Article(id=1242137216558903501, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242137208371622071, articleNumber=null, orderNo=8, doi=10.3981/j.issn.1000-7857.2018.22.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1532880000000, receivedDateStr=2018-07-30, revisedDate=1537804800000, revisedDateStr=2018-09-25, acceptedDate=null, acceptedDateStr=null, onlineDate=1544768629457, onlineDateStr=2018-12-14, pubDate=1543334400000, pubDateStr=2018-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1544768629457, onlineIssueDateStr=2018-12-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078190214, creator=sys-migrate, updateTime=1774078190214, updator=sys-migrate, issue=Issue{id=1242137208371622071, tenantId=1146029695717560320, journalId=1146031591421210625, year='2018', volume='36', issue='22', pageStart='1', pageEnd='160', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078188263, creator=sys-migrate, updateTime=1774078188263, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=74, endPage=86, ext={EN=ArticleExt(id=1242137220497354993, articleId=1242137216558903501, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Recent progress of in vitro diagnostic technology based on nanomaterials, columnId=1242137214231064779, journalTitle=Science & Technology Review, columnName=Exclusive: Nanobiomedicine, runingTitle=null, highlight=null, articleAbstract=Due to their unique optical, magnetic, electrical, and thermal properties, nanomaterials can be utilized to generate different types of detection signals, amplify the intensity of detection signal, and simplify diagnostic procedure, indicating their great potential in the development of various nanomaterials based in vitro diagnostic technologies. In this review, we first introduce unique properties of typical nanomaterials of quantum dots, gold nanoparticles and iron oxide nanoparticles commonly used in in vitro diagnostic applications, and then discuss the current advances of diagnostic systems by utilizing their optical, magnetic, electrical, and thermal properties for the detection of nucleic acids, proteins, small molecules, bacteria and viruses. Finally, we summarize the challenges of large-scale synthesis and surface modification of the nanoparticles, automatic detection and clinical evaluation. We hope this review will help drive the development of nanomaterials based in vitro diagnostic technology and its related fields., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=AzI4LNf/k2y7LEx3O5c6Iw==, pdfFileSize=3494345, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=School of Materials Science and Engineering, Shanghai Jiao Tong University;State Key Lab of Metal Matrix Composites, Shanghai 200240, China, fund=null, authors=LI Wanwan, SHEN Mengfei, LIU Xinyi, authorsList=LI Wanwan, SHEN Mengfei, LIU Xinyi), CN=ArticleExt(id=1242137218664444122, articleId=1242137216558903501, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=纳米材料在体外诊断技术中的应用研究进展, columnId=1242137213048271044, journalTitle=科技导报, columnName=专题：纳米生物医学, runingTitle=null, highlight=null, articleAbstract=由于纳米材料具有独特的光、磁、电、热性能，可用于产生不同类型的检测信号、放大检测信号的强度及简化检测过程等，因此基于纳米材料的体外诊断技术具有广阔的应用前景。介绍了半导体量子点、金纳米颗粒和磁性氧化铁纳米颗粒等典型纳米材料的性能特点，综述了近年来将具有优异光学性能的半导体量子点、电性能和热性能的金纳米颗粒和超顺磁性的氧化铁纳米颗粒等纳米材料应用于检测核酸、蛋白、小分子、细菌和病毒等的研究进展，并对其未来的发展涉及的纳米材料的宏量制备及修饰、自动化检测及临床评价等方面做了简单评述，以助力纳米体外诊断技术的发展。, correspAuthors=null, authorNote=李万万,研究员,研究方向为功能微纳米材料及其应用,电子信箱:wwli@sjtu.edu.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=CHTlYr8eAXybaRItAZJP2A==, pdfFileSize=3494345, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=上海交通大学材料科学与工程学院, 金属基复合材料国家重点实验室, 上海 200240, fund=国家自然科学基金项目（81671782）；国家重点研发计划项目（2017YFA0205304）；上海申康医院发展中心临床创新3年行动计划项目（16CR3057A）；上海交通大学医工交叉研究基金项目（YG2017ZD02）, authors=李万万, 沈梦飞, 刘心怡, authorsList=李万万, 沈梦飞, 刘心怡)}, authors=null, keywords=[Keyword(id=1242137218391814355, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137216558903501, language=CN, orderNo=1, keyword=纳米材料), Keyword(id=1242137218458923221, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137216558903501, language=CN, orderNo=1, keyword=光、磁、电、热性能), Keyword(id=1242137218538614999, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137216558903501, language=CN, orderNo=1, keyword=体外诊断), Keyword(id=1242137219310366947, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137216558903501, language=EN, orderNo=1, keyword=nanomaterials), Keyword(id=1242137219402637686, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137216558903501, language=EN, 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