Article(id=1242134951538271033, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242134933657952982, articleNumber=null, orderNo=14, doi=10.3981/j.issn.1000-7857.2016.11.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1463414400000, receivedDateStr=2016-05-17, revisedDate=1464451200000, revisedDateStr=2016-05-29, acceptedDate=null, acceptedDateStr=null, onlineDate=1467187599447, onlineDateStr=2016-06-29, pubDate=1465747200000, pubDateStr=2016-06-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1467187599447, onlineIssueDateStr=2016-06-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077650194, creator=sys-migrate, updateTime=1774077650194, updator=sys-migrate, issue=Issue{id=1242134933657952982, tenantId=1146029695717560320, journalId=1146031591421210625, year='2016', volume='34', issue='11', pageStart='1', pageEnd='100', issueExtLink='null', onlineDate='null', pubDate='1465747200000', pubDateStr='2016-06-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077645932, creator='sys-migrate', updateTime=1774077645932, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=53, endPage=59, ext={EN=ArticleExt(id=1242134954658837340, articleId=1242134951538271033, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Technical composition and developments of patents regarding Liraglutide, columnId=1242133161577095994, journalTitle=Science & Technology Review, columnName=Special Issues, runingTitle=null, highlight=null, articleAbstract=Liraglutide is a GLP-1 analogue produced from yeasts via the gene recombination, mainly used in treatment of type Ⅱ diabetes. The patents related with liraglutide have been increasing since 1999 with diverse technical solutions, which could be categorized into the core patents, the DDS patents, the combination patents and the second medicinal use patents. The core patents are to gain primary interests, the DDS patents create shortcuts to an alreadypatented medicine, the combination patents prevent possible infringements involving liraglutde, and the second medicinal use patents can lead to a re-capture of the market., authors=HUANG Jia¹, WANG Jun², authorsList=HUANG Jia, WANG Jun, authorCompany=1. Pharmacy and Biotech Examination Department, Patent Office, State Intellectual Property Office of the PRC, Beijing 100088, China;
2. Chemistry Examination Department, Patent Office, State Intellectual Property Office of the PRC, Beijing 100088, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=LuLO6RV4sAAwTiMZtZf7aA==, pdfFileSize=2358080, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242134953681560382, articleId=1242134951538271033, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=利拉鲁肽专利技术构成及发展, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=利拉鲁肽(Liraglutide)是一种通过基因重组技术并利用酵母生产的GLP-1类似物,主要用于治疗人Ⅱ型糖尿病。围绕利拉鲁肽展开的专利申请自1999年以来连年增多,技术方案的类型也多种多样,主要分为核心专利、DDS专利、联用专利和第二药用专利。核心专利的特点在于先发制人,以原研药专利为中心开展早期布局; DDS专利常用于创造与"新药"的技术交集,利于企业立足自身优势,专注自身发展方向;联用专利以防御为主,在技术交叠区域布局,避免对原研企业的侵权;第二药用专利的特点是在对手已有布局的情况下开发新的技术方向,有利于企业重新占领市场。, authors=黄嘉¹, 王俊², authorsList=黄嘉, 王俊, authorCompany=1. 国家知识产权局专利局医药生物发明审查部, 北京 100088;
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