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中国疾病预防控制中心最新流行病学调查显示,中国成年人群非酒精性脂肪肝(NAFLD)患病率达29.2%,在北上广深等一线城市,35岁以下人群患病率年增长率超过7%。

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中国疾病预防控制中心最新流行病学调查显示,中国成年人群非酒精性脂肪肝(NAFLD)患病率达29.2%,在北上广深等一线城市,35岁以下人群患病率年增长率超过7%。

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    中国疾病预防控制中心最新流行病学调查显示,中国成年人群非酒精性脂肪肝(NAFLD)患病率达29.2%,在北上广深等一线城市,35岁以下人群患病率年增长率超过7%。

    中国疾病预防控制中心最新流行病学调查显示,中国成年人群非酒精性脂肪肝(NAFLD)患病率达29.2%,在北上广深等一线城市,35岁以下人群患病率年增长率超过7%。

    . 加剧成人脂肪肝生成的“元凶”被捕获. 科技导报, 2025 , 43 (12) : 5 -11 .
    . Science & Technology Review, 2025 , 43 (12) : 5 -11 .
    中国疾病预防控制中心最新流行病学调查显示,中国成年人群非酒精性脂肪肝(NAFLD)患病率达29.2%,在北上广深等一线城市,35岁以下人群患病率年增长率超过7%。
    干扰素调节因子家族(IRFs)因其独特的免疫调控功能,逐渐进入研究人员的视野。2025年5月,上海交通大学胡承与首都医科大学王亮合作,通过患者肝脏活检及多种脂肪肝小鼠模型,首次揭示了IRF8这一分子在脂肪肝进展中的关键角色。研究发现,NAFLD患者和实验动物的肝脏中IRF8的表达明显升高,而且脂肪摄入越多,IRF8就越活跃,进一步加剧肝脏脂质的积累。研究人员发现,IRF8能够直接激活生物钟关键基因BMAL1的表达,而BMAL1再打开了脂肪代谢的主控开关PPARγ,导致肝脏细胞大量吸收和合成脂肪酸。研究人员通过实验证实了这条信号通路的关键性。
    这项研究不仅补齐了脂质代谢调控网络中重要的一环,更指出IRF8-BMAL1-PPARγ轴是治疗NAFLD的潜在新靶点。研究团队表示,未来通过开发靶向这一信号通路的小分子药物,有望实现更有效的脂肪肝治疗策略,为全球庞大的NAFLD患者群体带来新的希望。
    (来源于中国科技期刊卓越行动计划入选期刊:《Genes & Diseases》,2025,12(3))

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    属数
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    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
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    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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