Article(id=1242141933406072850, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242141088937485147, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2024.07.00817, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719072000000, receivedDateStr=2024-06-23, revisedDate=1727280000000, revisedDateStr=2024-09-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1734105600000, onlineDateStr=2024-12-14, pubDate=1731427200000, pubDateStr=2024-11-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1734105600000, onlineIssueDateStr=2024-12-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079314802, creator=sys-migrate, updateTime=1774079314802, updator=sys-migrate, issue=Issue{id=1242141088937485147, tenantId=1146029695717560320, journalId=1146031591421210625, year='2024', volume='42', issue='21', pageStart='1', pageEnd='188', issueExtLink='null', onlineDate='null', pubDate='1731427200000', pubDateStr='2024-11-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774079113466, creator='sys-migrate', updateTime=1774079113466, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=73, endPage=86, ext={EN=ArticleExt(id=1242141942436406174, articleId=1242141933406072850, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Scientific problem finding research based on real world data, columnId=1242141098387252106, journalTitle=Science & Technology Review, columnName=Exclusive: The paradigm and application of clinical research in traditional Chinese medicine, runingTitle=null, highlight=null, articleAbstract=Scientific problem identification in real-world research is the cornerstone for conducting in-depth studies that result in high-quality real world evidence.This study, taking the descriptive statistical analysis of real-world actual diagnostic and treatment data of the persistent vegetative state (PVS) at the Vegetative Wake-up Promotion Centre of Xi'an Traditional Chinese Medicine Encephalopathy Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine as an example, comprehensively collected demographic information of PVS patients including Chinese and western medical doctors, their disease conditions, speciality examinations, laboratory examinations, scale examinations, information on Chinese medicine evidence and identification and type indicators and treatment indicators.The results found that the combination of Chinese and Western medicines such as acupuncture and moxibustion became one of the optional and effective treatments for PVS, but there were problems such as unclear treatment effects under complex interventions and inconsistency in the way evidence was classified.The analysis demonstrated the scientific problem discovery process of combining PVS clinical healthcare practice with the TCM clinical real world study.It also lays a foundation for further summarising the efficacy and diagnostic and treatment experience of Chinese medicine in promoting awakening of PVS, predicting the prognosis and likelihood of awakening of PVS patients, and improving the rate of promoting awakening of patients in persistent vegetative state., authors=LAI Keyun¹, CHEN Xiao², SONG Hujie², LAI Changsheng³, WANG Kaiyue², BAI Yang², ZHANG Ye², YI Wenhui², LIU Haiyang², RAN Jingchun², TAN Fuxiong², TIAN Yali², WANG Zhenguo², WANG Guangjun⁴, authorsList=LAI Keyun, CHEN Xiao, SONG Hujie, LAI Changsheng, WANG Kaiyue, BAI Yang, ZHANG Ye, YI Wenhui, LIU Haiyang, RAN Jingchun, TAN Fuxiong, TIAN Yali, WANG Zhenguo, WANG Guangjun, authorCompany=1. Department of Clinical Medicine of Traditional Chinese and Western Medicine, Shaanxi University of Chinese Medicine, Xianyang 710000, China;
2. Xi'an Traditional Chinese Medicine Encephalopathy Hospital, Xi'an 710032, China;
3. Yulin Red Cross Hospital, Yulin 537000, China;
4. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100070, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242141938569257880, articleId=1242141933406072850, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=基于真实世界数据的科学问题发现研究, columnId=1242141097774883713, journalTitle=科技导报, columnName=专题：中医临床研究的范式与应用, runingTitle=null, highlight=null, articleAbstract=以西安中医脑病医院植物人促醒中心持续植物状态（PVS）真实世界实际诊疗数据的描述性统计分析为例，全面收集PVS患者包括中西医在内的人口学资料、疾病情况、专科检查、实验室检查、量表检查、中医证候信息及辨证分型指标及治疗指标进行分析，结果发现，针灸等中西医结合的治疗方法成为PVS可选择且疗效显著的疗法之一，但在研究中也存在复杂干预下治疗效果不明确、证候分类方式不统一等问题。分析展示了PVS临床医疗实践与真实世界研究的中医临床科研范式结合的科学问题发现过程，以期在将来的真实世界研究中更好地实现临床科研一体化，达到从临床中来、到临床中去的目的，并为进一步总结中西医结合促醒PVS的疗效与诊治经验，预测PVS患者预后及苏醒可能性、提高持续植物状态患者的促醒率打下基础。, authors=赖科云¹, 陈霄², 宋虎杰², 赖昌生³, 王凯悦², 白杨², 张烨², 怡文辉², 刘海洋², 冉静纯², 谭福雄², 田亚丽², 王振国², 王广军⁴, authorsList=赖科云, 陈霄, 宋虎杰, 赖昌生, 王凯悦, 白杨, 张烨, 怡文辉, 刘海洋, 冉静纯, 谭福雄, 田亚丽, 王振国, 王广军, authorCompany=1. 陕西中医药大学中西医临床医学系, 咸阳 710000;
2. 西安中医脑病医院, 西安 710032;
3. 玉林市红十字会医院, 玉林 537000;
4. 中国中医科学院针灸研究所, 北京 100070, correspAuthors=null, authorNote=赖科云，硕士研究生，研究方向为中西医结合临床脑病，电子信箱：zyylky123@163.com；陈霄（通信作者），主任医师，研究方向为中西医结合临床脑病及植物状态促醒，电子信箱：chxxanb@126.com；宋虎杰（共同通信作者），主任医师，研究方向为中西医结合临床脑病，电子信箱：13909231298@139.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=teP4cq2jM2vrzFdOZvfW2w==, pdfFileSize=720441, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=陕西省中医药管理局科研项目（13-LC011）)}, authors=null, keywords=[Keyword(id=1242141936371445803, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=CN, orderNo=1, keyword=真实世界研究), Keyword(id=1242141937805894549, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=CN, orderNo=1, keyword=科学问题发现), Keyword(id=1242141937893974934, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=CN, orderNo=1, keyword=持续植物状态), Keyword(id=1242141937977861015, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=CN, orderNo=1, keyword=中西医结合治疗), Keyword(id=1242141938707669913, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=EN, orderNo=1, keyword=real world study), Keyword(id=1242141938791555994, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=EN, orderNo=1, keyword=scientific problem identification), Keyword(id=1242141940750295963, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=EN, orderNo=1, keyword=persistent vegetative state), Keyword(id=1242141942260245405, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141933406072850, language=EN, orderNo=1, keyword=combine traditional Chinese and western medicine)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1774230116083, createdBy=null, updatedBy=13041195026, firstLetterCn=S, firstLetterEn=S, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1242774439910290156, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1774230116107, updatedTime=1774230116107, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1242774439960621805, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1774230116119, updatedTime=1774230116119, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=S, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=null, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2024.07.00817, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2024.07.00817, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2024.07.00817, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2024.07.00817, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1731427200000, fullTextJson=null, articleText=null, reference=null)