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人类大脑如何变得如此庞大和复杂一直是一个谜团。美国加州大学旧金山分校的Katherine Pollard团队发现,将一段仅存在于人类基因组中的遗传片段插入小鼠体内后,它们的大脑会长得比通常情况更大。2025年5月14日,相关研究成果发表于《Nature》。

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    人类大脑如何变得如此庞大和复杂一直是一个谜团。美国加州大学旧金山分校的Katherine Pollard团队发现,将一段仅存在于人类基因组中的遗传片段插入小鼠体内后,它们的大脑会长得比通常情况更大。2025年5月14日,相关研究成果发表于《Nature》。

    . 人类DNA使鼠脑变大. 科技导报, 2025 , 43 (11) : 6 -11 .
    . Science & Technology Review, 2025 , 43 (11) : 6 -11 .
    人类大脑如何变得如此庞大和复杂一直是一个谜团。美国加州大学旧金山分校的Katherine Pollard团队发现,将一段仅存在于人类基因组中的遗传片段插入小鼠体内后,它们的大脑会长得比通常情况更大。2025年5月14日,相关研究成果发表于《Nature》。
    先前的研究表明,“人类加速演化区”(HARs),即哺乳动物中普遍保守、但在人类从黑猩猩进化出来后迅速发生改变的短段基因组区域,可能是大脑发育和体积增大的关键因素之一,但这些HARs在大脑构建过程中的具体机制尚不清楚。
    为此,Pollard团队聚焦于他们在10年前发现的HARs——HARE5。在小鼠中,这段DNA已知可以增强Fzd8基因的表达,而Fzd8是神经细胞发育和生长的关键基因之一。研究人员比较了HARE5在小鼠、黑猩猩和人类中的作用效果。
    当研究人员用人类版本的HARE5替代活体小鼠自身版本的HARE5后,这些小鼠成年后的脑容量比未经过基因改造的小鼠平均大了6.5%。这种增强大脑的“助推器”在一种名为放射状胶质细胞的神经干细胞中最活跃,这些细胞最终会分化为神经元和其他脑细胞。人类版本的HARE5促进了这些胶质细胞的分裂和增殖,从而产生了比使用小鼠版本HARE5更多的神经元。
    研究人员还发现,含有黑猩猩版本HARE5的类器官所产生的放射状胶质细胞少于含有人类版本HARE5的类器官,而且这些胶质细胞的发育程度也较低。此外,HARE5增强了驱动神经干细胞生长的一个关键信号通路,进一步证实了这一遗传“助推器”在提高人类大脑体积和复杂性方面的作用。
    研究人员提醒,脑容量增大未必等同于认知提升;后续需通过行为学测试和多HARs组合编辑,评估功能、阈值与潜在副作用。不过,这项工作已为破解人脑演化之谜和精准治疗神经发育疾病奠定了可操作的试验模板。
    (综合《Nature》《中国科学报》、光明网)

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    2种不同金属材料的力学参数

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    属数
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    species
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    Percentage of
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    种数
    Number of
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    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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