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中药方剂中乳香类药物不良反应分析及临床对策
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科技导报 |专题:中医药传承与临床实践 2022 , 40 (23) : 91 -96
中药方剂中乳香类药物不良反应分析及临床对策
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王劲松1, 林飞2
作者信息
    1. 北京中医药大学附属护国寺中医医院, 北京 100035;
    2. 新乡医学院第一附属医院, 新乡 453100
通讯作者:
林飞(通信作者),副主任中医师,研究方向为中西医结合心血管疾病防治,电子信箱:linfeixixi@aliyun.com
作者简介:
王劲松,主管中药师,研究方向为中药临床药学及中药安全性,电子信箱: wjs15210152252@163.com
Analysis and clinical strategy on the adverse reactions of frankincense drugs in traditional Chinese medicine
  • WANG Jinsong1, LIN Fei2
  • Affiliations
      1. Huguosi Traditional Chinese Medicine Hospital Affiliated to Beijing University of Traditional Chinese Medicine, Beijing 100035, China;
      2. The First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, China
    出版时间: 2022-12-13 doi: 10.3981/j.issn.1000-7857.2022.23.012
    文章导航
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    乳香可舒筋行气,活血化瘀,是中医治疗痹症、湿阻病等多种疾病的常用药材,但乳香类药物存在诱发不良反应的风险。通过回顾性研究,将2022年1—6月于北京中医药大学附属护国寺中医医院开具含有乳香成分的中药处方作为研究对象,通过统计描述、相关性分析及多因素回归分析,旨在明确影响乳香不良反应的独立性因素。采用的指标包括处方中的乳香剂量、给药方式,患者的年龄、性别、过敏史以及记录不良反应类型等。结果共纳入108例处方,其中7例处方引发了不良反应,包括皮肤过敏6例、腹泻1例,多因素回归分析显示患者既往过敏史是影响乳香不良反应的唯一独立危险因素;说明现阶段中医临床实践使用的含有乳香的中药方剂所致的不良反应仅与既往过敏史有关,患者过敏史是合理用药、控制不良反应中需重点把握的环节。
    乳香类药物不良反应  /  皮肤过敏  /  过敏史
    Frankincense can relax sinew, promote flow of qi and blood circulation, and remove blood stasis. It is a commonly used medicinal material in traditional Chinese medicine for the treatment of arthralgia, dampness blocking disease and others. Frankincense drugs have the risk of inducing adverse reactions. This study used the traditional Chinese medicine prescriptions containing frankincense drugs in Huguosi traditional Chinese Medicine Hospital Affiliated to Beijing University of traditional Chinese Medicine from Jan to Mar 2022 as the research object. This retrospective study aimed to clarify the independent factors that affect the adverse reactions of frankincense through statistical description, correlation analysis and multivariate regression analysis. Indicators included dosage of frankincense in the prescription, mode of administration, as well as patient's age, gender, allergy history, adverse reactions, etc. Altogether 108 prescriptions were received, of which 7 prescriptions caused adverse reactions, including 6 skin allergies and 1 diarrhea. Multivariate regression analysis showed that the patient's allergy history was the only independent risk factor affecting the adverse reactions of frankincense drugs. It is shown that the adverse reactions of frankincense formula used in the clinical practice of traditional Chinese medicine at this stage are only related to the patient's allergy history, and which should be the focus of rational drug use and adverse reaction control.
    adverse reactions of frankincense drugs  /  skin allergy  /  allergic history
    王劲松, 林飞. 中药方剂中乳香类药物不良反应分析及临床对策. 科技导报, 2022 , 40 (23) : 91 -96 . DOI: 10.3981/j.issn.1000-7857.2022.23.012
    WANG Jinsong, LIN Fei. Analysis and clinical strategy on the adverse reactions of frankincense drugs in traditional Chinese medicine[J]. Science & Technology Review, 2022 , 40 (23) : 91 -96 . DOI: 10.3981/j.issn.1000-7857.2022.23.012

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    doi: 10.3981/j.issn.1000-7857.2022.23.012
    • 接收时间:2022-07-25
    • 首发时间:2022-12-12
    • 出版时间:2022-12-13
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    • 收稿日期:2022-07-25
    • 修回日期:2022-10-14
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    通讯作者:

    林飞(通信作者),副主任中医师,研究方向为中西医结合心血管疾病防治,电子信箱:linfeixixi@aliyun.com
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    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
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