球茄科作物的重要病原体,每年对马铃薯、辣椒和番茄等经济作物造成严重损失,其有效防治是当前农药化学领域的重要挑战。传统防治策略主要通过杀虫剂控制蚜虫媒介或施用抗病毒剂,但受限于虫体抗药性演变及药物作用靶标单一,实际防治效果始终难以突破。

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马铃薯Y病毒(PVY)作为全球茄科作物的重要病原体,每年对马铃薯、辣椒和番茄等经济作物造成严重损失,其有效防治是当前农药化学领域的重要挑战。传统防治策略主要通过杀虫剂控制蚜虫媒介或施用抗病毒剂,但受限于虫体抗药性演变及药物作用靶标单一,实际防治效果始终难以突破。

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(图片来源:《Research》)

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人工合成“分子剪刀”守护马铃薯健康
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马铃薯Y病毒(PVY)作为全球茄科作物的重要病原体,每年对马铃薯、辣椒和番茄等经济作物造成严重损失,其有效防治是当前农药化学领域的重要挑战。传统防治策略主要通过杀虫剂控制蚜虫媒介或施用抗病毒剂,但受限于虫体抗药性演变及药物作用靶标单一,实际防治效果始终难以突破。

马铃薯Y病毒(PVY)作为全球茄科作物的重要病原体,每年对马铃薯、辣椒和番茄等经济作物造成严重损失,其有效防治是当前农药化学领域的重要挑战。传统防治策略主要通过杀虫剂控制蚜虫媒介或施用抗病毒剂,但受限于虫体抗药性演变及药物作用靶标单一,实际防治效果始终难以突破。

. 人工合成“分子剪刀”守护马铃薯健康. 科技导报, 2025 , 43 (12) : 11 -11 .
. Science & Technology Review, 2025 , 43 (12) : 11 -11 .
马铃薯Y病毒(PVY)作为全球茄科作物的重要病原体,每年对马铃薯、辣椒和番茄等经济作物造成严重损失,其有效防治是当前农药化学领域的重要挑战。传统防治策略主要通过杀虫剂控制蚜虫媒介或施用抗病毒剂,但受限于虫体抗药性演变及药物作用靶标单一,实际防治效果始终难以突破。
贵州大学绿色农药全国重点实验室宋宝安和宋润江团队开发了一种全新的N-杂环卡宾催化体系,高效实现了对多种天然酚类物质的不对称苯酞官能化,具有优异的转化率和选择性。
通过对该方法合成的活性小分子开展生物活性测试,发现香芹酚的苯酞衍生物(R)-3w具有良好的抗PVY治疗活性,优于市场主流商品药利巴韦林和宁南霉素以及它的对映体和外消旋混合物。植物病毒编码的功能蛋白在介导病毒在寄主植物细胞内的增殖中发挥了重要作用。尽管PVY自身编码10~11种功能蛋白,但它们并非是直接翻译形成的。PVY的基因组首先会翻译形成一种大的多聚蛋白,它依赖Nuclear in‐ clusion A(简称Nia)蛋白酶将其剪切成一个个小的功能蛋白去行使致病行为。通过机制研究,团队发现(R)-3w可能正是作用于这把“剪刀”并钝化了它的“刀刃”,导致病毒功能蛋白生成效率显著降低,从而达到了抗病毒的效果。
该研究成果为PVY的有效化学防治贡献了全新的分子骨架、不对称合成方法和潜在的新靶标受体。
(来源于中国科技期刊卓越行动计划入选期刊:《Research》,2025,8(0637))

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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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