Article(id=1242136417095201618, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242136396396311300, articleNumber=null, orderNo=17, doi=10.3981/j.issn.1000-7857.2017.19.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1490025600000, receivedDateStr=2017-03-21, revisedDate=1494777600000, revisedDateStr=2017-05-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1508290463357, onlineDateStr=2017-10-18, pubDate=1507824000000, pubDateStr=2017-10-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1508290463357, onlineIssueDateStr=2017-10-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077999609, creator=sys-migrate, updateTime=1774077999609, updator=sys-migrate, issue=Issue{id=1242136396396311300, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='19', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1507824000000', pubDateStr='2017-10-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077994675, creator='sys-migrate', updateTime=1774077994675, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=74, endPage=80, ext={EN=ArticleExt(id=1242136420538721126, articleId=1242136417095201618, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Researches on the gene clusters of amphotericin B and its combinatorial biology, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Amphotericin B, as the first drug against deep fungal infection which has been used for more than fifty years, is still an indispensable antibiotic in clinical treatment. In recent years, with the development of AmB derivatives, the analysis of genome of the Streptomyces nodosus and the metabolic pathways of AmB, more and more strategies involving genetic engineering and metabolic engineering were used to study the combinatorial biosynthesis of AmB. It's obviously AmB paly an important role in clinical treatment, for this reason developing the production of AmB has significant economic and social benefits. Herein, a brief summary of AmB, the organization of the AmBiosynthetic gene cluster and its current combinatorial biosynthesis is reviewed., authors=ZHANG Bo, ZHANG Haidong, ZHOU Yiteng, HUANG Kai, LIU Zhiqiang, authorsList=ZHANG Bo, ZHANG Haidong, ZHOU Yiteng, HUANG Kai, LIU Zhiqiang, authorCompany=Key Laboratory of Bioorganic Synthesis of Zhejiang Province;College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=HrqMDmpNjgPb9qJVm/gqjA==, pdfFileSize=1210292, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242136419611784040, articleId=1242136417095201618, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=两性霉素B合成基因簇及其组合生物学进展, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=两性霉素B（AmB）作为第一个用于深部真菌感染的药物，自上市以来已使用超过半个世纪，目前仍是临床治疗中不可缺少的药物。随着近年来AmB衍生物药物的发展，以及其生产菌株结节链霉菌（Streptomyces nodosus）全基因组和AmB体内合成代谢途径的解析，运用基因工程和代谢工程的方法对AmB组合生物合成的研究逐渐增多。由于AmB在当今临床治疗上的地位仍极其重要，因此促进AmB产业的发展具有显著的经济及社会效益。本文对AmB进行了概述，并对其合成基因簇相关基因及其当前组合生物合成的研究现况进行了总结与探讨。, authors=张博, 张海东, 周奕腾, 黄恺, 柳志强, authorsList=张博, 张海东, 周奕腾, 黄恺, 柳志强, authorCompany=浙江工业大学生物工程学院;浙江省生物有机合成技术研究重点实验室, 杭州 310014, correspAuthors=null, authorNote=张博,讲师,研究方向为代谢工程及合成生物学,电子信箱:zhangbo0305@zjut.edu.cn, correspAuthorsNote=柳志强(通信作者),教授,研究方向为工业催化及酶定向改造,电子信箱:microliu@zjut.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=9gzTUvMKz1pvAhCcbdf1Sw==, pdfFileSize=1210292, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=浙江省教育厅科学研究项目（Y201636181）；中国博士后科学基金（2016M601962）)}, authors=null, keywords=[Keyword(id=1242136419221713759, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136417095201618, language=CN, orderNo=1, keyword=两性霉素B), Keyword(id=1242136419293016928, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136417095201618, language=CN, orderNo=1, keyword=结节链霉菌), Keyword(id=1242136419393680227, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136417095201618, language=CN, orderNo=1, keyword=合成基因簇), Keyword(id=1242136419469177701, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136417095201618, language=CN, orderNo=1, keyword=组合生物学), Keyword(id=1242136420165428065, tenantId=1146029695717560320, 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