Article(id=1242141932131001233, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242141088937485147, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2024.05.00463, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1716480000000, receivedDateStr=2024-05-24, revisedDate=1722787200000, revisedDateStr=2024-08-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1734105600000, onlineDateStr=2024-12-14, pubDate=1731427200000, pubDateStr=2024-11-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1734105600000, onlineIssueDateStr=2024-12-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079314498, creator=sys-migrate, updateTime=1774079314498, updator=sys-migrate, issue=Issue{id=1242141088937485147, tenantId=1146029695717560320, journalId=1146031591421210625, year='2024', volume='42', issue='21', pageStart='1', pageEnd='188', issueExtLink='null', onlineDate='null', pubDate='1731427200000', pubDateStr='2024-11-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774079113466, creator='sys-migrate', updateTime=1774079113466, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=47, endPage=54, ext={EN=ArticleExt(id=1242141935247372329, articleId=1242141932131001233, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Protective effect of Chinese medicine on progression of renal function in patients with chronic kidney disease stages 3-5, columnId=1242141098387252106, journalTitle=Science & Technology Review, columnName=Exclusive: The paradigm and application of clinical research in traditional Chinese medicine, runingTitle=null, highlight=null, articleAbstract=Based on the Clinical-Research-Disease Management Integration Platform of Jiangsu Hospital of Traditional Chinese Medicine, this article investigates the risk factors for the progression of patients with chronic kidney disease (CKD) stages 3-5 and the protective effects of traditional Chinese medicine (TCM).A total of 186 patients with CKD stages 3-5 attending the hospital from Mar 1, 2020 to Oct 30, 2023 were collected and grouped according to progression of their renal function, and the risk factors for the progression of the patients' renal function, as well as the effects of traditional Chinese medicine on their renal function, were assessed by logistic regression.Among 186 patients the average estimated glomerular filtration rate (eGFR) reduction rate was about 15.22% and the average eGFR slope was -3.44 mL·(min·1.73 m²）^-1 in the group with progressive renal function, and the average eGFR reduction rate was about 1.02% and the average eGFR slope was 1.33 mL·(min·1.73 m²）^-1 in the group with stable renal function.Logistic regression analysis using whether renal function progressed as the dependent variable and clinical indicators as independent variables showed that combined hypertension, uric acid >420 μmol·L^-1, and albumin <34 g·L^-1 were the risk factors for renal function progression in CKD patients, and age >65 years and taking TCM were the protective factors.Patients were grouped based on the duration of TCM usage.Survival analysis indicated that both the intermittent and continuous TCM usage groups had a higher rate of stable kidney function and higher eGFR compared to the group that did not use TCM.The results demonstrate that in CKD patients with concurrent hypertension, the higher uric acid levels and the lower albumin levels, the higher the risk of kidney function progression.TCM treatment and patients aged 65 and above tend to stabilize kidney function.Continuous and long-term intermittent use of TCM can delay the progression of kidney function deterioration in CKD patients and postpone the need for renal replacement therapy., authors=ZHU Peiqi¹, HE Jiayi², XIE Jiadong², ZHAO Jing¹, TANG Ruijie¹, SUN Wei¹, HE Weiming¹, authorsList=ZHU Peiqi, HE Jiayi, XIE Jiadong, ZHAO Jing, TANG Ruijie, SUN Wei, HE Weiming, authorCompany=1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China;
2. School of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, Nanjing 210023, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242141934723084324, articleId=1242141932131001233, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=中医药对慢性肾脏病3—5期患者肾功能进展的保护作用, columnId=1242141097774883713, journalTitle=科技导报, columnName=专题：中医临床研究的范式与应用, runingTitle=null, highlight=null, articleAbstract=基于江苏省中医院“临床-科研-慢病管理一体化平台”，探讨慢性肾脏病（chronic kid-ney disease，CKD）3—5期患者病情进展的危险因素及中医药的保护作用。收集了2020年3月1日至2023年10月30日，在江苏省中医院就诊的CKD 3—5期患者186例，根据患者肾功能进展情况分组，通过logistic回归，评估患者肾功能进展的危险因素，以及中药对肾功能的影响。结果表明，186例CKD 3—5期患者中，肾功能进展组平均估算的肾小球滤过率（eG-FR）降低率约为15.22%，平均eGFR斜率为-3.44 mL·（min·1.73 m²）^-1，肾功能平稳组平均eG-FR降低率约1.02%，平均eGFR斜率为1.33 mL·（min·1.73 m²）^-1。以肾功能是否进展为因变量，临床指标为自变量，logistic回归分析显示，合并高血压、尿酸>420 μmol·L^-1、白蛋白<34g·L^-1是CKD患者肾功能进展的危险因素，年龄>65岁、服用中药是保护因素。以服用中药时长进行分组，生存分析显示，间断及连续服用中药组比未服用中药组患者肾功能平稳率更高、eGFR更高。研究结果证明CKD患者并发高血压，且尿酸水平越高、白蛋白越低，肾功能进展的风险越高，服用中药治疗、年龄在65岁以上且越大的患者，肾功能趋于平稳。连续及长期间断服用中药能延缓CKD患者肾功能进展，延迟进入肾脏替代治疗。, authors=朱佩琦¹, 何佳怡², 谢佳东², 赵静¹, 唐睿婕¹, 孙伟¹, 何伟明¹, authorsList=朱佩琦, 何佳怡, 谢佳东, 赵静, 唐睿婕, 孙伟, 何伟明, authorCompany=1. 南京中医药大学附属医院, 南京 210029;
2. 南京中医药大学人工智能与信息技术学院, 南京 210023, correspAuthors=null, authorNote=朱佩琦，博士研究生，研究方向为中医药防治慢性肾脏病，电子信箱：Zhupeiqi0708@163.com；孙伟（通信作者），主任中医师，教授，研究方向为中医药防治慢性肾脏病，电子信箱：jssunwei@163.com；何伟明（共同通信作者），主任中医师，研究方向为中医药防治慢性肾脏病，电子信箱：yfy0019@njucm.edu.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=VMpMKBps7C7r50wiCQYsQA==, pdfFileSize=1214881, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划项目（2023YFC3502900）；江苏省中医药科技发展专项（k2020j14）)}, authors=null, keywords=[Keyword(id=1242141934341402654, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242141932131001233, language=CN, orderNo=1, keyword=慢性肾脏病3-5期), Keyword(id=1242141934408511520, tenantId=1146029695717560320, journalId=1146031591421210625, 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