Article(id=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242136040736109467, articleNumber=null, orderNo=13, doi=10.3981/j.issn.1000-7857.2017.10.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1456934400000, receivedDateStr=2016-03-03, revisedDate=1481558400000, revisedDateStr=2016-12-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1495691321933, onlineDateStr=2017-05-25, pubDate=1495900800000, pubDateStr=2017-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1495691321933, onlineIssueDateStr=2017-05-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077914277, creator=sys-migrate, updateTime=1774077914277, updator=sys-migrate, issue=Issue{id=1242136040736109467, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='10', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='1495900800000', pubDateStr='2017-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077909878, creator='sys-migrate', updateTime=1774077909878, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=64, endPage=70, ext={EN=ArticleExt(id=1242136063695729633, articleId=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Protective effect of dietary 5'-nucleotides on alcohol-induced kidney injury of mice, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=This paper investigates the protective effects of dietary 5'-nucleotides on alcohol-induced kidney injury of mice. A total of 35 specific pathogen free (SPF) male Wistar mice are randomly divided into 5 groups given alcohol, equivalent distilled water or an isocaloric amount of dextrose intragastrically for 8 weeks. The two groups of alcohol-induced rats are fed with AIN-93G rodent diets including 0.04% and 0.16% 5'-nucleotides, respectively. Body weight (bw), renal function indexes and serum concentration of ICAM-1 and PCM-1 are measured, and renal pathologic changes stained by hematoxylin and eosin stain are observed by election microscope. The result shows that dietary 5'-nucleotides can reduce the rise of urinary protein per 24 h and level of blood serum creatinine (SCr) induced by alcohol, as well as the blood urea nitrogen (BUN) in the 0.16% NTs group. And compared to the alcohol group, the endogenous creatinine clearance are decreased significantly in the 0.04% and 0.16% NTs groups. The renal lesions present glomerular mesangium proliferation, inflammatory cell infiltration in tubule-interstitial and vacuolation or swell of renal tubule epithelium in the alcohol group, which are less in both NTs groups. The serum concentrations of ICAM-1 and PCM-1 of NTs groups are also lower than those of the alcohol group. What's more, the expression changes of PCX-1, TGF-β and fibronectin (FN) in kidney induced by alcohol are repaired by NTs supplement. In conclusion, the dietary 5'-nucleotides can protect kidney from injury induced by alcohol in mice., authors=WANG Nan, CAI Xiaxia, BAO Lei, LIU Rui, REN Jinwei, XU Meihong, LI Yong, authorsList=WANG Nan, CAI Xiaxia, BAO Lei, LIU Rui, REN Jinwei, XU Meihong, LI Yong, authorCompany=Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing 100191, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=egE/GTudlt+gFheZKvxodA==, pdfFileSize=5530785, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242136062252884970, articleId=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=膳食5'-核苷酸对大鼠酒精性肾损伤保护作用的研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为研究膳食5'-核苷酸对大鼠酒精性肾损伤的保护作用，选取35只SPF级雄性Wistar大鼠，随机分成5组：普通对照组、酒精组、葡萄糖等热量组、酒精+0.04%核苷酸干预组、酒精+0.16%核苷酸干预组。连续灌胃8周后，测定体重、肾体比、血肌酐（SCr）、尿肌酐（UCr）、血尿素氮（BUN）及24 h尿蛋白等相关指标；计算内生肌酐清除率（Ccr）；检测血清炎症因子细胞间黏附分子-1（ICAM-1）、单核细胞趋化因子-1（MCP-1）水平；HE染色观察肾脏组织病理学改变；免疫组化法观察肾脏足细胞标志蛋白PCX-1、肾间质转化生长因子-β（TGF-β）和纤连蛋白（FN）的表达。结果表明：膳食5'-核苷酸能够降低酒精引起的大鼠24 h尿蛋白、血肌酐升高并提高内生肌酐清除率（P<0.05），0.16%核苷酸干预组还能显著降低酒精引起的大鼠血尿素氮升高（P<0.05）；减轻酒精导致的肾脏组织结构病理改变及血清炎症因子ICAM-1、MCP-1水平的升高（P<0.05）；同时减轻甚至逆转酒精导致的肾脏PCX-1、TGF-β和FN表达的改变。由此可知，膳食5'-核苷酸可以通过减轻血液炎症反应，调节肾脏蛋白质分子的表达，对酒精造成的大鼠肾损伤产生一定的保护作用。, authors=王楠, 蔡夏夏, 鲍雷, 刘睿, 任金威, 徐美虹, 李勇, authorsList=王楠, 蔡夏夏, 鲍雷, 刘睿, 任金威, 徐美虹, 李勇, authorCompany=北京大学医学部公共卫生学院营养与食品卫生学系, 北京 100191, correspAuthors=null, authorNote=王楠,硕士研究生,研究方向为营养与疾病,电子信箱:wangnan0818@sina.com。, 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