Article(id=1242136593197244802, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242136577695097200, articleNumber=null, orderNo=11, doi=10.3981/j.issn.1000-7857.2017.24.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1507564800000, receivedDateStr=2017-10-10, revisedDate=1511712000000, revisedDateStr=2017-11-27, acceptedDate=null, acceptedDateStr=null, onlineDate=1514529964790, onlineDateStr=2017-12-29, pubDate=1514390400000, pubDateStr=2017-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1514529964790, onlineIssueDateStr=2017-12-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078041596, creator=sys-migrate, updateTime=1774078041596, updator=sys-migrate, issue=Issue{id=1242136577695097200, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='24', pageStart='1', pageEnd='97', issueExtLink='null', onlineDate='null', pubDate='1514390400000', pubDateStr='2017-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078037899, creator='sys-migrate', updateTime=1774078037899, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=40, endPage=47, ext={EN=ArticleExt(id=1242136597248942491, articleId=1242136593197244802, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Technology progress of alternative to animal testing, columnId=1242133161577095994, journalTitle=Science & Technology Review, columnName=Special Issues, runingTitle=null, highlight=null, articleAbstract=This paper reviews the technological progresss and the regulatory acceptance of alternative methods, including the development of the concept of alternative to the animal test, which can be divided into three phases as the starting accumulation, the regulation acceptance and the accelerated development.. The focus is on the theories of the Toxicity Testing in the Twenty-First Century (TT21C), the Adverse Outcome Pathway(AOP) and the integrated testing strategy, The new technologies include the reconstructed tissues and the multiorgans-on-chip, the stem cells, the " omics-"technology, and the non-testing approaches, and the high throughput and the high content screening are integrated into the alternative methods, with obvious interdisciplinary features. The standardized alternative methods and the personalized in vitro methods are applied in the assessment of health related products of chemicals,cosmetics,medicals and other biological products. It is concluded that the technology of the alternative to the animal testing is not only an important part of lab animal science, but also an innovative tool for scientific progress and with the prospect of industrialization., authors=CHENG Shujun, authorsList=CHENG Shujun, authorCompany=Guagdong Inspection and Quarantine Technology Center, Guangzhou 510623, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=kH7Fn2SlyKOY0ynp7F+r1w==, pdfFileSize=652955, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242136595055325572, articleId=1242136593197244802, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=动物实验替代技术研究进展, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=综述了动物实验替代技术的发展及法规接受情况。介绍了替代动物实验的历史，阐述了在21世纪毒性测试新观念（TT21C）、有害结局通路（AOP）、整合测试等理论的指导下，组织重建和多器官人体芯片技术、干细胞技术、组学技术、非生物测试技术、高通量和高内涵技术等新技术对动物实验替代方法的促进分析了标准化的替代方法和个性化的体外方法在化学品、化妆品、药品和生物制品等健康相关产品评估中的应用。分析表明，替代技术不仅是实验动物学科的重要分支，也是一类研发和实验用的创新性工具，同时具有产业化的前景。, authors=程树军, authorsList=程树军, authorCompany=广东出入境检验检疫局技术中心, 广州 510623, correspAuthors=null, authorNote=程树军,研究员,研究方向为动物实验替代方法研发及标准化,电子信箱:chengsj@126.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=L2h8yP4mpE+4O0qZFer/Xw==, pdfFileSize=652955, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=广东省科技计划项目（2015A030402005）)}, 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