Article(id=1242141892499022505, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242141088937485147, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2024.05.00465, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1718812800000, receivedDateStr=2024-06-20, revisedDate=1730908800000, revisedDateStr=2024-11-07, acceptedDate=null, acceptedDateStr=null, onlineDate=1734105600000, onlineDateStr=2024-12-14, pubDate=1731427200000, pubDateStr=2024-11-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1734105600000, onlineIssueDateStr=2024-12-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079305050, creator=sys-migrate, updateTime=1774079305050, updator=sys-migrate, issue=Issue{id=1242141088937485147, tenantId=1146029695717560320, journalId=1146031591421210625, year='2024', volume='42', issue='21', pageStart='1', pageEnd='188', issueExtLink='null', onlineDate='null', pubDate='1731427200000', pubDateStr='2024-11-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774079113466, creator='sys-migrate', updateTime=1774079113466, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=20, endPage=38, ext={EN=ArticleExt(id=1242141897888703166, articleId=1242141892499022505, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Construction of clinical practice guidelines for TCM intervention in coronary heart disease and analysis of real world evidence application status, columnId=1242141098387252106, journalTitle=Science & Technology Review, columnName=Exclusive: The paradigm and application of clinical research in traditional Chinese medicine, runingTitle=null, highlight=null, articleAbstract=In order to facilitate clinicians to make faster choices from many clinical guidelines, this paper evaluates the quality of clinical guidelines on Chinese medicine interventions for coronary heart disease using AGREE II and RIGHT reporting standards, and summarises their diagnostic and therapeutic opinions.It also assesses the role played by real world studies in the guidelines for TCM intervention in coronary heart disease and evaluates the quality of real world studies on TCM intervention in coronary heart disease.The results show that of the 10 guidelines included, 8 are evaluated as grade B and 2 as grade C.After summarizing the diagnostic and therapeutic opinions it is found that coronary heart disease is classified into different types of evidence in different guidelines, and the classification criteria have not yet been unified, among which the probabilities of cardioblood stasis and obstruction, qi and yin deficiency, cardio-kidney and yang deficiency, qi and blood stasis and qi and blood stasis are higher, and all of them are recommended in 5 or more guidelines.The recommended GRADE levels for herbal medicines are B, C and D.The former studies on which these guidelines were based were randomized controlled trials, systematic reviews, or expert consensus, and there were no real world studies as the source of evidence, and the evidence-based evidence of the characteristics of TCM was insufficiently reflected.Therefore, this study proposes the following recommendations for the development of guidelines on coronary heart disease in TCM.In the future, emphasis should be placed on constructing guideline evaluation tools that are consistent with the characteristics of TCM, standardising the process of guideline or consensus development, carrying out high-level, high-quality prospective studies, and considering controlling for the effects of bias, confounders, uncertainties, limitations and other influences on the quality of real world studies, in order to obtain high-quality real world research evidence with better quality, higher level of evidence, and more precise and reliable efficacy, focusing on the application of high-quality real world evidence, and also focusing on the promotion of its application, in order to better improve the clinical outcomes of patients with coronary heart disease, enhance clinical efficacy, and promote the long term development of Chinese medicine., authors=WANG Kewen¹, LUO Wenye¹, ZHANG Jing¹, HAO Xiuwei¹, KONG Dezhao^1,2, authorsList=WANG Kewen, LUO Wenye, ZHANG Jing, HAO Xiuwei, KONG Dezhao, authorCompany=1. The First Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China;
2. Peking University First Hospital, Beijing 100034, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242141895946740406, articleId=1242141892499022505, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=中医药干预冠心病临床实践指南构建与真实世界证据应用分析, columnId=1242141097774883713, journalTitle=科技导报, columnName=专题：中医临床研究的范式与应用, runingTitle=null, highlight=null, articleAbstract=运用AGREE II与RIGHT报告规范评价了中医药干预冠心病的临床指南质量，并对其诊疗意见进行汇总。评估了真实世界研究在中医药干预冠心病指南中发挥的作用，并对真实世界中医药干预冠心病研究的质量进行了评价。结果显示，纳入的10篇指南中，8篇评价为B级，2篇评价为C级。经过汇总诊疗意见发现，冠心病在不同指南中被分为不同证型，分类标准尚未统一，其中心血瘀阻证、气阴两虚证、气虚血瘀证、气滞血瘀证出现概率较高，均有5篇或5篇以上指南推荐。推荐的中药药物GRADE等级为B、C、D级。指南基于的原始研究分别为随机对照试验（randomized controlled trial,RCT）、系统综述、专家共识，无真实世界研究作为证据来源，中医药特色的循证证据体现不足。提出了中医药类冠心病指南的制订建议：未来在制订中医药类冠心病指南时，应着重构建符合中医药特性的指南评价工具、规范指南或共识的制定过程，开展高级别、高质量的前瞻性研究，考虑控制偏倚、混杂因素、不确定性、局限性等对真实世界研究质量的影响，以获得质量更好、证据级别更高、疗效更确切可靠的高质量真实世界研究证据；关注高质量的真实世界证据应用，同时着重推广，以更好地改善冠心病患者临床结局，提高临床疗效，推动中医药事业的长足发展。, authors=王科雯¹, 罗文晔¹, 张菁¹, 郝秀炜¹, 孔德昭^1,2, authorsList=王科雯, 罗文晔, 张菁, 郝秀炜, 孔德昭, authorCompany=1. 辽宁中医药大学第一临床学院, 沈阳 110000;
2. 北京大学第一医院, 北京 100034, correspAuthors=null, authorNote=王科雯，硕士研究生，研究方向为心血管系统疾病的防治，电子信箱：2928679474@qq.com；罗文晔（共同第一作者），硕士研究生，研究方向为心血管系统疾病的防治，电子信箱：1142270442@qq.com；孔德昭（通信作者），副主任医师，研究方向为中西医结合循证医学，中西医结合心血管疾病防治，电子信箱：dezhaok2007@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=yhda1G9essTuMM7SPZkt8g==, pdfFileSize=831878, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=中国博士后科学基金面上项目（2021M703618）；中华中医药学会青年人才托举工程项目（2022-QNRC2-B05）；国家重点基础研究发展计划项目（2013CB531704）；沈阳市科技局中青年科技创新人才计划项目（RC200104）；国家自然科学基金青年基金项目（81803978）；辽宁省科学技术厅博士科研启动基金计划项目（2021-BS-174）)}, authors=null, keywords=[Keyword(id=1242141895464399834, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141892499022505, language=CN, 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