Article(id=1242139950368502276, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139943573729769, articleNumber=null, orderNo=7, doi=10.3981/j.issn.1000-7857.2022.13.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1619366400000, receivedDateStr=2021-04-26, revisedDate=1636041600000, revisedDateStr=2021-11-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1662112959303, onlineDateStr=2022-09-02, pubDate=1657641600000, pubDateStr=2022-07-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1662112959303, onlineIssueDateStr=2022-09-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078842009, creator=sys-migrate, updateTime=1774078842009, updator=sys-migrate, issue=Issue{id=1242139943573729769, tenantId=1146029695717560320, journalId=1146031591421210625, year='2022', volume='40', issue='13', pageStart='0', pageEnd='120', issueExtLink='null', onlineDate='null', pubDate='1657641600000', pubDateStr='2022-07-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078840389, creator='sys-migrate', updateTime=1774078840389, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=50, endPage=56, ext={EN=ArticleExt(id=1242139954348892329, articleId=1242139950368502276, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Development status of ssDNA-GFET nano-biosensors toward wearable or implantable clinical applications, columnId=1242139948040659064, journalTitle=Science & Technology Review, columnName=Exclusive: Intelligent Manufacture, runingTitle=null, highlight=null, articleAbstract=Single strand DNA probe-graphene field effect transistor (ssDNA-GFET) nano-biosensor holds great potential in wearable or implantable clinic applications. This paper reviews the development status of ssDNA-GFET, methods on optimizing biomarker sensing performance, detection of biomarkers in human biofluids, and the development status of flexible ssDNA-GFET toward wearable or implantable clinic applications. In the end, the paper demonstrates current limitations of the sensor that hampers its real clinic applications., authors=HAO Zhuang^1,2, LIU Shaoqin², PAN Yunlu¹, authorsList=HAO Zhuang, LIU Shaoqin, PAN Yunlu, authorCompany=1. School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150000, China;
2. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150000, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=aN7ywnGDagKDwuETH9THrw==, pdfFileSize=2884574, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242139952943800479, articleId=1242139950368502276, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=面向穿戴或植入式临床应用的ssDNA-GFET纳米生物传感器发展现状, columnId=1242137176117420264, journalTitle=科技导报, columnName=专题：智能制造, runingTitle=null, highlight=null, articleAbstract=单链DNA探针-石墨烯场效应管（ssDNA-GFET）纳米生物传感器在可穿戴或可植入式临床应用领域有着广泛前景。介绍了现有ssDNA-GFET的应用、标志物检测性能提升方法、真实人体样本溶液中标志物检测，以及面向可穿戴或可植入式临床应用的柔性化研发现状，总结了ssDNA-GFET在投入实际可穿戴或可植入式临床应用前有待解决的问题。, authors=郝壮^1,2, 刘绍琴², 潘昀路¹, authorsList=郝壮, 刘绍琴, 潘昀路, authorCompany=1. 哈尔滨工业大学机电工程学院, 哈尔滨 150000;
2. 哈尔滨工业大学化工与化学学院, 哈尔滨 150000, correspAuthors=null, authorNote=郝壮,讲师,研究方向为基于低维材料的柔性可穿戴或可植入式电子器件,电子信箱:haozhuang@hit.edu.cn, correspAuthorsNote=潘昀路(通信作者),教授,研究方向为基于低维材料的柔性可穿戴或可植入式电子器件,电子信箱:yunlupan@hit.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=gy89c95FFEL0PvVc2rDpAA==, pdfFileSize=2884574, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目(52005137))}, authors=null, keywords=[Keyword(id=1242139952465649817, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=CN, orderNo=1, keyword=单链 DNA探针), Keyword(id=1242139952536952986, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=CN, orderNo=1, keyword=石墨烯), Keyword(id=1242139952620839068, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=CN, orderNo=1, keyword=场效应管), Keyword(id=1242139952700530845, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=CN, orderNo=1, keyword=生物传感器), Keyword(id=1242139952788611230, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=CN, orderNo=1, keyword=柔性电子), Keyword(id=1242139953870741668, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=EN, orderNo=1, keyword=single strand DNA probe), Keyword(id=1242139953950433445, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=EN, orderNo=1, keyword=graphene), Keyword(id=1242139954030125222, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=EN, orderNo=1, keyword=FET), Keyword(id=1242139954114011303, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=EN, orderNo=1, keyword=biosensor), Keyword(id=1242139954206285992, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139950368502276, language=EN, orderNo=1, keyword=flexible electronics)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1774230116083, createdBy=null, updatedBy=13041195026, firstLetterCn=S, firstLetterEn=S, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1242774439910290156, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1774230116107, updatedTime=1774230116107, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1242774439960621805, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1774230116119, updatedTime=1774230116119, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=S, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=null, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2022.13.005, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2022.13.005, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2022.13.005, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2022.13.005, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1657641600000, fullTextJson=null, articleText=null, reference=null)