Article(id=1242132651855913398, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242132635556848011, articleNumber=null, orderNo=11, doi=10.3981/j.issn.1000-7857.2014.30.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1407859200000, receivedDateStr=2014-08-13, revisedDate=1411056000000, revisedDateStr=2014-09-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1415956001657, onlineDateStr=2014-11-14, pubDate=1414425600000, pubDateStr=2014-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1415956001657, onlineIssueDateStr=2014-11-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077101907, creator=sys-migrate, updateTime=1774077101907, updator=sys-migrate, issue=Issue{id=1242132635556848011, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='30', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1414425600000', pubDateStr='2014-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077098022, creator='sys-migrate', updateTime=1774077098022, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=55, endPage=58, ext={EN=ArticleExt(id=1242132657350455954, articleId=1242132651855913398, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Treatment of Gastric Cancer with DF Regimen Combined with Hyperthermic Intraperitoneal Perfusion Chemotheraphy with Cisplatin, columnId=null, journalTitle=Science & Technology Review, columnName=null, runingTitle=null, highlight=null, articleAbstract=This study aims to observe and compare the efficacy and side effect of weekly docetaxel combined with 5-fluorouracil and cisplatin intravenous treatment and weekly docetaxel plus 5-fluorouracil intravenous combined with intraperitoneal perfusion (CHPP) with cisplatin treatment. Ninety patients with advanced gastric cancer were randomized into intravenous chemotherapy group (45 patients) who received docetaxel 36 mg/m2 , iv, 1wk×3wk, CF 200 mg/m2 , iv, d1-5, 5-Fu 500 mg/m2 , iv, d1-5, DDP 25 mg/m2 , iv, d1-3, repeated every four weeks for two cycles and intravenous chemotherapy plus CHPP group (45 patients) who received docetaxel 36 mg/m2 , iv, 1wk× 3wk, CF 200 mg/m2 , iv, d1- 5, 5- FU 500 mg/m2 , iv, d1- 5, DDP 75 mg/m2 , CHPP, d1, and abdomen hyperthermia treatment with radiofrequency. The results show that all patients were assessable for response in intravenous chemotherapy group and CHPP group. The overall response rate of intravenous chemotherapy group was 44.4%. The response rate of CHPP group was 66.7%, including one CR. There was statistical difference between two groups (P =0.038). The clinical beneficial response (CBR) in intravenous chemotherapy group and CHPP group were 64.4% and 82.2%, respectively. There was apparent statistical difference (P =0.0458). The major toxicities were myelosuppression, nausea/vomiting and neurotoxicity. There was no significant difference in side effect between the two groups. Docetaxel administered by weekly infusion plus 5-fluorouracil combined with hyperthermic intraperitoneal perfusion chemotherapy with cisplatin in the treatment of advanced gastric cancer is more effective than intravenous treatment. The side effect of two groups was similar. CHPP therapy was well tolerated., authors=WU Zhibing1,2 , WU Kan1 , LI Xiadong1 , JING Saisai1 , ZHENG Zhishuang2 , TANG Rongjun2 , LAI Jianjun2 , WANG Jiahao2 , authorsList=WU Zhibing, WU Kan, LI Xiadong, JING Saisai, ZHENG Zhishuang, TANG Rongjun, LAI Jianjun, WANG Jiahao, authorCompany=1. Department of Oncology, Hangzhou First People's Hospital, Hangzhou 310006, China;P =0.038);临床受益反应(CBR)评估,静脉化疗组有效率为64.4%(29/45),热灌注化疗组为82.2%(37/45),差异有统计学意义(P =0.0458);两组副反应主要为骨髓抑制,胃肠道反应,神经毒性等,无统计学差异.多西他赛周方案、5-氟尿嘧啶联合顺铂腹腔热灌注化疗方案治疗晚期胃癌近期疗效优于单存静脉化疗,两组副反应相似,耐受性良好., authors=吴稚冰1,2 , 吴侃1 , 李夏东1 , 景赛赛1 , 郑智爽2 , 唐荣军2 , 赖建军2 , 王佳浩2 , authorsList=吴稚冰, 吴侃, 李夏东, 景赛赛, 郑智爽, 唐荣军, 赖建军, 王佳浩, authorCompany=1. 杭州市第一人民医院放疗科, 杭州310006;
科技导报
|专题论文
2014
, 32
(30) :
55
-58
DF方案联合顺铂腹腔热灌注化疗治疗晚期胃癌的临床研究
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吴稚冰1,2 , 吴侃1 , 李夏东1 , 景赛赛1 , 郑智爽2 , 唐荣军2 , 赖建军2 , 王佳浩2
作者信息
1. 杭州市第一人民医院放疗科, 杭州310006;
作者简介:
吴稚冰,研究方向为恶性肿瘤的放疗、化疗、热疗、磁疗等非手术综合治疗,电子信箱:wu_zhibing@163.com
Treatment of Gastric Cancer with DF Regimen Combined with Hyperthermic Intraperitoneal Perfusion Chemotheraphy with Cisplatin
WU Zhibing1,2 , WU Kan1 , LI Xiadong1 , JING Saisai1 , ZHENG Zhishuang2 , TANG Rongjun2 , LAI Jianjun2 , WANG Jiahao2
Affiliations
1. Department of Oncology, Hangzhou First People's Hospital, Hangzhou 310006, China;
出版时间: 2014-10-28
doi: 10.3981/j.issn.1000-7857.2014.30.009
文章导航
为观察和比较多西他赛周方案给药联合5-氟尿嘧啶(5-FU)和顺铂(DDP)静脉化疗与多西他赛(DOC)、5-氟尿嘧啶静脉给药联合顺铂腹腔热灌注,治疗晚期胃癌患者的初步疗效和副反应,将90 例晚期胃癌患者,随机分入多西他赛、5-氟尿嘧啶和顺铂静脉化疗组或多西他赛、5 氟尿嘧啶静脉化疗联合顺铂腹腔热灌注化疗组,静脉化疗组45 例,热灌注化疗组45 例.研究表明,静脉化疗组有效率为44.4%(20/45),热灌注化疗组为66.7%(30/45),其中完全缓解(CR)1 例,有统计学差异(P =0.038);临床受益反应(CBR)评估,静脉化疗组有效率为64.4%(29/45),热灌注化疗组为82.2%(37/45),差异有统计学意义(P =0.0458);两组副反应主要为骨髓抑制,胃肠道反应,神经毒性等,无统计学差异.多西他赛周方案、5-氟尿嘧啶联合顺铂腹腔热灌注化疗方案治疗晚期胃癌近期疗效优于单存静脉化疗,两组副反应相似,耐受性良好.
晚期胃癌
/
多西他赛
/
5 氟尿嘧啶
/
顺铂
/
腹腔温热灌注化疗
This study aims to observe and compare the efficacy and side effect of weekly docetaxel combined with 5-fluorouracil and cisplatin intravenous treatment and weekly docetaxel plus 5-fluorouracil intravenous combined with intraperitoneal perfusion (CHPP) with cisplatin treatment. Ninety patients with advanced gastric cancer were randomized into intravenous chemotherapy group (45 patients) who received docetaxel 36 mg/m2 , iv, 1wk×3wk, CF 200 mg/m2 , iv, d1-5, 5-Fu 500 mg/m2 , iv, d1-5, DDP 25 mg/m2 , iv, d1-3, repeated every four weeks for two cycles and intravenous chemotherapy plus CHPP group (45 patients) who received docetaxel 36 mg/m2 , iv, 1wk× 3wk, CF 200 mg/m2 , iv, d1- 5, 5- FU 500 mg/m2 , iv, d1- 5, DDP 75 mg/m2 , CHPP, d1, and abdomen hyperthermia treatment with radiofrequency. The results show that all patients were assessable for response in intravenous chemotherapy group and CHPP group. The overall response rate of intravenous chemotherapy group was 44.4%. The response rate of CHPP group was 66.7%, including one CR. There was statistical difference between two groups (P =0.038). The clinical beneficial response (CBR) in intravenous chemotherapy group and CHPP group were 64.4% and 82.2%, respectively. There was apparent statistical difference (P =0.0458). The major toxicities were myelosuppression, nausea/vomiting and neurotoxicity. There was no significant difference in side effect between the two groups. Docetaxel administered by weekly infusion plus 5-fluorouracil combined with hyperthermic intraperitoneal perfusion chemotherapy with cisplatin in the treatment of advanced gastric cancer is more effective than intravenous treatment. The side effect of two groups was similar. CHPP therapy was well tolerated.
advanced gastric carcinoma
/
docetaxel
/
5-fluorouracil
/
cisplatin
/
hyperthermic intraperitoneal perfusion chemotherapy
吴稚冰, 吴侃, 李夏东, 景赛赛, 郑智爽, 唐荣军, 赖建军, 王佳浩.
DF方案联合顺铂腹腔热灌注化疗治疗晚期胃癌的临床研究.
科技导报,
2014
, 32
(30)
: 55
-58
.
DOI: 10.3981/j.issn.1000-7857.2014.30.009
WU Zhibing, WU Kan, LI Xiadong, JING Saisai, ZHENG Zhishuang, TANG Rongjun, LAI Jianjun, WANG Jiahao.
Treatment of Gastric Cancer with DF Regimen Combined with Hyperthermic Intraperitoneal Perfusion Chemotheraphy with Cisplatin[J].
Science & Technology Review ,
2014
, 32
(30)
: 55
-58
.
DOI: 10.3981/j.issn.1000-7857.2014.30.009
2014年第32卷第30期
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文章信息
doi: 10.3981/j.issn.1000-7857.2014.30.009
接收时间：2014-08-13
首发时间：2014-11-14
出版时间：2014-10-28
收稿日期：2014-08-13
修回日期：2014-09-19
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2014.30.009
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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