Article(id=1242132310888358477, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242132292819301094, articleNumber=null, orderNo=13, doi=10.3981/j.issn.1000-7857.2014.21.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1396281600000, receivedDateStr=2014-04-01, revisedDate=1398787200000, revisedDateStr=2014-04-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1406885614170, onlineDateStr=2014-08-01, pubDate=1406476800000, pubDateStr=2014-07-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1406885614170, onlineIssueDateStr=2014-08-01, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077020615, creator=sys-migrate, updateTime=1774077020615, updator=sys-migrate, issue=Issue{id=1242132292819301094, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='21', pageStart='1', pageEnd='95', issueExtLink='null', onlineDate='null', pubDate='1406476800000', pubDateStr='2014-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077016306, creator='sys-migrate', updateTime=1774077016306, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=66, endPage=71, ext={EN=ArticleExt(id=1242132314617099053, articleId=1242132310888358477, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Biomarkers of Head and Neck Cancers for Metabolomics, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=The head and neck cancers are the sixth most common cause of cancer deaths. The head and neck squamous cell carcinomas (HNSCCs) are caused by the tobacco and alcohol consumption and by the infection of high-risk types of human papillomavirus. Due to the lack of biomarkers for early detection and risk assessment, more than 50% of head and neck cancer patients are often diagnosed at a late stage, and the five-year survivor rate is lower than 50%. The high-throughput analysis method based on the metabolomics technology has the potential to come up with tumor-associated biomarkers. This paper reviews the progress and challenges of the metabolomics technology in its way into the biomarker discovery of the head and neck cancer, and the future development is also discussed., authors=ZHANG Xiaotao1,2 , HOU Hongwei2 , LIU Yong1 , WANG An1 , HU Qingyuan1,2 , authorsList=ZHANG Xiaotao, HOU Hongwei, LIU Yong, WANG An, HU Qingyuan, authorCompany=1. Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;1,2 , 侯宏卫2 , 刘勇1 , 王安1 , 胡清源1,2 , authorsList=张小涛, 侯宏卫, 刘勇, 王安, 胡清源, authorCompany=1. 中国科学院合肥物质科学研究院; 中国科学院安徽光学精密机械研究所, 合肥230031;
科技导报
|综述文章
2014
, 32
(21) :
66
-71
基于代谢组学的头颈癌生物标志物研究进展
全屏
张小涛1,2 , 侯宏卫2 , 刘勇1 , 王安1 , 胡清源1,2
作者信息
1. 中国科学院合肥物质科学研究院; 中国科学院安徽光学精密机械研究所, 合肥230031;
通讯作者:
胡清源（通信作者），研究员，研究方向为吸烟与健康及生物标志物，电子信箱：huqy1965@163.com
作者简介:
张小涛，博士研究生，研究方向为吸烟与健康及生物标志物，电子信箱：zhangxiaotao9209@163.com
Biomarkers of Head and Neck Cancers for Metabolomics
ZHANG Xiaotao1,2 , HOU Hongwei2 , LIU Yong1 , WANG An1 , HU Qingyuan1,2
Affiliations
1. Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;
出版时间: 2014-07-28
doi: 10.3981/j.issn.1000-7857.2014.21.011
文章导航
头颈癌被列为世界上第六大癌症，头颈癌的主要诱因是人类乳头瘤病毒、酒精和烟草。由于缺乏早期检测和风险评估的生物标记物，超过50%的头颈癌患者往往在晚期阶段才能确诊，5年期幸存率低于50%。基于代谢组学技术的高通量分析方法具有发现肿瘤相关标志物的潜能，综述了代谢组学技术在头颈癌生物标志物发现中的应用进展和存在的问题，展望了进一步研究的主要方向。
The head and neck cancers are the sixth most common cause of cancer deaths. The head and neck squamous cell carcinomas (HNSCCs) are caused by the tobacco and alcohol consumption and by the infection of high-risk types of human papillomavirus. Due to the lack of biomarkers for early detection and risk assessment, more than 50% of head and neck cancer patients are often diagnosed at a late stage, and the five-year survivor rate is lower than 50%. The high-throughput analysis method based on the metabolomics technology has the potential to come up with tumor-associated biomarkers. This paper reviews the progress and challenges of the metabolomics technology in its way into the biomarker discovery of the head and neck cancer, and the future development is also discussed.
metabolomics
/
head and neck cancer
/
biomarkers
张小涛, 侯宏卫, 刘勇, 王安, 胡清源.
基于代谢组学的头颈癌生物标志物研究进展.
科技导报,
2014
, 32
(21)
: 66
-71
.
DOI: 10.3981/j.issn.1000-7857.2014.21.011
ZHANG Xiaotao, HOU Hongwei, LIU Yong, WANG An, HU Qingyuan.
Biomarkers of Head and Neck Cancers for Metabolomics[J].
Science & Technology Review ,
2014
, 32
(21)
: 66
-71
.
DOI: 10.3981/j.issn.1000-7857.2014.21.011
2014年第32卷第21期
PDF下载
532
96
引用本文
BibTeX
文章信息
doi: 10.3981/j.issn.1000-7857.2014.21.011
接收时间：2014-04-01
首发时间：2014-08-01
出版时间：2014-07-28
收稿日期：2014-04-01
修回日期：2014-04-30
通讯作者:
胡清源（通信作者），研究员，研究方向为吸烟与健康及生物标志物，电子信箱：huqy1965@163.com
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2014.21.011
引用本文
BibTeX
2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT
PDF下载
全屏
532
96
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
