Article(id=1242138776403780241, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242138750193578878, articleNumber=null, orderNo=21, doi=10.3981/j.issn.1000-7857.2020.22.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1573747200000, receivedDateStr=2019-11-15, revisedDate=1589126400000, revisedDateStr=2020-05-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1610588808873, onlineDateStr=2021-01-14, pubDate=1606492800000, pubDateStr=2020-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1610588808873, onlineIssueDateStr=2021-01-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078562114, creator=sys-migrate, updateTime=1774078562114, updator=sys-migrate, issue=Issue{id=1242138750193578878, tenantId=1146029695717560320, journalId=1146031591421210625, year='2020', volume='38', issue='22', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1606492800000', pubDateStr='2020-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078555865, creator='sys-migrate', updateTime=1774078555865, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=114, endPage=122, ext={EN=ArticleExt(id=1242138779838915249, articleId=1242138776403780241, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=The mechanical responses of cell to electrical stimulation, columnId=1242137755002675584, journalTitle=Science & Technology Review, columnName=Review, runingTitle=null, highlight=null, articleAbstract=In the past 40 years, the electrical stimulation is widely applied in biomedicine, largely due to the progress achieved in the experimental studies of electrical stimulation of cells. The obtained results are valuable for developing novel diagnosis and therapy techniques for diseases. Recent studies focused on the mechanism by which electrical stimulation alters cellular biological behavior, but the interpretation of many of related phenomena is difficult and controversial. We discuss the experimental equipment for electrical stimulation of cells from three aspects:the direct current electric field, the sinusoidal electric field and the pulsed electric field, and the effects of electrical stimulation on the mechanical properties of cells, including the elasticity modulus, the intercellular stress, the cell adhesion and the cell membrane tether force, as well as the corresponding biological mechanism and the application of electrical stimulation in inducing the cell differentiation, the apoptosis and changing the cell migration direction. The correlations among the electrical stimulation, the mechanical characteristics of cells and the biological behavior of cells are analyzed. Finally, we highlight the existing problems in the electrical stimulation of cells and put forward some suggestions for the future development., authors=SUN Weihao¹, MA Jianli¹, LIU Hailong², WU Chengwei¹, ZHANG Wei¹, PENGPAT Kamonpan³, authorsList=SUN Weihao, MA Jianli, LIU Hailong, WU Chengwei, ZHANG Wei, PENGPAT Kamonpan, authorCompany=1. Department of Engineering Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116024, China;
2. Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, China;
3. Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50202, Thailand, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Kp+Tals8Il7uMotAx6Pqqg==, pdfFileSize=728290, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242138778052146172, articleId=1242138776403780241, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=细胞力学特性对电刺激的响应研究进展, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=近40年，探索电刺激在生物医学中的应用引起了人们极大的兴趣，这种兴趣很大程度上来自于电刺激细胞实验研究方面取得的进展，其结果对研发疾病诊疗新技术具有参考意义。从直流电场、正弦电场、脉冲电场3个方面回顾电刺激细胞的实验设备，综述了电刺激对细胞弹性模量、细胞间应力、细胞黏附力、细胞膜系索力等力学特性的影响规律与生物学机理，以及电刺激在诱导细胞分化，凋亡，改变细胞迁移方向等方面的应用。总结了电刺激-细胞力学特性-细胞生物行为关联性研究的进展。直流电场可引导细胞迁移和排列；正弦电场可导致细胞膜和骨架的分离；脉冲电场可破坏细胞膜、细胞骨架、核膜、染色体端粒的结构，使细胞变形。探讨了目前细胞电刺激研究存在的问题，并对未来发展方向提出了建议。, authors=孙伟皓¹, 马建立¹, 刘海龙², 吴承伟¹, 张伟¹, Kamonpan Pengpat³, authorsList=孙伟皓, 马建立, 刘海龙, 吴承伟, 张伟, Kamonpan Pengpat, authorCompany=1. 大连理工大学工程力学系, 工业装备结构分析国家重点实验室, 大连 116024;
2. 大连理工大学生物医学工程学院, 大连 116024;
3. 清迈大学理学院物理与材料科学系, 泰国清迈 50202, correspAuthors=null, authorNote=孙伟皓,硕士研究生,研究方向为电刺激对细胞力学性能的调控机理与应用,电子信箱:17865191886@163.com, correspAuthorsNote=张伟(通信作者),教授,博士生导师,研究方向为磁感应热疗恶性肿瘤技术和生物医用水凝胶研发,电子信箱:wei.zhang@dlut.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=zVQL0tmuF4/pAucg0iHR1g==, pdfFileSize=728290, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划项目（2018YFA0704103，2018YFA0704104），辽宁省自然科学基金项目（2019-KF-02-01），中央高校基本科研业务费项目（DUT18ZD302）)}, authors=null, keywords=[Keyword(id=1242138777649488532, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242138776403780241, language=CN, orderNo=1, keyword=电刺激), Keyword(id=1242138777729184761, tenantId=1146029695717560320, journalId=1146031591421210625, 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