Article(id=1242132494972166177, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242132490027081752, articleNumber=null, orderNo=3, doi=10.3981/j.issn.1000-7857.2014.26.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1407772800000, receivedDateStr=2014-08-12, revisedDate=1408032000000, revisedDateStr=2014-08-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1411715098360, onlineDateStr=2014-09-26, pubDate=1410969600000, pubDateStr=2014-09-18, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1411715098360, onlineIssueDateStr=2014-09-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077064503, creator=sys-migrate, updateTime=1774077064503, updator=sys-migrate, issue=Issue{id=1242132490027081752, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='26', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1410969600000', pubDateStr='2014-09-18', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077063325, creator='sys-migrate', updateTime=1774077063325, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=15, endPage=21, ext={EN=ArticleExt(id=1242132497941737748, articleId=1242132494972166177, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Research Progress in the Treatment of Melanoma, columnId=1242116903087440448, journalTitle=Science & Technology Review, columnName=Spescial Issues, runingTitle=null, highlight=null, articleAbstract=Melanoma is an aggressive malignant tumor with poor prognosis by traditional therapies. Since 2011, the tyrosine kinase inhibitor drugs such as BRAF inhibitors (Vemurafenib, Dabrafenib) and MEK inhibitor (Trametinib) have brought a hope. Whereas new immunological therapy drugs, including anti-CTLA-4 antibody (Ipilimumab) and anti-PD-1/PD-L1 antibody, have brought a brain storm to the melanoma therapy. The modes of treatment of melanoma are gradually getting rid of the traditional treatment strategy and entering a new historical stage. In the foreseeable future, the research of some new targets, various small molecular targeted drugs, immune targeting therapy of drugs, as well as combination of small molecule targeted drugs and immune targeting drugs will be the mainstream treatment of melanoma. A new era of melanoma therapy is coming. This paper briefly summarizes the advances of molecule-targeted chemotherapy, immunological therapy and chemotherapy., authors=GUO Jun, authorsList=GUO Jun, authorCompany=Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education; Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China, correspAuthors=null, authorNote=null, correspAuthorsNote=10.3981/j.issn.1000-7857.2014.26.001, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=7C2/O4s90YC4vxR08FiwQg==, pdfFileSize=564721, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242132497086099727, articleId=1242132494972166177, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=黑色素瘤治疗研究进展, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=黑色素瘤是一种曾经让医生束手无策的恶性肿瘤，既往治疗手段有限，放疗、化疗及传统免疫治疗疗效不佳，患者预后极差。2011 年以来，小分子靶向药物（包括BRAF 抑制剂Vemurafenib、Dabrafenib，MEK 抑制剂Trametinib 等药物）相继面世，预示着黑色素瘤内科治疗进入一个新的研究阶段。而免疫靶向治疗（如抗CTLA-4 抗体，抗PD-1、PD-L1 抗体）在多项临床试验中的成功，更是缔造了肿瘤治疗的新理念。黑色素瘤治疗逐渐摆脱传统抗肿瘤治疗的模式，进入一个崭新的历史阶段，在可预见的将来，新治疗靶点的研发、多种小分子靶向药物、多种免疫靶向药物的联合治疗，以及小分子靶向药物和免疫靶向药物的联合治疗等模式将会是黑色素瘤治疗的主流。本文主要从小分子靶向药物治疗、免疫靶向治疗、化疗3 个方面综述黑色素瘤治疗的研究进展。, authors=郭军, authorsList=郭军, authorCompany=北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科; 恶性肿瘤发病机制及转移研究教育部重点实验室, 北京 100142, correspAuthors=null, authorNote=郭军，教授，研究方向为黑色素瘤治疗，电子信箱：guoj307@126.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=OdZTSOOKxaDoOm7ebO0vJQ==, pdfFileSize=564721, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242132496779915532, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=CN, orderNo=1, keyword=黑色素瘤), Keyword(id=1242132496859607309, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=CN, orderNo=1, keyword=靶向药物), Keyword(id=1242132496939299086, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=CN, orderNo=1, keyword=免疫治疗), Keyword(id=1242132497601999121, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=EN, orderNo=1, keyword=melanoma), Keyword(id=1242132497681690898, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=EN, orderNo=1, keyword=target drugs), Keyword(id=1242132497765576979, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132494972166177, language=EN, orderNo=1, keyword=immunotherapy)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1784015846012, createdBy=null, updatedBy=13041195026, firstLetterCn=K, firstLetterEn=K, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1283818766098219763, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1784015846037, updatedTime=1784015846037, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1283818766144357108, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1784015846048, updatedTime=1784015846048, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=K, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2014.26.001, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2014.26.001, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2014.26.001, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2014.26.001, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1410969600000, fullTextJson=null, articleText=null, reference=null)