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2024年，免疫治疗领域取得了一系列重要进展，为疾病治疗提供了新的思路和方法。综述了肿瘤免疫治疗的新策略、嵌合抗原受体T细胞疗法（chimeric antigen receptor T-cell immunotherapy, CAR-T）治疗自身免疫性疾病的突破，以及肿瘤浸润性淋巴细胞（tumor infiltrating lymphocytes，TIL）和CAR-T在实体癌症治疗中的应用进展。在肿瘤免疫治疗方面，研究发现靶向肿瘤微环境中的T细胞代谢，如乳酸代谢和氨代谢，能够显著增强抗肿瘤免疫效应，为提高治疗效果提供了新的方向。此外，CAR-T在治疗自身免疫性疾病中展现出巨大潜力，通过基因编辑和优化CAR结构，实现了对难治性疾病的治疗突破，为自身免疫性疾病的治疗提供了新的解决方案。在实体癌症治疗中，TIL和CAR-T的优化策略，如代谢调控和个性化设计，进一步提升了其抗肿瘤活性，为实体瘤治疗开辟了新的道路。建议未来研究应加强对免疫代谢机制的深入探索，并结合纳米技术等新兴手段，以提高治疗的精准性和有效性。综上所述，免疫治疗在不断取得新的突破，为未来疾病治疗提供了更多可能性和新思路，有望为患者带来更好的治疗效果和生活质量。

, authors=, authorsList=黄波, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=版权所有，未经授权，不得转载。, copyrightOwner=《科技导报》编辑部, extLink=null, articleAbsUrl=null, sourceXml=ThoXfoiK0Bi4YxYCfUIIHg==, magXml=ThoXfoiK0Bi4YxYCfUIIHg==, pdfUrl=null, pdf=m7+6HZKRJhuxgRADyoCMZA==, pdfFileSize=1545662, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=ZmFMpq8Dw8BkDEp4TWAE/A==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=K40aCzmayLCa0KCVozxkCA==, mapNumber=null, fund=null)}, authors=[Author(id=1242142099508900504, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1157774115357814908, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=tjhuangbo@hotmail.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1242142099592786586, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1157774115357814908, authorId=1242142099508900504, language=EN, stringName=Bo HUANG, firstName=Bo, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100730, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1242142099676672668, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1157774115357814908, authorId=1242142099508900504, language=CN, stringName=黄波, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院基础医学研究所, 北京 100730, bio={"content":"

黄波，教授，研究方向为肿瘤免疫，电子信箱: tjhuangbo@hotmail.com

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黄波，教授，研究方向为肿瘤免疫，电子信箱: tjhuangbo@hotmail.com

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