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2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China, fund=null, authors=BAI Yibing¹, XU Chenqi^1,2, authorsList=BAI Yibing, XU Chenqi), CN=ArticleExt(id=1242136788194631823, articleId=1242136786495938693, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=基于胆固醇代谢调控的肿瘤免疫治疗新方法, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=免疫检测点阻断疗法等肿瘤免疫疗法近年在临床上取得了重大突破，但仍存在响应率低等显著缺点，需开发新的肿瘤免疫疗法以使更多肿瘤患者受益。胆固醇作为细胞质膜脂质的重要组成成分，其代谢可以影响T细胞的质膜环境及效应功能。本研究发现，通过调控胆固醇代谢可以增强CD8⁺ T细胞的抗肿瘤免疫反应。抑制关键胆固醇酯化酶ACAT1的活性，CD8⁺ T细胞质膜游离胆固醇水平上调，细胞的抗肿瘤免疫应答显著增强，这为肿瘤免疫治疗提供了新思路和新方法。, correspAuthors=null, authorNote=白轶冰,博士研究生,研究方向为T细胞抗肿瘤免疫及胆固醇代谢,电子信箱:ybbai@sibcb.ac.cn, correspAuthorsNote=许琛琦(通信作者),研究员,研究方向为淋巴细胞与疾病,电子信箱:cqxu@sibcb.ac.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=j1TfhwpHevH3f8vKg9SgOg==, pdfFileSize=702997, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 中国科学院生物化学与细胞生物学研究所, 上海 200031;
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