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Since 2011, the tyrosine kinase inhibitor drugs such as BRAF inhibitors (Vemurafenib, Dabrafenib) and MEK inhibitor (Trametinib) have brought a hope. Whereas new immunological therapy drugs, including anti-CTLA-4 antibody (Ipilimumab) and anti-PD-1/PD-L1 antibody, have brought a brain storm to the melanoma therapy. The modes of treatment of melanoma are gradually getting rid of the traditional treatment strategy and entering a new historical stage. In the foreseeable future, the research of some new targets, various small molecular targeted drugs, immune targeting therapy of drugs, as well as combination of small molecule targeted drugs and immune targeting drugs will be the mainstream treatment of melanoma. A new era of melanoma therapy is coming. 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科技导报
| 专题论文 2014, 32(26): 15-21
黑色素瘤治疗研究进展
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郭军
作者信息
北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科; 恶性肿瘤发病机制及转移研究教育部重点实验室, 北京 100142
Research Progress in the Treatment of Melanoma
Affiliations
出版时间: 2014-09-18
doi: 10.3981/j.issn.1000-7857.2014.26.001
文章导航
黑色素瘤是一种曾经让医生束手无策的恶性肿瘤，既往治疗手段有限，放疗、化疗及传统免疫治疗疗效不佳，患者预后极差。2011 年以来，小分子靶向药物（包括BRAF 抑制剂Vemurafenib、Dabrafenib，MEK 抑制剂Trametinib 等药物）相继面世，预示着黑色素瘤内科治疗进入一个新的研究阶段。而免疫靶向治疗（如抗CTLA-4 抗体，抗PD-1、PD-L1 抗体）在多项临床试验中的成功，更是缔造了肿瘤治疗的新理念。黑色素瘤治疗逐渐摆脱传统抗肿瘤治疗的模式，进入一个崭新的历史阶段，在可预见的将来，新治疗靶点的研发、多种小分子靶向药物、多种免疫靶向药物的联合治疗，以及小分子靶向药物和免疫靶向药物的联合治疗等模式将会是黑色素瘤治疗的主流。本文主要从小分子靶向药物治疗、免疫靶向治疗、化疗3 个方面综述黑色素瘤治疗的研究进展。
Melanoma is an aggressive malignant tumor with poor prognosis by traditional therapies. Since 2011, the tyrosine kinase inhibitor drugs such as BRAF inhibitors (Vemurafenib, Dabrafenib) and MEK inhibitor (Trametinib) have brought a hope. Whereas new immunological therapy drugs, including anti-CTLA-4 antibody (Ipilimumab) and anti-PD-1/PD-L1 antibody, have brought a brain storm to the melanoma therapy. The modes of treatment of melanoma are gradually getting rid of the traditional treatment strategy and entering a new historical stage. In the foreseeable future, the research of some new targets, various small molecular targeted drugs, immune targeting therapy of drugs, as well as combination of small molecule targeted drugs and immune targeting drugs will be the mainstream treatment of melanoma. A new era of melanoma therapy is coming. This paper briefly summarizes the advances of molecule-targeted chemotherapy, immunological therapy and chemotherapy.
melanoma
/
target drugs
/
immunotherapy
郭军.
黑色素瘤治疗研究进展.
科技导报,
2014
, 32
(26)
: 15
-21
.
DOI: 10.3981/j.issn.1000-7857.2014.26.001
GUO Jun.
Research Progress in the Treatment of Melanoma[J].
Science & Technology Review ,
2014
, 32
(26)
: 15
-21
.
DOI: 10.3981/j.issn.1000-7857.2014.26.001
2014年第32卷第26期
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文章信息
doi: 10.3981/j.issn.1000-7857.2014.26.001
接收时间：2014-08-12
首发时间：2014-09-26
出版时间：2014-09-18
收稿日期：2014-08-12
修回日期：2014-08-15
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2014.26.001
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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