Article(id=1242133899472613648, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242133873476317372, articleNumber=null, orderNo=19, doi=10.3981/j.issn.1000-7857.2015.18.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1426003200000, receivedDateStr=2015-03-11, revisedDate=1435420800000, revisedDateStr=2015-06-28, acceptedDate=null, acceptedDateStr=null, onlineDate=1444992364350, onlineDateStr=2015-10-16, pubDate=1443369600000, pubDateStr=2015-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1444992364350, onlineIssueDateStr=2015-10-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077399361, creator=sys-migrate, updateTime=1774077399361, updator=sys-migrate, issue=Issue{id=1242133873476317372, tenantId=1146029695717560320, journalId=1146031591421210625, year='2015', volume='33', issue='18', pageStart='1', pageEnd='112', issueExtLink='null', onlineDate='null', pubDate='1443369600000', pubDateStr='2015-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077393164, creator='sys-migrate', updateTime=1774077393164, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=84, endPage=90, ext={EN=ArticleExt(id=1242133902651896090, articleId=1242133899472613648, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Immune regulatory function of T cell-inhibitory receptors, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=T lymphocytes play a fundamental role in cellular immune and immune regulation in immune system. However, the overactivation of T cells may induce many diseases including asthma, systemic lupus-erythematosus. It is crucial to control the T cell over-activation in the immunotherapy field. The inhibitory receptors of T cells can regulate proliferation and function of T cells by contacting with their ligands. Latest studies have indicated that T cell inhibitory receptors targeting therapy can attenuate the symptoms of diseases and graft rejection. Intensive study on the regulation of T cells would provide effective strategies for preventing and treating immune diseases., authors=WANG Shuaiwei^1,2, LUO Xuerui², LI Yangyang², LIN Fang², LI Dan², YUAN Xiaojun¹, LI Bin², authorsList=WANG Shuaiwei, LUO Xuerui, LI Yangyang, LIN Fang, LI Dan, YUAN Xiaojun, LI Bin, authorCompany=1. Shanghai Key Laboratory of Bio-energy Crops, College of Life Science, Shanghai University, Shanghai 200444, China;
2. Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=gApcb8kgYNoAHAMxMrR0QQ==, pdfFileSize=1761102, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242133901544599829, articleId=1242133899472613648, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=T细胞抑制性受体及其免疫调节作用, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=T 淋巴细胞在免疫系统中发挥细胞免疫、免疫调节等功能。然而, T 细胞的过度激活会导致疾病(如哮喘、系统性红斑狼疮等)的发生, 抑制T 细胞的过度激活是免疫治疗的重要研究方向。T 细胞抑制性受体可通过与其配体结合调控T 细胞增殖或功能发挥, 并在过敏性疾病、移植排斥等治疗中作为治疗靶点。因此, 进一步解析T 细胞抑制性受体的三维结构、配体-受体复合物组分及其下信游号通路将有助于免疫治疗的发展。本综述总结了GITR、CTLA-4、BTLA、PD-1、LAIR-1、TIM-3、TIGIT 等T 细胞抑制性受体的生理生化特性、与其配体结合后对T 细胞免疫功能的调节以及抗体药物的研究进展。, authors=王帅威^1,2, 罗雪瑞², 李扬扬², 林芳², 李丹², 袁晓君¹, 李斌², authorsList=王帅威, 罗雪瑞, 李扬扬, 林芳, 李丹, 袁晓君, 李斌, authorCompany=1. 上海大学生命科学学院;上海市能源作物育种及应用重点实验室, 上海 200444;
2. 中国科学院上海巴斯德研究所, 分子病毒与免疫学重点实验室, 上海 200031, correspAuthors=null, authorNote=王帅威,硕士研究生,研究方向为分子免疫,电子信箱:swwang@ips.ac.cnv, correspAuthorsNote=李斌,教授,研究方向为分子免疫,电子信箱:binli@sibs.ac.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=gwJq6r6JqYyugMS8Ib6zJA==, pdfFileSize=1761102, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点基础研究计划(973计划)项目(2014CB541803,2014CB541903);国家自然科学基金项目(31200647,81330072,31370863,31170825,81271835,31200646,81302532,31300711);上海市学术委员会基础研究重大重点项目(14JC1406100);国家科技重大专项(2012ZX10002007-003))}, authors=null, keywords=[Keyword(id=1242133901217444114, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242133899472613648, language=CN, orderNo=1, keyword=T 细胞), Keyword(id=1242133901297135891, 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